Search Results - "Deveraux, Quinn"

Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody by Narla, Rama Krishna, Modi, Hardik, Bauer, Daniel, Abbasian, Mahan, Leisten, Jim, Piccotti, Joseph R., Kopytek, Stephan, Eckelman, Brendan P., Deveraux, Quinn, Timmer, John, Zhu, Dan, Wong, Lilly, Escoubet, Laure, Raymon, Heather K., Hariharan, Kandasamy

“…Cluster of differentiation 47 (CD47) is a transmembrane protein ubiquitously expressed on human cells but overexpressed on many different tumor cells. The…”
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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function by Gray, Nathanael S, Kwiatkowski, Nicholas, Jelluma, Nannette, Filippakopoulos, Panagis, Soundararajan, Meera, Manak, Michael S, Kwon, Mijung, Choi, Hwan Geun, Sim, Taebo, Deveraux, Quinn L, Rottmann, Sabine, Pellman, David, Shah, Jagesh V, Kops, Geert J P L, Knapp, Stefan

“…Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. As…”
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Identification of a candidate therapeutic antibody for treatment of canine B-cell lymphoma by Rue, Sarah M., Eckelman, Brendan P., Efe, Jem A., Bloink, Kristin, Deveraux, Quinn L., Lowery, David, Nasoff, Marc

“…B-cell lymphoma is one of the most frequently observed non-cutaneous neoplasms in dogs. For both human and canine BCL, the standard of care treatment typically…”
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Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening by Aza-Blanc, Pedro, Cooper, Christopher L., Wagner, Klaus, Batalov, Serge, Deveraux, Quinn L., Cooke, Michael P.

“…New opportunities in mammalian functional genomics are emerging through the combination of high throughput technology and methods that allow manipulation of…”
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X-linked IAP is a direct inhibitor of cell-death proteases by Reed, John C, Deveraux, Quinn L, Takahashi, Ryosuke, Salvesen, Guy S

“…The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in regulating programmed cell death in animals ranging from insects to…”
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Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin by WAGNER, Klaus W, SAPINOSO, Lisa M, EL-RIFAI, Wa'El, FRIERSON, Henry F, BUTZ, Nicole, MESTAN, Juergen, HOFMANN, Francesco, DEVERAUX, Quinn L, HAMPTON, Garret M

“…Gene expression profiling of anatomically diverse carcinomas and their corresponding normal tissues was used to identify genes with cancer-associated…”
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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis by Reed, John C, Matsuyama, Shigemi, Llopis, Juan, Deveraux, Quinn L, Tsien, Roger Y

“…Mitochondria trigger apoptosis by releasing caspase activators, including cytochrome c (cytC). Here we show, using a pH-sensitive green fluorescent protein…”
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Caspase-2 Can Function Upstream of Bid Cleavage in the TRAIL Apoptosis Pathway by Wagner, Klaus W, Engels, Ingo H, Deveraux, Quinn L

“…In many mammalian cell types, engagement of the TRAIL/Apo2L death receptors DR4 and DR5 alters mitochondrial physiology, thereby promoting the release of…”
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A TRAIL Receptor-Dependent Synthetic Lethal Relationship between MYC Activation and GSK3β/FBW7 Loss of Function by Sabine Rottmann, Wang, Yan, Nasoff, Marc, Deveraux, Quinn L., Quon, Kim C.

“…The MYC protooncogene is frequently deregulated in human cancers. Here, by screening a kinase-directed library of small inhibitory RNAs, we identify glycogen…”
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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases by Deveraux, Quinn L., Leo, Eugen, Stennicke, Henning R., Welsh, Kate, Salvesen, Guy S., Reed, John C.

“…Several human inhibitor of apoptosis (IAP) family proteins function by directly inhibiting specific caspases in a mechanism that does not require IAP cleavage…”
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Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway by Wang, Yan, Engels, Ingo H, Knee, Deborah A, Nasoff, Marc, Deveraux, Quinn L, Quon, Kim C

“…The genetic concept of synthetic lethality provides a framework for identifying genotype-selective anticancer agents. In this approach, changes in cellular…”
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Bax Directly Induces Release of Cytochrome c from Isolated Mitochondria by Jurgensmeier, Juliane M., Xie, Zhihua, Deveraux, Quinn, Ellerby, Lisa, Bredesen, Dale, Reed, John C.

“…Bax is a pro-apoptotic member of the Bcl-2 protein family that resides in the outer mitochondrial membrane. It is controversial whether Bax promotes cell death…”
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IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition by Sanna, M. Germana, Correia, Jean da Silva, Ducrey, Odile, Lee, Jongdae, Nomoto, Ken, Schrantz, Nicolas, Deveraux, Quinn L., Ulevitch, Richard J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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12 Key pharmacokinetic and pharmacodynamic parameters that correlate with the anti-tumor activity of a bispecific PD-L1 conditional 4–1BB agonist by Kinkead, Heather, Macedo, Chelsie, Sanabria, Angelica, Cyprus, Garrett, Pandit, Rajay, Kalabus, James, Becklund, Bryan, Sulzmaier, Florian, Timmer, John, Deveraux, Quinn, Eckelman, Brendan, Heidt, Analeah

“…Background4-1BB is a costimulatory molecule that is predominantly expressed on activated CD8+ T cells and is induced upon T cell receptor mediated activation.1…”
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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases by Deveraux, Quinn L., Roy, Natalie, Stennicke, Henning R., Van Arsdale, Todd, Zhou, Qiao, Srinivasula, Srinivasa M., Alnemri, Emad S., Salvesen, Guy S., Reed, John C.

“…Inhibitor of apoptosis (IAP) gene products play an evolutionarily conserved role in regulating programmed cell death in diverse species ranging from insects to…”
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C-Terminal-Binding Protein Corepresses Epithelial and Proapoptotic Gene Expression Programs by Grooteclaes, Madeleine, Deveraux, Quinn, Hildebrand, Jeffrey, Zhang, Qinghong, Goodman, Richard H., Frisch, Steven M.

“…The genesis of carcinoma cells often involves epithelial-to-mesenchymal transitions and the acquisition of apoptosis resistance, but it is unclear whether…”
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856 INBRX-106: a novel hexavalent anti-OX40 agonist for the treatment of solid tumors by Rowell, Emily, Kinkead, Heather, Torretti, Elisabeth, Becklund, Bryan, Sulzmaier, Florian, Crago, William, Jones, Kyle, Timmer, John, Deveraux, Quinn, Eckelman, Brendan, Heidt, Analeah

“…BackgroundOX40 is a co-stimulatory receptor enriched on immune cells in the tumor microenvironment. OX40 agonism promotes anti-tumor responses, both singly and…”
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A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases by Takahashi, R, Deveraux, Q, Tamm, I, Welsh, K, Assa-Munt, N, Salvesen, G S, Reed, J C

“…The inhibitor of apoptosis proteins (IAPs) constitute an evolutionarily conserved family of homologous proteins that suppress apoptosis induced by multiple…”
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Pro-caspase-3 Is a Major Physiologic Target of Caspase-8 by Stennicke, Henning R., Jürgensmeier, Juliane M., Shin, Hwain, Deveraux, Quinn, Wolf, Beni B., Yang, Xiaohe, Zhou, Qiao, Ellerby, H. Michael, Ellerby, Lisa M., Bredesen, Dale, Green, Douglas R., Reed, John C., Froelich, Christopher J., Salvesen, Guy S.

“…The apoptotic signal triggered by ligation of members of the death receptor family is promoted by sequential activation of caspase zymogens. We show here that…”
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Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle by Ren, Yan-Guo, Wagner, Klaus W, Knee, Deborah A, Aza-Blanc, Pedro, Nasoff, Marc, Deveraux, Quinn L

“…TRAIL (TNF-related apoptosis-inducing ligand) death receptors DR4 and DR5 facilitate the selective elimination of malignant cells through the induction of…”
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