Search Results - "Devens, B."

A Pilot Trial Targeting the ICOS–ICOS‐L Pathway in Nonhuman Primate Kidney Transplantation by Lo, D. J., Anderson, D. J., Song, M., Leopardi, F., Farris, A. B., Strobert, E., Chapin, S., Devens, B., Karrer, E., Kirk, A. D.

“…Costimulation blockade with the B7‐CD28 pathway‐specific agent belatacept is now used in clinical kidney transplantation, but its efficacy remains imperfect…”
Get full text

The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism by Cherwinski, H M, McCarley, D, Schatzman, R, Devens, B, Ransom, J T

“…Leflunomide is a novel and effective immunosuppressant that holds promise as a therapeutic agent, but the mechanism of action is unknown. Here we provide…”
Get more information

Polyamine depletion therapy in prostate cancer by Devens, B H, Weeks, R S, Burns, M R, Carlson, C L, Brawer, M K

“…The prostate gland has among the highest level of polyamines in the body and prostate carcinomas have even greater elevated polyamine levels. These ubiquitous…”
Get full text

Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid by Nelson, Peter H, Carr, Stephen F, Devens, Bruce H, Eugui, Elsie M, Franco, Fidencio, Gonzalez, Carlos, Hawley, Ronald C, Loughhead, David G, Milan, David J, Papp, Eva, Patterson, John W, Rouhafza, Sussan, Sjogren, Eric B, Smith, David B, Stephenson, Rebecca A, Talamas, Francisco X, Waltos, Ann-Marie, Weikert, Robert J, Wu, John C

“…Structure−activity relationships in the region of the phthalide ring of the inosine monophosphate dehydrogenase inhibitor mycophenolic acid have been explored…”
Get full text

Novel Lysine–Spermine Conjugate Inhibits Polyamine Transport and Inhibits Cell Growth When Given with DFMO by Weeks, Reitha S., Vanderwerf, Scott M., Carlson, C.Lance, Burns, Mark R., O'Day, Christine L., Cai, Feng, Devens, Bruce H., Webb, Heather K.

“…Polyamines are ubiquitous molecules with multiple intracellular functions. Cells tightly regulate their levels through feedback mechanisms affecting synthesis,…”
Get full text

A Pilot Trial Targeting the ICOS-ICOS-L Pathway in Nonhuman Primate Kidney Transplantation: Abstract# A78 by Lo, D., Anderson, D., Leopardi, F., Song, M., Strobert, E., Chapin, S., Devens, B., Karrer, E., Kirk, A.

Get full text

Influence of dietary restriction and aging on natural killer cell activity in mice by Weindruch, R, Devens, BH, Raff, HV, Walford, RL

“…Natural killer cells (NK) are believed to defend against tumor growth. Because rodents subjected to dietary restriction without malnutrition live longer and…”
Get full text

Involvement of two distinct regulatory T cell populations in the antigen-specific suppression of cytolytic T cell generation by Devens, BH, Koontz, AW, Kapp, JA, Pierce, CW, Webb, DR

“…Alloantigen-specific, radiation-resistant T cells generated in mixed-lymphocyte cultures inhibited the generation of allospecific CTL responses in vitro. This…”
Get full text

Production of human-human hybridomas secreting antibody to sheep erythrocytes after in vitro immunization by Strike, LE, Devens, BH, Lundak, RL

“…This report describes the formation of human hybridomas after in vitro immunization of tonsillar lymphocytes and fusion of the stimulated lymphocytes with a…”
Get full text

Antipeptide antibody specific for the N-terminal of soluble immune response suppressor neutralizes concanavalin A and IFN-induced suppressor cell activity in an in vitro cytotoxic T lymphocyte response by Devens, BH, Semenuk, G, Webb, DR

“…Soluble immune response suppressor (SIRS) is a nonspecific immunosuppressive lymphokine produced by Lyt-2+ lymphocytes after exposure to Con A, IFN-alpha, or…”
Get full text

Transduction of the IFN-gamma signal for HLA-DR expression in the promonocytic line THP-1 involves a late-acting PKC activity by Gumina, R J, Freire-Moar, J, DeYoung, L, Webb, D R, Devens, B H

“…Interferon gamma (IFN-gamma) is the most potent known lymphokine for activating macrophages and has been shown to induce expression of HLA-DR in THP-1 cells, a…”
Get more information

Effects of subchronic treatment with O,O,S-trimethyl phosphorothioate on cellular and humoral immune response systems by Rodgers, K E, Imamura, T, Devens, B H

“…The effect of a 14-day treatment with low doses of O,O,S-Trimethyl phosphorothioate (OOS-TMP), an impurity in technical malathion, on the generation of…”
Get more information

Antipeptide antibody specific for the N-terminal of soluble immune response suppressor neutralizes concavalin A and IFN-induced suppressor cell activity in an in vitro cytotoxic T lymphocyte response by DEVENS, B. H, SEMENUK, G, WEBB, D. R

“…Soluble immune response suppressor (SIRS) is a nonspecific immunosuppressive lymphokine produced by Lyt-2 super(+) lymphocytes after exposure to Con A, IFN-…”
Get full text

Putative N-terminal sequence of murine soluble immune response suppressor (SIRS): significant homology with short neurotoxin 1 by Webb, D R, Mensi, N, Freire-Moar, J, Schnaper, H W, Lewis, R V, Semenuk, G, Devens, B H, Koontz, A, Danho, W, Pan, Y C

“…Soluble immune response suppressor (SIRS) is a low-molecular-weight protein (approximately 10,000 daltons) produced by mitogen- or interferon-activated T…”
Get more information

Investigations into the mechanism of immunosuppression caused by acute treatment with O,O,S-trimethyl phosphorothioate: generation of suppressive macrophages from treated animals by Rodgers, K E, Imamura, T, Devens, B H

“…At concentrations normally found in the spleen, macrophages from animals treated with O,O,S-trimethyl phosphorothioate (OOS-TMP) for 24 hr were previously…”
Get more information

Phenotypic Identification of Specific and Nonspecific Suppressor T-Cell Populations Involved in the in Vivo Response to Alloantigen by Devens, Bruce H., Webb, David R.

“…The monoclonal antibody 984.D4.6 (ma984) has been previously shown to recognize antigen-specific suppressor T-cells in an in vitro alloantigenic…”
Get full text

Organophosphorus pesticide immunotoxicity: effects of O,O,S-trimethyl phosphorothioate on cellular and humoral immune response systems by Rodgers, K E, Imamura, T, Devens, B H

“…The time course of immunosuppression induced by acute treatment with O,O,S-trimethyl phosphorothioate (OOS-TMP), an impurity in technical formulations of…”
Get more information

Immune responses to weakly immunogenic virally induced tumors. VI. Comparison of the immune response of the hybrid to the immune responses of the parents reveals "hybrid responsiveness" effect by Devens, B, Naor, D

Get full text

A 69-kDa Membrane Protein Associated with Lipopolysaccharide (LPS)-Induced Signal Transduction in the Human Monocytic Cell Line THP-1 by Fukuse, Satoshi, Maeda, Toshiro, Webb, David R., Devens, Bruce H.

“…Lipopolysaccharide (LPS) triggers a wide range of cellular responses in mammalian cells. Several proteins, including CD14, have been reported to possess LPS…”
Get full text

Induction of murine fibrosarcomas by low dose treatment with 3-methylcholanthrene followed by promotion with 12-O-tetradecanoyl-phorbol-13-acetate by Devens, B H, Lundak, R L, Byus, C V

“…Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the…”
Get more information