Search Results - "Developmental cell"

Exosome-Mediated Metastasis: Communication from a Distance by Wortzel, Inbal, Dror, Shani, Kenific, Candia M., Lyden, David

“…Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell…”
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Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis by Lu, Wei, Kang, Yibin

“…Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-epithelial transition (MET), are fundamental processes in embryonic…”
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The Hippo Signaling Pathway in Development and Disease by Zheng, Yonggang, Pan, Duojia

“…The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases,…”
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Thriving under Stress: How Plants Balance Growth and the Stress Response by Zhang, Heng, Zhao, Yang, Zhu, Jian-Kang

“…Defense against stress and active suppression of growth are two complementary strategies by which plants respond to adverse environments. Although beneficial…”
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Lipid metabolism in cancer: New perspectives and emerging mechanisms by Broadfield, Lindsay A., Pane, Antonino Alejandro, Talebi, Ali, Swinnen, Johannes V., Fendt, Sarah-Maria

“…Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell death, and seed in secondary organs. An increased focus on cancer…”
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Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract by Smith, Joan C., Sausville, Erin L., Girish, Vishruth, Yuan, Monet Lou, Vasudevan, Anand, John, Kristen M., Sheltzer, Jason M.

“…The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of angiotensin…”
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Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export by Brown, Caitlin W., Amante, John J., Chhoy, Peter, Elaimy, Ameer L., Liu, Haibo, Zhu, Lihua Julie, Baer, Christina E., Dixon, Scott J., Mercurio, Arthur M.

“…Ferroptosis, regulated cell death characterized by the iron-dependent accumulation of lethal lipid reactive oxygen species, contributes to tissue homeostasis…”
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ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation by Miao, Guangyan, Zhao, Hongyu, Li, Yan, Ji, Mingming, Chen, Yong, Shi, Yi, Bi, Yuhai, Wang, Peihui, Zhang, Hong

“…Autophagy acts as a cellular surveillance mechanism to combat invading pathogens. Viruses have evolved various strategies to block autophagy and even subvert…”
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Distinct contributions of partial and full EMT to breast cancer malignancy by Lüönd, Fabiana, Sugiyama, Nami, Bill, Ruben, Bornes, Laura, Hager, Carolina, Tang, Fengyuan, Santacroce, Natascha, Beisel, Christian, Ivanek, Robert, Bürglin, Thomas, Tiede, Stefanie, van Rheenen, Jacco, Christofori, Gerhard

“…Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-differentiation where cancer cells transit between various stages of an…”
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The Extracellular Matrix Modulates the Metastatic Journey by Kai, FuiBoon, Drain, Allison P., Weaver, Valerie M.

“…The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth, survival, and invasion of the cancer and modifies fibroblast and immune…”
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EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration by Aiello, Nicole M., Maddipati, Ravikanth, Norgard, Robert J., Balli, David, Li, Jinyang, Yuan, Salina, Yamazoe, Taiji, Black, Taylor, Sahmoud, Amine, Furth, Emma E., Bar-Sagi, Dafna, Stanger, Ben Z.

“…Epithelial-mesenchymal transition (EMT) is strongly implicated in tumor cell invasion and metastasis. EMT is thought to be regulated primarily at the…”
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Quality control of the mitochondrion by Ng, Matthew Yoke Wui, Wai, Timothy, Simonsen, Anne

“…Mitochondria are essential organelles that execute and coordinate various metabolic processes in the cell. Mitochondrial dysfunction severely affects cell…”
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Spatiotemporal Developmental Trajectories in the Arabidopsis Root Revealed Using High-Throughput Single-Cell RNA Sequencing by Denyer, Tom, Ma, Xiaoli, Klesen, Simon, Scacchi, Emanuele, Nieselt, Kay, Timmermans, Marja C.P.

“…High-throughput single-cell RNA sequencing (scRNA-seq) is becoming a cornerstone of developmental research, providing unprecedented power in understanding…”
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Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force by Zbinden, Aurélie, Pérez-Berlanga, Manuela, De Rossi, Pierre, Polymenidou, Magdalini

“…Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins found in pathological inclusions are known to undergo liquid-liquid phase…”
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Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney by Ransick, Andrew, Lindström, Nils O., Liu, Jing, Zhu, Qin, Guo, Jin-Jin, Alvarado, Gregory F., Kim, Albert D., Black, Hannah G., Kim, Junhyong, McMahon, Andrew P.

“…Chronic kidney disease affects 10% of the population with notable differences in ethnic and sex-related susceptibility to kidney injury and disease. Kidney…”
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A Single-Cell Transcriptomic Atlas of Human Skin Aging by Zou, Zhiran, Long, Xiao, Zhao, Qian, Zheng, Yandong, Song, Moshi, Ma, Shuai, Jing, Yaobin, Wang, Si, He, Yifang, Esteban, Concepcion Rodriguez, Yu, Nanze, Huang, Jiuzuo, Chan, Piu, Chen, Ting, Izpisua Belmonte, Juan Carlos, Zhang, Weiqi, Qu, Jing, Liu, Guang-Hui

“…Skin undergoes constant self-renewal, and its functional decline is a visible consequence of aging. Understanding human skin aging requires in-depth knowledge…”
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A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq by Green, Christopher Daniel, Ma, Qianyi, Manske, Gabriel L., Shami, Adrienne Niederriter, Zheng, Xianing, Marini, Simone, Moritz, Lindsay, Sultan, Caleb, Gurczynski, Stephen J., Moore, Bethany B., Tallquist, Michelle D., Li, Jun Z., Hammoud, Saher Sue

“…Spermatogenesis requires intricate interactions between the germline and somatic cells. Within a given cross section of a seminiferous tubule, multiple…”
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Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates by Zhao, Yan G., Zhang, Hong

“…In eukaryotic cells, various membrane-bound organelles compartmentalize diverse cellular activities in a spatially and temporally controlled manner. Numerous…”
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Surviving and thriving: How plants perceive and respond to temperature stress by Ding, Yanglin, Yang, Shuhua

“…The dramatic temperature fluctuations spurred by climate change inhibit plant growth and threaten crop productivity. Unraveling how plants defend themselves…”
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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA by Demaria, Marco, Ohtani, Naoko, Youssef, Sameh A., Rodier, Francis, Toussaint, Wendy, Mitchell, James R., Laberge, Remi-Martin, Vijg, Jan, Van Steeg, Harry, Dollé, Martijn E.T., Hoeijmakers, Jan H.J., de Bruin, Alain, Hara, Eiji, Campisi, Judith

“…Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the accumulation of senescent cells is thought to drive age-related…”
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