Search Results - "Development (Cambridge)"

Making muscle: skeletal myogenesis in vivo and in vitro by Chal, Jérome, Pourquié, Olivier

“…Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative properties results in debilitating musculoskeletal disorders…”
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Wnt signalling: conquering complexity by Wiese, Katrin E, Nusse, Roel, van Amerongen, Renée

“…The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs, zebrafish and beyond, sketching the outlines of a molecular…”
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Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast by Stirparo, Giuliano G, Boroviak, Thorsten, Guo, Ge, Nichols, Jennifer, Smith, Austin, Bertone, Paul

“…Single-cell profiling techniques create opportunities to delineate cell fate progression in mammalian development. Recent studies have provided transcriptome…”
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Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes by Burger, Alexa, Lindsay, Helen, Felker, Anastasia, Hess, Christopher, Anders, Carolin, Chiavacci, Elena, Zaugg, Jonas, Weber, Lukas M, Catena, Raul, Jinek, Martin, Robinson, Mark D, Mosimann, Christian

“…CRISPR-Cas9 enables efficient sequence-specific mutagenesis for creating somatic or germline mutants of model organisms. Key constraints in vivo remain the…”
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JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates by Herrera, Salvador C, Bach, Erika A

“…The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues from extracellular cytokines into transcriptional changes in the nucleus…”
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Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids by Turner, David A, Girgin, Mehmet, Alonso-Crisostomo, Luz, Trivedi, Vikas, Baillie-Johnson, Peter, Glodowski, Cherise R, Hayward, Penelope C, Collignon, Jérôme, Gustavsen, Carsten, Serup, Palle, Steventon, Benjamin, P Lutolf, Matthias, Arias, Alfonso Martinez

“…The establishment of the anteroposterior (AP) axis is a crucial step during animal embryo development. In mammals, genetic studies have shown that this process…”
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Developmentally regulated Shh expression is robust to TAD perturbations by Williamson, Iain, Kane, Lauren, Devenney, Paul S, Flyamer, Ilya M, Anderson, Eve, Kilanowski, Fiona, Hill, Robert E, Bickmore, Wendy A, Lettice, Laura A

“…Topologically associating domains (TADs) have been proposed to both guide and constrain enhancer activity. is located within a TAD known to contain all its…”
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Understanding the extracellular forces that determine cell fate and maintenance by Kumar, Aditya, Placone, Jesse K, Engler, Adam J

“…Stem cells interpret signals from their microenvironment while simultaneously modifying the niche through secreting factors and exerting mechanical forces…”
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Wilms' tumour 1 (WT1) in development, homeostasis and disease by Hastie, Nicholas D

“…The study of genes mutated in human disease often leads to new insights into biology as well as disease mechanisms. One such gene is Wilms' tumour 1 ( ), which…”
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microRNA172 plays a crucial role in wheat spike morphogenesis and grain threshability by Debernardi, Juan Manuel, Lin, Huiqiong, Chuck, George, Faris, Justin D, Dubcovsky, Jorge

“…Wheat domestication from wild species involved mutations in the gene. The allele (wild wheats) is associated with elongated spikes and hulled grains, whereas…”
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WRKY55 transcription factor positively regulates leaf senescence and the defense response by modulating the transcription of genes implicated in the biosynthesis of reactive oxygen species and salicylic acid in Arabidopsis by Wang, Yiqiao, Cui, Xing, Yang, Bo, Xu, Shutao, Wei, Xiangyan, Zhao, Peiyu, Niu, Fangfang, Sun, Mengting, Wang, Chen, Cheng, Hao, Jiang, Yuan-Qing

“…Reactive oxygen species (ROS) and salicylic acid (SA) are two factors regulating leaf senescence and defense against pathogens. However, how a single gene…”
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PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence by Hachem, Alaa, Godwin, Jonathan, Ruas, Margarida, Lee, Hoi Chang, Ferrer Buitrago, Minerva, Ardestani, Goli, Bassett, Andrew, Fox, Sebastian, Navarrete, Felipe, de Sutter, Petra, Heindryckx, Björn, Fissore, Rafael, Parrington, John

“…ABSTRACT Activation of the egg by the sperm is the first, vital stage of embryogenesis. The sperm protein PLCζ has been proposed as the physiological agent…”
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A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells by Martyn, Iain, Brivanlou, Ali H, Siggia, Eric D

“…Long-range signaling by morphogens and their inhibitors define embryonic patterning yet quantitative data and models are rare, especially in humans. Here, we…”
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Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination by Ge, Chutian, Ye, Jian, Zhang, Haiyan, Zhang, Yi, Sun, Wei, Sang, Yapeng, Capel, Blanche, Qian, Guoying

“…The molecular mechanism underlying temperature-dependent sex determination (TSD) has been a long-standing mystery; in particular, the thermosensitive genetic…”
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Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells by Asai, Akihiro, Aihara, Eitaro, Watson, Carey, Mourya, Reena, Mizuochi, Tatsuki, Shivakumar, Pranavkumar, Phelan, Kieran, Mayhew, Christopher, Helmrath, Michael, Takebe, Takanori, Wells, James, Bezerra, Jorge A

“…A self-organizing organoid model provides a new approach to study the mechanism of human liver organogenesis. Previous animal models documented that…”
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Artificial three-dimensional niches deconstruct pancreas development in vitro by Greggio, Chiara, De Franceschi, Filippo, Figueiredo-Larsen, Manuel, Gobaa, Samy, Ranga, Adrian, Semb, Henrik, Lutolf, Matthias, Grapin-Botton, Anne

“…In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion and subsequent differentiation into insulin-producing beta cells…”
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BRC1 expression regulates bud activation potential but is not necessary or sufficient for bud growth inhibition in Arabidopsis by Seale, Madeleine, Bennett, Tom, Leyser, Ottoline

“…The degree of shoot branching in is determined by the activation of axillary buds. Bud activity is regulated by diverse environmental and developmental…”
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WOX4 and WOX14 act downstream of the PXY receptor kinase to regulate plant vascular proliferation independently of any role in vascular organisation by Etchells, J Peter, Provost, Claire M, Mishra, Laxmi, Turner, Simon R

“…In plants, the cambium and procambium are meristems from which vascular tissue is derived. In contrast to most plant cells, stem cells within these tissues are…”
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Lateral root emergence in Arabidopsis is dependent on transcription factor LBD29 regulation of auxin influx carrier LAX3 by Porco, Silvana, Larrieu, Antoine, Du, Yujuan, Gaudinier, Allison, Goh, Tatsuaki, Swarup, Kamal, Swarup, Ranjan, Kuempers, Britta, Bishopp, Anthony, Lavenus, Julien, Casimiro, Ilda, Hill, Kristine, Benkova, Eva, Fukaki, Hidehiro, Brady, Siobhan M, Scheres, Ben, Péret, Benjamin, Bennett, Malcolm J

“…Lateral root primordia (LRP) originate from pericycle stem cells located deep within parental root tissues. LRP emerge through overlying root tissues by…”
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Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing by Rognoni, Emanuel, Gomez, Celine, Pisco, Angela Oliveira, Rawlins, Emma L, Simons, Ben D, Watt, Fiona M, Driskell, Ryan R

“…New hair follicles (HFs) do not form in adult mammalian skin unless epidermal Wnt signalling is activated genetically or within large wounds. To understand the…”
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