Search Results - "Devarakonda, Krishna R."

Pharmacokinetics/pharmacodynamics of L‐ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes by Safadi, Rifaat, Rahimi, Robert S., Thabut, Dominique, Bajaj, Jasmohan S., Ram Bhamidimarri, Kalyan, Pyrsopoulos, Nikolaos, Potthoff, Amy, Bukofzer, Stan, Wang, Laurene, Jamil, Khurram, Devarakonda, Krishna R.

“…Hepatic encephalopathy (HE) is a serious neurocognitive complication of liver dysfunction, often associated with elevated plasma ammonia. Ornithine…”
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Pulmonary toxicity assessment of multiwalled carbon nanotubes in rats following intratracheal instillation by Reddy, A. Rama Narsimha, Reddy, Y. Narsimha, Krishna, Devarakonda R., Himabindu, V.

“…In this study, we have evaluated the pulmonary toxicity of intratracheally (i.t.) instilled two multi walled carbon nanotubes (MWCNT) in rats. The lungs of…”
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An improved synthesis of lysosomal activated mustard prodrug for tumor-specific activation and its cytotoxic evaluation by Adidala, Raghuramreddy, Devalapally, Harikrishna, Srivari, Chandrasekhar, Devarakonda R, Krishna, Raghuram Rao, Akkinepally

“…Cyclophosphamide, an alkylating agent widely used as anticancer agent, biotransformed in vivo to unstable phosphoramidic mustard and acrolein, where the latter…”
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Translocation and extra pulmonary toxicities of multi wall carbon nanotubes in rats by Rama Narsimha Reddy, A., Krishna, Devarakonda R., Narsimha Reddy, Y., Himabindu, V.

“…This study evaluated the ability of the multi wall carbon nanotubes (MWCNT) to induce extra pulmonary toxicities in rats following intra-tracheal (IT)…”
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In vitro binding and receptor-mediated activity of terlipressin at vasopressin receptors V1 and V2 by Jamil, Khurram, Pappas, Stephen Chris, Devarakonda, Krishna R

“…Terlipressin, a synthetic, systemic vasoconstrictor with selective activity at ­vasopressin-1 (V1) receptors, is a pro-drug for the endogenous/natural porcine…”
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Diosmin pretreatment affects bioavailability of metronidazole by RAJNARAYANA, K, REDDY, Mada S, KRISHNA, Devarakonda R

“…To screen for inhibitory effects of diosmin on cytochrome P(450)-mediated metabolism of metronidazole in healthy volunteers. Before/after non-blinded…”
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Evaluation of oxidative stress and anti-oxidant status in rat serum following exposure of carbon nanotubes by Reddy, A. Rama Narsimha, Rao, M. Venkateswar, Krishna, Devarakonda R., Himabindu, V., Reddy, Y. Narsimha

“…The aim of the present study was to evaluate the oxidative stress and anti-oxidant status in rat serum following intra-tracheal instillation of multi wall…”
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Oxidative biomarkers to assess the nanoparticle-induced oxidative stress by Anreddy, Rama Narsimha Reddy, Yellu, Narsimha Reddy, Devarakonda, Krishna R

“…Nanotechnology involves the creation and manipulation of materials at nanoscale levels to create products that exhibit novel properties. Engineered…”
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Predictive models for drugs exhibiting negative food effects based on their biopharmaceutical characteristics by Marasanapalle, Venugopal P., Crison, John R., Devarakonda, Krishna R., Li, Xiaoling, Jasti, Bhaskara R.

“…Context: A drug is defined to exhibit food effects if its pharmacokinetic parameter, area under the curve (AUC0-∞) is different when co-administered with food…”
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Does pH 6 β-galactosidase activity indicate cell senescence? by Krishna, Devarakonda R, Sperker, Bernhard, Fritz, Peter, Klotz, Ulrich

“…Apparently two forms of β-galactosidase (β-GAL) in cells or tissue sections can be detected by enzyme histochemical staining (X-GAL). Using a sensitive and…”
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Cardiovascular risk among university students from developed and developing nations by Bleske, Barry E, Erickson, Steven R, Fahoum, Sahar, Devarakonda, Krishna R, Welage, Lynda S, Koudmani, Marah, Pantham, Narayan, Edwin, Stephanie B, Devarakonda, Siddhartha, Shea, Michael J, Martha, Srinivas, Khalidi, Nabil

“…A key aspect in halting global increase in cardiovascular events is prevention and especially prevention at an early age. Unfortunately, global data regarding…”
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In vitro binding and receptor-mediated activity of terlipressin at vasopressin receptors [V.sub.1] and [V.sub.2] by Jamil, Khurram, Pappas, Stephen Chris, Devarakonda, Krishna R

“…Terlipressin, a synthetic, systemic vasoconstrictor with selective activity at vasopressin-1 ([V.sub.1]) receptors, is a pro-drug for the endogenous/natural…”
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In vitro binding and receptor-mediated activity of terlipressin at vasopressin receptors V 1 and V 2 by Jamil, Khurram, Pappas, Stephen Chris, Devarakonda, Krishna R

“…Terlipressin, a synthetic, systemic vasoconstrictor with selective activity at vasopressin-1 (V ) receptors, is a pro-drug for the endogenous/natural porcine…”
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Bioavailability of diclofenac sodium after pretreatment with diosmin in healthy volunteers by Rajnarayana, K, Venkatesham, A, Krishna, Devarakonda R

“…Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID). It undergoes extensive Phase I and Phase II metabolism and in vitro it is a specific…”
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Influence of some bioflavonoids on the transport of nitrendipine by Rajnarayana, Kandhagatla, Venkatesham, Allenki, Krishna, Devarakonda R

“…Flavonoids form a large class of phenolic substances widely distributed in nature and exhibit several biological effects. P-glycoprotein is part of a large…”
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Study on the Influence of Silymarin Pretreatment on Metabolism and Disposition of Metronidazole by Rajnarayana, Kandhagatla, Reddy, Mada Sripal, Vidyasagar, Jenugu, Krishna, Devarakonda R.

“…Summary A clinical study was undertaken in 12 healthy volunteers. At first, subjects received metronidazole (CAS 443-48-1; a substrate for cytochrome CYP3A4…”
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Extrahepatic metabolism of drugs in humans by KRISHNA, D. R, KLOTZ, U

“…Although the liver plays the major role in drug metabolism [e.g. by oxidative cytochrome P450 (CYP)-dependent phase I and conjugation or phase II reactions],…”
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Synthesis and Evaluation of Anticancer Activity of Some Imidazothiazolyl, Imidazobenzothiazolyl and Dihydroimidazothiazolyl Coumarins by Srimanth, Kagne, Rao, Vedula Rajeswar, Krishna, Devarakonda R.

“…Summary A series of 6-(2H-1-benzopyran-2-one-3-yl)imidazo[2,1-b]thiazoles (1) , 2-(2H-1-benzopyran-2-one-3-yl)imidazo[2,1-b]benzothiazoles (2) and…”
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Determination of Antioxidant Activity of Some Drugs Using High-pressure Liquid Chromatography by Karunakar, Neelam, Prabhakar, Marsanapalle C., Krishna, Devarakonda R.

“…Summary The antioxidant activities of different drugs like acetylsalicylic acid, nimesulide, dapsone, methlydopa, rifampicin and the well known antioxidants…”
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Differential expression of dipeptidyl peptidase-IV (DPP-IV) in Indian type-2 diabetic population by Venkatesham, Allenki, Srinivas, Martha, Krishna, Devarakonda R, Narayana, Pantam

“…Dipeptidyl peptidase IV (CD26; E.C. 3.4.14.5) is plasma membrane glycoprotein exopeptidase. There are no data on both phenotypic or genotypic expression and…”
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