Search Results - "Devaraj, Ezhilarasan"

Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms by Ezhilarasan, Devaraj

“…Methotrexate (MTX) is one of the most effective and widely used drugs in the management of autoimmune and dermatological diseases. Rheumatoid arthritis and…”
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Hepatic stellate cells in the injured liver: Perspectives beyond hepatic fibrosis by Ezhilarasan, Devaraj

“…Over the last two decades, our understanding of the pathological role of hepatic stellate cells (HSCs) in fibrotic liver disease has increased dramatically…”
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Critical role of estrogen in the progression of chronic liver diseases by Ezhilarasan, Devaraj

“…Estrogens regulate sexual function and also have a significant role in various pathophysiological processes. Estrogens have a non-reproductive role as the…”
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Beyond resmetirom approval for NAFLD: what has to be done? by Ezhilarasan, Devaraj

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Unraveling the pathophysiologic role of galectin‐3 in chronically injured liver by Ezhilarasan, Devaraj

“…Galectin‐3 (Gal‐3) previously referred to as S‐type lectins, is a soluble protein that specifically binds to β‐galactoside carbohydrates with high specificity…”
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Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases by Ezhilarasan, Devaraj

“…Upon liver injury, quiescent hepatic stellate cells (qHSCs), reside in the perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like…”
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An eco-friendly synthesis of Enterococcus sp.–mediated gold nanoparticle induces cytotoxicity in human colorectal cancer cells by Vairavel, Mathivadani, Devaraj, Ezhilarasan, Shanmugam, Rajeshkumar

“…Gold nanoparticles (AuNPs) have become frequently used materials in biotechnological and biomedical applications including cancer. They can be commonly…”
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Intercellular communication among liver cells in the perisinusoidal space of the injured liver: Pathophysiology and therapeutic directions by Ezhilarasan, Devaraj, Najimi, Mustapha

“…Hepatic stellate cells (HSCs) in the perisinusoidal space are surrounded by hepatocytes, liver sinusoidal endothelial cells, Kupffer cells, and other resident…”
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Syzygium cumini extract induced reactive oxygen species‐mediated apoptosis in human oral squamous carcinoma cells by Ezhilarasan, Devaraj, Apoorva, Velluru S., Ashok Vardhan, Nandhigam

“…Background Syzygium cumini (L.) Skeels (jambolan) is commonly used in Indian traditional medicine to treat a variety of diseases such as obesity, diabetes etc…”
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Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets by Ezhilarasan, Devaraj, Sokal, Etienne, Najimi, Mustapha

“…Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of extracellular matrix (ECM) in the perisinusoidal space and it is a…”
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Quercetin Inhibits the Epithelial to Mesenchymal Transition through Suppressing Akt Mediated Nuclear Translocation of β-Catenin in Lung Cancer Cell Line by Elumalai, Perumal, Ezhilarasan, Devaraj, Raghunandhakumar, Subramanian

“…Lung cancer is a first leading cause of cancer related death worldwide. Quercetin (QUE) has chemo-preventive effect against a variety of cancers. However, the…”
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The ambiguous role of sirtuins in head and neck squamous cell carcinoma by Ezhilarasan, Devaraj, Lakshmi, Thangavelu, Subha, Manoharan, Deepak Nallasamy, Veeraiyan, Raghunandhakumar, Subramanian

“…Oral cancer is one of the most leading cancer responsible for significant morbidity and mortality. The sirtuins (SIRTs) are a family of class III histone…”
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Porphyromonas gingivalis and dental stem cells crosstalk amplify inflammation and bone loss in the periodontitis niche by Ezhilarasan, Devaraj, Varghese, Sheeja S.

“…Periodontitis is the sixth most prevalent disease, and almost 3.5 billion people are affected globally by dental caries and periodontal diseases. The microbial…”
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Gracilaria foliifera (Forssk.) Børgesen ethanolic extract triggers apoptosis via activation of p53 expression in HepG2 cells by Shebi, Sasikumar, Ezhilarasan, Devaraj, Thomas, John, Chandrasekaran, Natarajan, Mukherjee, Amitava

“…Background: Hepatocellular carcinoma is one of the most common types of malignancy and causes significant morbidity and mortality worldwide. Gracilaria…”
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A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases by Ezhilarasan, Devaraj, Lakshmi, Thangavelu

“…Nonalcoholic fatty liver disease (NAFLD) defines fat accumulation in the liver, and it is commonly associated with metabolic syndromes like diabetes and…”
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Boldine treatment protects acetaminophen‐induced liver inflammation and acute hepatic necrosis in mice by Ezhilarasan, Devaraj, Raghunandhakumar, Subramanian

“…Drug‐induced liver injury (DILI) is a frequent cause responsible for acute liver failure (ALF). Acetaminophen (APAP) is a known hepatotoxin predictably causing…”
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An ecofriendly synthesized gold nanoparticles induces cytotoxicity via apoptosis in HepG2 cells by Nandhini, Joseph T., Ezhilarasan, Devaraj, Rajeshkumar, Shanmugam

“…Microbes have long been used for the synthesis of a variety of nanoparticles. Hepatocellular carcinoma (HCC) is the primary liver cancer and it is the second…”
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Oral submucosal fibrosis: An updated molecular mechanism on pathogenesis and treatment modalities by Kumar, Vadivel Jayanth, Ezhilarasan, Devaraj, Veeraiyan, Deepak Nallasamy

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Wnt/beta‐catenin signaling and its modulators in nonalcoholic fatty liver diseases by Shree Harini, Karthik, Ezhilarasan, Devaraj

“…Nonalcoholic fatty liver disease (NAFLD) is a global health concern associated with significant morbidity and mortality. NAFLD is a spectrum of diseases…”
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Syringic acid induces apoptosis in human oral squamous carcinoma cells through mitochondrial pathway by Abijeth, Bhaskhar, Ezhilarasan, Devaraj

“…Background: Syringic acid (SA) has long been used as traditional medicine and is known to have antioxidant, hepatoprotective, neuroprotective and anticancer…”
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