Search Results - "Devaraj"

Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms by Ezhilarasan, Devaraj

“…Methotrexate (MTX) is one of the most effective and widely used drugs in the management of autoimmune and dermatological diseases. Rheumatoid arthritis and…”
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Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells by Fiskus, W, Sharma, S, Shah, B, Portier, B P, Devaraj, S G T, Liu, K, Iyer, S P, Bearss, D, Bhalla, K N

“…The histone demethylase LSD1 (KDM1A) demethylates mono- and di-methylated (Me2) lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and…”
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MicroRNA interplay between hepatic stellate cell quiescence and activation by Ezhilarasan, Devaraj

“…Hepatic stellate cells (HSCs) activation play a significant role in the progression of hepatic fibrosis. During chronic liver diseases, hepatocytes are damaged…”
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Hepatic stellate cells in the injured liver: Perspectives beyond hepatic fibrosis by Ezhilarasan, Devaraj

“…Over the last two decades, our understanding of the pathological role of hepatic stellate cells (HSCs) in fibrotic liver disease has increased dramatically…”
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Critical role of estrogen in the progression of chronic liver diseases by Ezhilarasan, Devaraj

“…Estrogens regulate sexual function and also have a significant role in various pathophysiological processes. Estrogens have a non-reproductive role as the…”
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Beyond resmetirom approval for NAFLD: what has to be done? by Ezhilarasan, Devaraj

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Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective by Ezhilarasan, Devaraj

“…Oxidative stress plays an important role in the pathogenesis of various chronic liver diseases (CLD) and increasing evidence have confirmed the contributory…”
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The Future of Bioorthogonal Chemistry by Devaraj, Neal K

“…Bioorthogonal reactions have found widespread use in applications ranging from glycan engineering to in vivo imaging. Researchers have devised numerous…”
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Production of optically pure lactic acid by microbial fermentation: a review by Rawoof, Salma Aathika Abdur, Kumar, P. Senthil, Vo, Dai-Viet N., Devaraj, Kubendran, Mani, Yuvarani, Devaraj, Thiruselvi, Subramanian, Sivanesan

“…Biotransformation of organic wastes into value-added products is gaining interest owing to waste management issues, exhaustion of fossil fuels and the demand…”
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Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells by Ranganathan, Santhalakshmi, Halagowder, Devaraj, Sivasithambaram, Niranjali Devaraj

“…Quercetin is a dietary flavonoid which exerts anti-oxidant, anti-inflammatory and anti-cancer properties. In this study, we investigated the anti-proliferative…”
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Unraveling the pathophysiologic role of galectin‐3 in chronically injured liver by Ezhilarasan, Devaraj

“…Galectin‐3 (Gal‐3) previously referred to as S‐type lectins, is a soluble protein that specifically binds to β‐galactoside carbohydrates with high specificity…”
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Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models by Ezhilarasan, Devaraj

“…Thioacetamide (TAA) undergoes bioactivation in the liver by the CYP450 2E1 enzyme, resulting in the formation of TAA-S-oxide and TAA-S-dioxide. TAA-S-dioxide…”
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Quantifying the atomic neighbourhoods in complex concentrated alloys by Devaraj, Arun

“…Atom probe tomography unlocks the potential to precisely analyse the short-range ordering in a CoCrNi medium-entropy alloy…”
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Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells by Ezhilarasan, Devaraj

“…Portal hypertension is one of the most important cirrhosis-associated complications of chronic liver disease, leading to significant morbidity and mortality…”
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Deciphering the molecular pathways of saroglitazar: A dual PPAR α/γ agonist for managing metabolic NAFLD by Ezhilarasan, Devaraj

“…Saroglitazar (SARO), a dual peroxisome proliferator activated receptor (PPAR)-α/γ agonist, has been used to treat metabolic diseases such as insulin resistance…”
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Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms by Ezhilarasan, Devaraj

“…Tuberculosis (TB) remains a major global health burden. Antitubercular drugs (ATDs) such as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and…”
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Advantages and challenges in nanomedicines for chronic liver diseases: A hepatologist's perspectives by Ezhilarasan, Devaraj

“…Chronic liver diseases (CLD) are responsible for significant morbidity and mortality worldwide. CLD patients are at a high risk of developing progressive liver…”
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Relaxin in hepatic fibrosis: What is known and where to head? by Ezhilarasan, Devaraj

“…Relaxin (RLX) is a heterodimeric, polypeptide hormone that has natural anti-fibrotic activity in many organs. During the chronic liver injury, hepatic stellate…”
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Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles by Wu, Haoxing, Devaraj, Neal K

“…Conspectus Bioorthogonal chemistry has found increased application in living systems over the past decade. In particular, tetrazine bioorthogonal chemistry has…”
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Communication and quorum sensing in non-living mimics of eukaryotic cells by Niederholtmeyer, Henrike, Chaggan, Cynthia, Devaraj, Neal K.

“…Cells in tissues or biofilms communicate with one another through chemical and mechanical signals to coordinate collective behaviors. Non-living cell mimics…”
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