Search Results - "Devapregasan Moodley"

Parsing the Interferon Transcriptional Network and Its Disease Associations by Mostafavi, Sara, Yoshida, Hideyuki, Moodley, Devapregasan, LeBoité, Hugo, Rothamel, Katherine, Raj, Towfique, Ye, Chun Jimmie, Chevrier, Nicolas, Zhang, Shen-Ying, Feng, Ting, Lee, Mark, Casanova, Jean-Laurent, Clark, James D., Hegen, Martin, Telliez, Jean-Baptiste, Hacohen, Nir, De Jager, Philip L., Regev, Aviv, Mathis, Diane, Benoist, Christophe

“…Type 1 interferon (IFN) is a key mediator of organismal responses to pathogens, eliciting prototypical “interferon signature genes” that encode antiviral and…”
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Mycobacterium tuberculosis: Manipulator of Protective Immunity by Korb, Vanessa C, Chuturgoon, Anil A, Moodley, Devapregasan

“…Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of…”
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Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells by Aldridge, Daniel L, Moodley, Devapregasan, Park, Jeongho, Phan, Anthony T, Rausch, Matthew, White, Kerry F, Ren, Yue, Golin, Karin, Radaelli, Enrico, Kedl, Ross, Holland, Pamela M, Hill, Jonathan, Hunter, Christopher A

“…Mice that lack the genes for IL-27, or the IL-27 receptor, and infected with develop T cell-mediated pathology. Here, studies were performed to determine the…”
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Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease by Moodley, Devapregasan, Chuturgoon, Anil A., Khan, Sajidah, Ramkaran, Prithiksha, Phulukdaree, Alisa

“…Background: Sirtuin 1 (SIRT1), a class III histone deacetylase, has been identified as a candidate molecule affecting the epigenetic mechanisms of…”
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Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70 by Moodley, Devapregasan, Mody, Girish M, Chuturgoon, Anil A

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease, which causes synovial damage. Persistence of lymphocyte infiltrates in the rheumatoid synovium has…”
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727 Increased serum levels of EBI3 are associated with poor outcome in hepatocellular carcinoma patients and SRF388, a first-in-class IL-27 blocking antibody, inhibits the growth of murine liver tumors by Rausch, Matthew, Moodley, Devapregasan, Peluso, Marisa, Koseoglu, Secil, Hua, Jing, Tan, Gege, Masia, Ricard, Lee, Benjamin, Cousineau, Isabelle, Turcotte, Simon, Stagg, John, Palombella, Vito, Holland, Pamela, Hill, Jonathan

“…BackgroundIL-27 is a heterodimeric cytokine consisting of IL 27p28 and Epstein-Barr virus-induced gene 3 (EBI3) that binds the IL-27 receptor subunit alpha and…”
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The effects of Sutherlandia frutescens extracts in cultured renal proximal and distal tubule epithelial cells by Alisa Phulukdaree, Devapregasan Moodley, Anil Chuturgoon

“…Sutherlandia frutescens (SF), a medicinal plant indigenous to South Africa, is traditionally used to treat a diverse range of illnesses, including cancer and…”
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Apoptosis-promoting effects of Sutherlandia frutescens extracts on normal human lymphocytes in vitro by Vanessa Korb, Devapregasan Moodley, Anil Chuturgoon

“…Sutherlandia frutescens (SF), an indigenous medicinal plant to South Africa, is traditionally used to treat a diverse range of illnesses. More specifically,…”
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Association of -308 TNF-alpha promoter polymorphism with viral load and CD4 T-helper cell apoptosis in HIV-1 infected black South Africans by Gounden, Shivona, Moodley, Devapregasan, Chuturgoon, Anil, Karamchand, Leshern, Dawood, Halima

“…Objective. To determine whether the -308 TNF-α promoter polymorphism is associated with markers of HIV progression in the South African population. Methods…”
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Fumonisin B1 induces global DNA hypomethylation in HepG2 cells – An alternative mechanism of action by Chuturgoon, Anil, Phulukdaree, Alisa, Moodley, Devapregasan

“…Abstract Fumonisin B1 (FB1 ), a common mycotoxin contaminant of maize, is known to inhibit sphingolipid biosynthesis and has been implicated in cancer…”
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miR-146a Polymorphism Influences Levels of miR-146a, IRAK-1, and TRAF-6 in Young Patients with Coronary Artery Disease by Ramkaran, Prithiksha, Khan, Sajidah, Phulukdaree, Alisa, Moodley, Devapregasan, Chuturgoon, Anil A.

“…Modulation of nuclear factor KappaB (NF-κB) activation may play a role in regulating inflammatory conditions associated with coronary artery disease (CAD)…”
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Fumonisin B1 inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2 by Chuturgoon, Anil A., Phulukdaree, Alisa, Moodley, Devapregasan

“…•Fumonisin B1 (FB1) inhibits apoptosis in HepG2 liver cells.•FB1 significantly up-regulated the anti-apoptotic Birc-8/ILP-2 gene and protein expression.•FB1…”
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Expression profiling of constitutive mast cells reveals a unique identity within the immune system by Dwyer, Daniel F, Barrett, Nora A, Austen, K Frank

“…Austen and colleagues assess the transcriptional profiles of mast cells isolated from peripheral connective tissues and basophils isolated from spleen and…”
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Fumonisin B1 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b by Chuturgoon, Anil A., Phulukdaree, Alisa, Moodley, Devapregasan

“…•Fumonisin B1 significantly downregulates miR27b in HepG2 cells.•FB1, significantly upregulates CYP1B1 mRNA and protein expression in HepG2 cells.•CYP1B1 is…”
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Network pharmacology of JAK inhibitors by Moodley, Devapregasan, Yoshida, Hideyuki, Mostafavi, Sara, Asinovski, Natasha, Ortiz-Lopez, Adriana, Symanowicz, Peter, Telliez, Jean-Baptiste, Hegen, Martin, Clark, James D., Mathis, Diane, Benoist, Christophe

“…Small-molecule inhibitors of the Janus kinase family (JAKis) are clinically efficacious in multiple autoimmune diseases, albeit with increased risk of certain…”
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The Arg72 variant of the p53 functional polymorphism (rs1042522) is associated with coronary artery disease in young South Africans of Indian ancestry by Khan, Sajidah, Phulukdaree, Alisa, Ramkaran, Prithiksha, Moodley, Devapregasan, Chuturgoon, Anil A.

“…Tumor protein p53 (p53), classically referred to as a tumor suppressor gene, is involved in cell cycle regulation and may be related to atherosclerosis by…”
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Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians by Ramkaran, Prithiksha, Phulukdaree, Alisa, Khan, Sajidah, Moodley, Devapregasan, Chuturgoon, Anil A.

“…Methylenetetrahydrofolate reductase (MTHFR) reduces 5′,10′-methylenetetrahydrofolate to 5′-methyltetrahydrofolate, and is involved in remethylation of…”
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Fumonisin B1 induces global DNA hypomethylation and modulates cytochrome P450 1B1 (CYP1B1) by repressing miR-27b in HepG2 cells by Chuturgoon, Anil, Phulukdaree, Alisa, Moodley, Devapregasan

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Abstract 1802: CD39 inhibition shapes the transcriptional landscape of myeloid cells and induces proinflammatory states in the CT26 syngeneic tumor model by Moodley, Devapregasan, Carneiro, Mayra, Gas, Sonia D., Dulak, Austin, Masia, Ricard, Koseoglu, Secil, Rausch, Matthew, Panduro, Marisella, Warren, Michael C., Stagg, John, Lee, Benjamin, Holland, Pamela M., Palombella, Vito J., Lake, Andrew C.

“…Abstract Extracellular adenosine triphosphate (ATP) generated by tissue damage or immunogenic cell death initiates proinflammatory responses that are potently…”
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Atorvastatin Increases miR-124a Expression: A Mechanism of Gamt Modulation in Liver Cells by Phulukdaree, Alisa, Moodley, Devapregasan, Khan, Sajidah, Chuturgoon, Anil A.

“…ABSTRACT Atorvastatin is used to control cholesterol and lipid levels in hyperlipidaemic and hypercholesterolaemic patients. Myopathy and hepatotoxicity,…”
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