Search Results - "Devanathan, Aaron S."

Activation of PXR causes drug interactions with Paxlovid in transgenic mice by Lei, Saifei, Guo, Alice, Lu, Jie, Qi, Qian, Devanathan, Aaron S., Zhu, Junjie, Ma, Xiaochao

“…Paxlovid is a nirmatrelvir (NMV) and ritonavir (RTV) co-packaged medication used for the treatment of coronavirus disease 2019 (COVID-19). The active component…”
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Pharmacology of HIV Cure: Site of Action by Devanathan, Aaron S., Cottrell, Mackenzie L.

“…Despite significant advances in HIV treatment over the past 30 years, critical barriers to an HIV cure persist. The HIV reservoir, defined at both the cellular…”
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Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals by Neverette, Noah C, Dumond, Julie B, McMahon, Deborah K, Devanathan, Aaron S

“…The mainstay of antiretroviral therapy (ART) has been combination oral therapy. While oral ART is highly effective, nonadherence remains a chief concern…”
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Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors by Zhu, Junjie, Lei, Saifei, Lu, Jie, Hao, Yixuan, Qian, Qi, Devanathan, Aaron S., Feng, Zhiwei, Xie, Xiang-Qun, Wipf, Peter, Ma, Xiaochao

“…ATP-binding cassette subfamily G member 2 (ABCG2), an efflux transporter, is involved in multiple pathological processes. Ko143 is a potent ABCG2 inhibitor;…”
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Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for quantifying lenacapavir plasma concentrations: Application to therapeutic monitoring by West, Raymond E., Oberly, Patrick J., Riddler, Sharon A., Nolin, Thomas D., Devanathan, Aaron S.

“…•Lenacapavir is a first-in-class capsid inhibitor.•Lenacapavir was approved for the treatment of HIV in treatment-experienced patients.•Quantifying…”
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Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method to quantify antiretroviral drug concentrations in human plasma for therapeutic monitoring by West, Raymond E., Oberly, Patrick J., Riddler, Sharon A., Nolin, Thomas D., Devanathan, Aaron S.

“…Antiretroviral therapy (ART) is highly effective for the treatment of HIV-1 infection. ART previously consisted of concomitant administration of many drugs,…”
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Simultaneous quantification of five antiretrovirals in human tissues using ultra-high performance liquid chromatography-tandem mass spectrometry methods for therapeutic drug monitoring at the sites of action by West, Raymond E., Oberly, Patrick J., Saylor, Amanda J., Riddler, Sharon A., Nolin, Thomas D., Devanathan, Aaron S.

“…•Despite the success of antiretroviral therapy, HIV persists in tissues.•Adequate antiretroviral concentrations in tissues are necessary to suppress…”
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A Novel Algorithm to Improve PrEP Adherence Monitoring Using Dried Blood Spots by Devanathan, Aaron S., Dumond, Julie B., Anderson, Daijha J.C., Moody, Kristen, Poliseno, Amanda J., Schauer, Amanda P., Sykes, Craig, Gay, Cynthia L., Rosen, Elias P., Kashuba, Angela D.M., Cottrell, Mackenzie L.

“…Tenofovir diphosphate (TFVdp; an active metabolite of oral HIV pre‐exposure prophylaxis (PrEP)) is measured in dried blood spots (DBS) to estimate adherence…”
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Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates by Devanathan, Aaron S, White, Nicole R, Desyaterik, Yury, De la Cruz, Gabriela, Nekorchuk, Michael, Terry, Margaret, Busman-Sahay, Kathleen, Adamson, Lourdes, Luciw, Paul, Fedoriw, Yuri, Estes, Jacob D, Rosen, Elias P, Kashuba, Angela D M

“…Although current antiretroviral therapy (ART) has increased life expectancy, a cure for human immunodeficiency virus (HIV) remains elusive due to the…”
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Bezlotoxumab: A Novel Agent for the Prevention of Recurrent Clostridium difficile Infection by Kufel, Wesley D., Devanathan, Aaron S., Marx, Ashley H., Weber, David J., Daniels, Lindsay M.

“…During the past decade, the incidence and severity of Clostridium difficile infection (CDI) have significantly increased, leading to a rise in CDI‐associated…”
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Contemporary Drug–Drug Interactions in HIV Treatment by Devanathan, Aaron S., Anderson, Daijha J.C., Cottrell, Mackenzie L., Burgunder, Erin M., Saunders, Ashley C., Kashuba, Angela D.M.

“…Despite development of modern antiretrovirals with lower drug interaction potential than their predecessors, drug interaction challenges remain. Standard…”
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Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs by Devanathan, Aaron S, Pirone, Jason R, Akkina, Ramesh, Remling-Mulder, Leila, Luciw, Paul, Adamson, Lourdes, Garcia, J Victor, Kovarova, Martina, White, Nicole R, Schauer, Amanda P, Blake, Kimberly, Sykes, Craig, Burgunder, Erin M, Srinivas, Nithya, Rosen, Elias P, Kashuba, Angela D M

“…For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We…”
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Antiretroviral Penetration and Drug Transporter Concentrations in the Spleens of Three Preclinical Animal Models and Humans by Devanathan, Aaron S, Fallon, John K, White, Nicole R, Schauer, Amanda P, Van Horne, Brian, Blake, Kimberly, Sykes, Craig, Kovarova, Martina, Adamson, Lourdes, Remling-Mulder, Leila, Luciw, Paul, Garcia, J Victor, Akkina, Ramesh, Pirone, Jason R, Smith, Philip C, Kashuba, Angela D M

“…Adequate antiretroviral (ARV) concentrations in lymphoid tissues are critical for optimal antiretroviral therapy (ART). While the spleen contains 25% of the…”
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Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection by Gay, Cynthia L., Neo, Dayna T., Devanathan, Aaron S., Kuruc, Joann D., McGee, Kara S., Schmitz, John L., Sebastian, Joe, Shaheen, Nicholas J., Ferrari, Guido, McKellar, Mehri, Fiscus, Susan A., Hicks, Charles B., Robertson, Kevin, Kashuba, Angela D.M., Eron, Joseph J., Margolis, David M.

“…OBJECTIVES:The aim of this study was to evaluate penetration of antiretrovirals into compartments and efficacy of a dual, NRTI-sparing regimen in acute HIV…”
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How‐to guide for overcoming barriers of research and scholarship training in Pharm.D. and pharmacy residency programs by Morbitzer, Kathryn A., McLaughlin, Jacqueline E., Devanathan, Aaron S., Ozawa, Sachiko, Roth McClurg, Mary, Carpenter, Delesha M., Lee, Craig R.

“…Accrediting bodies for Doctor of Pharmacy (Pharm.D.) and postgraduate residency training programs recognize the importance of research and scholarship…”
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A Cross-Biomeasure Study to Optimize Antiretroviral Adherence Estimation by Devanathan, Aaron S., Poliseno, Amanda J., White, Nicole R., Schauer, Amanda P., Sykes, Craig, Weideman, Ann Marie K., Kilpatrick, Kayla W., Hudgens, Michael G., Gay, Cynthia L., Rosen, Elias P., Dumond, Julie B., Kashuba, Angela DM, Cottrell, Mackenzie L.

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Identifying Factors Influencing Antiretroviral Pharmacology and HIV Persistence in the Spleen by Devanathan, Aaron S

“…Little is known about ARV pharmacology—and the factors that may influence it—in the spleen, which is a lymphoid organ and contains approximately 0.3% of HIV…”
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