Search Results - "Devalla, Harsha D."

Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function by Birket, Matthew J., Ribeiro, Marcelo C., Kosmidis, Georgios, Ward, Dorien, Leitoguinho, Ana Rita, van de Pol, Vera, Dambrot, Cheryl, Devalla, Harsha D., Davis, Richard P., Mastroberardino, Pier G., Atsma, Douwe E., Passier, Robert, Mummery, Christine L.

“…Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac…”
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Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells by Birket, Matthew J, Ribeiro, Marcelo C, Verkerk, Arie O, Ward, Dorien, Leitoguinho, Ana Rita, den Hartogh, Sabine C, Orlova, Valeria V, Devalla, Harsha D, Schwach, Verena, Bellin, Milena, Passier, Robert, Mummery, Christine L

“…The development of human cardiovascular progenitor cells provides a renewable source of cardiac cell types. The inability of multipotent cardiovascular…”
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Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology by Devalla, Harsha D, Schwach, Verena, Ford, John W, Milnes, James T, El‐Haou, Said, Jackson, Claire, Gkatzis, Konstantinos, Elliott, David A, Chuva de Sousa Lopes, Susana M, Mummery, Christine L, Verkerk, Arie O, Passier, Robert

“…Drugs targeting atrial‐specific ion channels, K v 1.5 or K ir 3.1/3.4, are being developed as new therapeutic strategies for atrial fibrillation. However,…”
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Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing by Tijsen, Anke J., Cócera Ortega, Lucía, Reckman, Yolan J., Zhang, Xiaolei, van der Made, Ingeborg, Aufiero, Simona, Li, Jiuru, Kamps, Selina C., van den Bout, Anouk, Devalla, Harsha D., van Spaendonck-Zwarts, Karin Y., Engelhardt, Stefan, Gepstein, Lior, Ware, James S., Pinto, Yigal M.

“…TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte…”
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A single cell transcriptional roadmap of human pacemaker cell differentiation by Wiesinger, Alexandra, Li, Jiuru, Fokkert, Lianne, Bakker, Priscilla, Verkerk, Arie O, Christoffels, Vincent M, Boink, Gerard JJ, Devalla, Harsha D

“…Each heartbeat is triggered by the sinoatrial node (SAN), the primary pacemaker of the heart. Studies in animal models have revealed that pacemaker cells share…”
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KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas by Roost, Matthias S., van Iperen, Liesbeth, Ariyurek, Yavuz, Buermans, Henk P., Arindrarto, Wibowo, Devalla, Harsha D., Passier, Robert, Mummery, Christine L., Carlotti, Françoise, de Koning, Eelco J.P., van Zwet, Erik W., Goeman, Jelle J., Chuva de Sousa Lopes, Susana M.

“…Differentiated derivatives of human pluripotent stem cells in culture are generally phenotypically immature compared to their adult counterparts. Their…”
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A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes by Schwach, Verena, Verkerk, Arie O., Mol, Mervyn, Monshouwer-Kloots, Jantine J., Devalla, Harsha D., Orlova, Valeria V., Anastassiadis, Konstantinos, Mummery, Christine L., Davis, Richard P., Passier, Robert

“…Reporter cell lines have already proven valuable in identifying, tracking, and purifying cardiac subtypes and progenitors during differentiation of human…”
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Ultrarapid Delayed Rectifier K+ Channelopathies in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Hilderink, Sarah, Devalla, Harsha D., Bosch, Leontien, Wilders, Ronald, Verkerk, Arie O.

“…Atrial fibrillation (AF) is the most common cardiac arrhythmia. About 5–15% of AF patients have a mutation in a cardiac gene, including mutations in KCNA5 ,…”
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Molecular Analysis of Patterning of Conduction Tissues in the Developing Human Heart by Sizarov, Aleksander, Devalla, Harsha D, Anderson, Robert H, Passier, Robert, Christoffels, Vincent M, Moorman, Antoon F.M

“…BACKGROUND—Recent studies in experimental animals have revealed some molecular mechanisms underlying the differentiation of the myocardium making up the…”
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Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models by Li, Jiuru, Wiesinger, Alexandra, Fokkert, Lianne, Boukens, Bastiaan J., Verkerk, Arie O., Christoffels, Vincent M., Boink, Gerard J.J., Devalla, Harsha D.

“…Paucity of physiologically relevant cardiac models has limited the widespread application of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes…”
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Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1 by Végh, Anna M D, Verkerk, Arie O, Cócera Ortega, Lucía, Wang, Jianan, Geerts, Dirk, Klerk, Mischa, Lodder, Kirsten, Nobel, Ruby, Tijsen, Anke J, Devalla, Harsha D, Christoffels, Vincent M, Medina-Ramírez, Max, Smits, Anke M, Tan, Hanno L, Wilders, Ronald, Goumans, Marie José T H, Boink, Gerard J J

“…Electronic pacemakers still face major shortcomings that are largely intrinsic to their hardware-based design. Radical improvements can potentially be…”
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Transcriptional regulation of the cardiac conduction system by van Eif, Vincent W. W., Devalla, Harsha D., Boink, Gerard J. J., Christoffels, Vincent M.

“…The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction system (CCS), a generic term for a collection of different…”
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Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells by Wiesinger, Alexandra, Boink, Gerard J.J., Christoffels, Vincent M., Devalla, Harsha D.

“…Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract…”
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Sulfonylurea antidiabetics are associated with lower risk of out‐of‐hospital cardiac arrest: Real‐world data from a population‐based study by Eroglu, Talip E., Jia, Lixia, Blom, Marieke T., Verkerk, Arie O., Devalla, Harsha D., Boink, Gerard J.J., Souverein, Patrick C., Boer, Anthonius, Tan, Hanno L.

“…Aims Out‐of‐hospital cardiac arrest (OHCA) mostly results from ventricular tachycardia/ventricular fibrillation (VT/VF), often triggered by acute myocardial…”
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TECRL, a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT by Devalla, Harsha D, Gélinas, Roselle, Aburawi, Elhadi H, Beqqali, Abdelaziz, Goyette, Philippe, Freund, Christian, Chaix, Marie‐A, Tadros, Rafik, Jiang, Hui, Le Béchec, Antony, Monshouwer‐Kloots, Jantine J, Zwetsloot, Tom, Kosmidis, Georgios, Latour, Frédéric, Alikashani, Azadeh, Hoekstra, Maaike, Schlaepfer, Jurg, Mummery, Christine L, Stevenson, Brian, Kutalik, Zoltan, de Vries, Antoine AF, Rivard, Léna, Wilde, Arthur AM, Talajic, Mario, Verkerk, Arie O, Al‐Gazali, Lihadh, Rioux, John D, Bhuiyan, Zahurul A, Passier, Robert

“…Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole‐exome sequencing (WES) was carried out on patients from three…”
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TTN Circular RNAs Create A Backsplice Motif Essential for SRSF10 Splicing by Tijsen, Anke J., Ortega, Lucίa Cόcera, Reckman, Yolan J., Zhang, Xiaolei, van der Made, Ingeborg, Aufiero, Simona, Li, Jiuru, Kamps, Selina C., van den Bout, Anouk, Devalla, Harsha D., van Spaendonck-Zwarts, Karin Y., Engelhardt, Stefan, Gepstein, Lior, Ware, James S., Pinto, Yigal M.

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