Search Results - "Deutsch, Alexander Ja"

Targeting the Microenvironment for Treating Multiple Myeloma by Neumeister, Peter, Schulz, Eduard, Pansy, Katrin, Szmyra, Marta, Deutsch, Alexander JA

“…Multiple myeloma (MM) is a malignant, incurable disease characterized by the expansion of monoclonal terminally differentiated plasma cells in the bone marrow…”
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Immune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions by Pansy, Katrin, Uhl, Barbara, Krstic, Jelena, Szmyra, Marta, Fechter, Karoline, Santiso, Ana, Thüminger, Lea, Greinix, Hildegard, Kargl, Julia, Prochazka, Katharina, Feichtinger, Julia, Deutsch, Alexander Ja

“…The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and metastasis. Since immune cells represent a large fraction of the…”
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The CXCR4-CXCL12 -Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro by Pansy, Katrin, Feichtinger, Julia, Ehall, Barbara, Uhl, Barbara, Sedej, Miriam, Roula, David, Pursche, Beata, Wolf, Axel, Zoidl, Manuel, Steinbauer, Elisabeth, Gruber, Verena, Greinix, Hildegard T, Prochazka, Katharina T, Thallinger, Gerhard G, Heinemann, Akos, Beham-Schmid, Christine, Neumeister, Peter, Wrodnigg, Tanja M, Fechter, Karoline, Deutsch, Alexander Ja

“…In tumor cells of more than 20 different cancer types, the -axis is involved in multiple key processes including proliferation, survival, migration, invasion,…”
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Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma by Deutsch, Alexander JA, Steinbauer, Elisabeth, Hofmann, Nicole A, Strunk, Dirk, Gerlza, Tanja, Beham-Schmid, Christine, Schaider, Helmut, Neumeister, Peter

“…Chemokine receptors have a crucial role in the development and progression of lymphoid neoplasms. To determine the chemokine receptor expression profile in…”
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NR4A3 Suppresses Lymphomagenesis In Vitro and In Vivo by Induction of Similar Patterns of Pro-Apoptotic Genes like NR4A1 by Deutsch, Alexander JA, Rinner, Beate, Pichler, Martin, Fechter, Karoline, Greinix, Hildegard T., Wang, Chenguang, Beham-Schmid, Christine, Neumeister, Peter

“…The nuclear orphan receptors NR4A1 and NR4A3 have been demonstrated as cooperating tumour suppressor genes leading to rapid development of acute myeloid…”
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NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes by Deutsch, Alexander J A, Rinner, Beate, Pichler, Martin, Prochazka, Katharina, Pansy, Katrin, Bischof, Marco, Fechter, Karoline, Hatzl, Stefan, Feichtinger, Julia, Wenzl, Kerstin, Frisch, Marie-Therese, Stiegelbauer, Verena, Prokesch, Andreas, Krogsdam, Anne, Sill, Heinz, Thallinger, Gerhard G, Greinix, Hildegard T, Wang, Chenguang, Beham-Schmid, Christine, Neumeister, Peter

“…Nuclear orphan receptor NR4A1 exerts an essential tumor suppressor function in aggressive lymphomas. In this study, we investigated the hypothesized…”
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Distinct Chemokine Receptor Profile In Chronic Lymphocytic Leukaemia and Richter Transformed Diffuse Large B Cell Lymphomas Compared To Germinal Center B Cells and De Novo Diffuse Large B Cell Lymphomas by Wenzl, Kerstin, Troppan, Katharina, Deutsch, Alexander JA, Linkesch, Werner, Neumeister, Peter, Beham-Schmid, Christine

“…Chemokine receptors are G-protein-coupled cell surface receptors, which dissociate upon activation by their ligands and cause downstream signaling. Recently,…”
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Loss of NR4A1 Accelerates the Development of Aggressive Lymphomas in Myc Induced Cancerogenesis by Wenzl, Kerstin, Troppan, Katharina, Pursche, Beata, Bischof, Marco, Beham-Schmid, Christine, Greinix, Hildegard T., Neumeister, Peter, Deutsch, Alexander JA

“…Introduction and Aim: We recently described a reduced NR4A1 and NR4A3 expression chronic lymphocytic leukemia, follicular lymphoma, and diffuse large B-cell…”
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NR4A3 Possesses Tumor Suppressive Properties like NR4A1 By Regulating Pro-Apoptotic Genes in Aggressive Lymphomas and Serves As a Potential Drug Target for Lymphoma Therapy by Deutsch, Alexander JA, Rinner, Beate, Wenzl, Kerstin, Troppan, Katharina, Pursche, Beata, Greinix, Hildegard T., Beham-Schmid, Christine, Neumeister, Peter

“…Recently, we described a significant down-regulation of NR4A1 (Nur77) and NR4A3 (Nor-1)-two members of the orphan nuclear receptors acting together as critical…”
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The Chemokine Receptor Profile As Distinctive Criterion Between Normal B-Cell Subsets and As Potential Discriminative Marker to Identify the Cell of Origin in Patients with Chronic Lymphocytic Leukemia and Richter Syndrome by Troppan, Katharina, Wenzl, Kerstin, Neumeister, Peter, Beham-Schmid, Christine, Przekopowitz, Martina, Greinix, Hildegard T., Schaider, Helmut, Deutsch, Alexander JA

“…Chemokine receptors are G-protein-coupled cell surface receptors, which dissociate upon activation by their ligands and cause downstream signaling. Several…”
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Impact of the microenvironment on the pathogenesis of mucosa-associated lymphoid tissue lymphomas by Uhl, Barbara, Prochazka, Katharina T, Fechter, Karoline, Pansy, Katrin, Greinix, Hildegard T, Neumeister, Peter, Deutsch, Alexander Ja

“…Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue (MALT), also known as MALT…”
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NR4A1 Mediated Apoptosis of Aggressive Lymphoma Cells Suppresses Tumor Growth in a Xenograft Model by Deutsch, Alexander JA, Rinner, Beate, Pichler, Martin, Reitter, Sonja, Beham-Schmid, Christine, Neumeister, Peter

“…Abstract 2408 NR4A1 (Nur77) and NR4A3 (Nor-1) are two members of the orphan nuclear receptors (NRs). Their function as critical tumour suppressor genes (TSG)…”
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Chlamydia psittaci Infection in Nongastrointestinal Extranodal MALT Lymphomas and Their Precursor Lesions by AIGELSREITER, Ariane, GERLZA, Tanja, KESSLER, Harald H, NEUMEISTER, Peter, DEUTSCH, Alxxander J. A, LEITNER, Eva, BEHAM-SCHMID, Christine, BEHAM, Alfred, POPPER, Helmut, BOREL, Nicole, POSPISCHIL, Andreas, RADERER, Markus

“…Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence of…”
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Ccytosporone-B Induces NR4A1 Meditated Apoptosis In Aggressive Lymphoma Cells by Deutsch, Alexander JA, Rinner, Beate, Knausz, Heike, Linkesch, Werner, Beham-Schmid, Christine, Neumeister, Peter

“…Abstract 467 NR4A1 (also called Nur77, TR3, or NGFI-B) and NR4A3 (Nor-1 or Minor) are two of three members of the orphan nuclear hormone receptor (NR) family…”
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The Nuclear Orphan Receptors NR4A1 and NR4A3 as Putative Tumour Suppressor Genes in Aggressive Non-Hodgkin's Lymphomas by Deutsch, Alexander JA, Beham-Schmid, Christine, Linkesch, Werner, Neumeister, Peter

“…Abstract 2967 Poster Board II-943 NR4A1 (Nur77, TR3, or NGFI-B), NR4A2 (Nurr1 or RNR-1) and NR4A3 (Nor-1 or Minor) are three members of the orphan nuclear…”
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Relapsed MALT Lymphomas Are Associated with a Restricted VH3-30.3 Immunoglobulin VH Gene Repertoire and Are Targeted by Aberrant Somatic Hypermutation by Deutsch, Alexander JA, Brezinschek, Ruth I, Brezinschek, Hans-Peter, Beham-Schmid, Christine, Neumeister, Peter

“…Mucosa associated lymphoid tissue (MALT) type lymphomas are B-cell neoplasms that develop out of a reactive infiltrate; Sjoegren syndrome, Hashimoto…”
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Chlamydia psittaci in MALT lymphomas of ocular adnexals: The Austrian experience by Aigelsreiter, Ariane, Leitner, Eva, Deutsch, Alexander J.A, Kessler, Harald H, Stelzl, Evelyn, Beham-Schmid, Christine, Beham, Alfred, Krugmann, Jens, Dinges, Hans P, Linkesch, Werner, Neumeister, Peter

“…Abstract The presence of Chlamydia ( C .) psittaci , C. pneumoniae and C. trachomatis DNAs in MALT lymphomas of ocular adnexals from 13 Austrian patients were…”
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