Search Results - "Deutch, AY"

Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action by Deutch, A.Y., Öngür, D., Duman, R.S.

“…Monitoring expression of c- fos and other immediate-early genes has proven a useful method for determining potential sites of action of antipsychotic drugs…”
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Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models by Surmeier, D James, Day, Michelle, Wang, Zhongfeng, Ding, Jun, An, Xinhai, Ingham, Cali A, Shering, Andrew F, Wokosin, David, Ilijic, Ema, Sun, Zhuoxin, Sampson, Allan R, Mugnaini, Enrico, Deutch, Ariel Y, Sesack, Susan R, Arbuthnott, Gordon W

“…Parkinson disease is a common neurodegenerative disorder that leads to difficulty in effectively translating thought into action. Although it is known that…”
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Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area by Fadel, J, Deutch, A.Y

“…Dopaminergic projections to the forebrain arising from the mesencephalic ventral tegmentum modulate information processing in cortical and limbic sites. The…”
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Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs by Fitzgerald, LW, Deutch, AY, Gasic, G, Heinemann, SF, Nestler, EJ

“…Because glutamate is an important modulator of subcortical dopamine (DA) function, and abnormal glutamate/DA interactions may be involved in the…”
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Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease by ZAJA-MILATOVIC, S, MILATOVIC, D, SCHANTZ, A. M, ZHANG, J, MONTINE, K. S, SAMII, A, DEUTCH, A. Y, MONTINE, T. J

“…Dysfunction of neostriatal medium spiny neurons (MSNs) is hypothesized to underlie late-stage motor complications of Parkinson disease (PD). The authors…”
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Mechanisms of action of clozapine in the treatment of neuroleptic-resistant and neuroleptic-intolerant schizophrenia by Deutch, AY

“…The mechanisms of action which account for the effectiveness of clozapine as a pharmacotherapy for the treatment of neuroleptic non-responders and neuroleptic…”
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Effects of Antipsychotic Drugs on Neurogenesis in the Forebrain of the Adult Rat by WANG, Hui-Dong, DUNNAVANT, Floyd D, JARMAN, Tabitha, DEUTCH, Ariel Y

“…The generation of new cells in the adult mammalian brain may significantly modify pathophysiological processes in neuropsychiatric disorders. We examined the…”
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Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene by Woo, Nam-Sik, Lu, Jianming, England, Roger, McClellan, Robert, Dufour, Samuel, Mount, David B., Deutch, Ariel Y., Lovinger, David M., Delpire, Eric

“…Four genes encode electroneutral, Na+‐independent, K–Cl cotransporters. KCC2, is exclusively expressed in neurons where it is thought to drive intracellular…”
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Extracerebellar role for Cerebellin1: Modulation of dendritic spine density and synapses in striatal medium spiny neurons by Kusnoor, S.V., Parris, J., Muly, E.C., Morgan, J.I., Deutch, A.Y.

“…Cerebellin1 (Cbln1) is a secreted glycoprotein that was originally isolated from the cerebellum and subsequently found to regulate synaptic development and…”
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The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats by Scruggs, Jennifer L., Schmidt, Dennis, Deutch, Ariel Y.

“…Activation of the cerebral cortex is seen during hallucinations. The 5-HT 2A/C agonist 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) is a potent…”
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Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57 Bl6 mice by Clark, J A, Flick, R B, Pai, L-Y, Szalayova, I, Key, S, Conley, R K, Deutch, A Y, Hutson, P H, Mezey, E

“…Considerable attention has focused on regulation of central tryptophan hydroxylase (TPH) activity and protein expression. At the time of these earlier studies,…”
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Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism by Brown, Abigail M., Deutch, Ariel Y., Colbran, Roger J.

“…Nigrostriatal dopamine depletion disrupts striatal medium spiny neuron morphology in Parkinson's disease and modulates striatal synaptic plasticity in animal…”
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The effects of perinatal diazepam exposure on stress-induced activation of the mesotelencephalic dopamine system by Deutch, A Y, Gruen, R J, Roth, R H

“…The effects of perinatal diazepam exposure of rats on stress-induced metabolic activation of the mesotelencephalic dopamine (DA) system were examined…”
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Dopaminergic regulation of orexin neurons by Bubser, Michael, Fadel, Jim R., Jackson, Lela L., Meador-Woodruff, James H., Jing, Deqiang, Deutch, Ariel Y.

“…Orexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to…”
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DOI-Induced Activation of the Cortex: Dependence on 5-HT2A Heteroceptors on Thalamocortical Glutamatergic Neurons by Scruggs, Jennifer L, Patel, Sachin, Bubser, Michael, Deutch, Ariel Y

“…Administration of the hallucinogenic 5-HT(2A/2C) agonist 1-[2, 5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) induces expression of Fos protein in the cerebral…”
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Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites by Bubser, Michael, Deutch, Ariel Y.

“…The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus that responds strongly to exposure to various stressors. Many of the projection…”
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Dopaminergic regulation of extracellular gamma-aminobutyric acid levels in the prefrontal cortex of the rat by Grobin, A C, Deutch, A Y

“…Dopaminergic axons in the prefrontal cortex synapse with interneurons as well as pyramidal cells. Electrophysiological data suggest that dopamine depolarizes…”
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Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex by Willins, David L., Deutch, Ariel Y., Roth, Bryan L.

“…The distribution of 5‐HT2A receptors in rat cortex was evaluated using newly developed antibodies. Each of three antibodies tested identified an identical…”
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p90 Ribosomal S6 Kinase 2 Exerts a Tonic Brake on G Protein-Coupled Receptor Signaling by Sheffler, Douglas J., Kroeze, Wesley K., Garcia, Bonnie G., Deutch, Ariel Y., Hufeisen, Sandra J., Leahy, Patrick, Brüning, Jens C., Roth, Bryan L.

“…G protein-coupled receptors (GPCRs) are essential for normal central CNS function and represent the proximal site(s) of action for most neurotransmitters and…”
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