Search Results - "Deussing, J M"

CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery by Henckens, M J A G, Printz, Y, Shamgar, U, Dine, J, Lebow, M, Drori, Y, Kuehne, C, Kolarz, A, Eder, M, Deussing, J M, Justice, N J, Yizhar, O, Chen, A

“…The bed nucleus of the stria terminalis (BNST) is critical in mediating states of anxiety, and its dysfunction has been linked to stress-related mental…”
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Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep by Kimura, M, Müller-Preuss, P, Lu, A, Wiesner, E, Flachskamm, C, Wurst, W, Holsboer, F, Deussing, J M

“…Impaired sleep and enhanced stress hormone secretion are the hallmarks of stress-related disorders, including major depression. The central neuropeptide,…”
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Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior by Lu, A, Steiner, M A, Whittle, N, Vogl, A M, Walser, S M, Ableitner, M, Refojo, D, Ekker, M, Rubenstein, J L, Stalla, G K, Singewald, N, Holsboer, F, Wotjak, C T, Wurst, W, Deussing, J M

“…Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of affective disorders. Both, basic and clinical…”
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TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies by Erhardt, A, Czibere, L, Roeske, D, Lucae, S, Unschuld, P G, Ripke, S, Specht, M, Kohli, M A, Kloiber, S, Ising, M, Heck, A, Pfister, H, Zimmermann, P, Lieb, R, Pütz, B, Uhr, M, Weber, P, Deussing, J M, Gonik, M, Bunck, M, Keßler, M S, Frank, E, Hohoff, C, Domschke, K, Krakowitzky, P, Maier, W, Bandelow, B, Jacob, C, Deckert, J, Schreiber, S, Strohmaier, J, Nöthen, M, Cichon, S, Rietschel, M, Bettecken, T, Keck, M E, Landgraf, R, Müller-Myhsok, B, Holsboer, F, Binder, E B

“…The lifetime prevalence of panic disorder (PD) is up to 4% worldwide and there is substantial evidence that genetic factors contribute to the development of…”
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Enriched environment impacts trimethylthiazoline-induced anxiety-related behavior and immediate early gene expression: critical role of Crhr1 by Sotnikov, S. V., Chekmareva, N. Y., Schmid, B., Harbich, D., Malik, V., Bauer, S., Kuehne, C., Markt, P. O., Deussing, J. M., Schmidt, M. V., Landgraf, R.

“…It has been shown previously (Sotnikov et al., ) that mice selectively inbred for high anxiety‐related behavior (HAB) vs. low anxiety‐related behavior in the…”
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Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin‐releasing hormone signaling by Kamprath, K., Plendl, W., Marsicano, G., Deussing, J. M., Wurst, W., Lutz, B., Wotjak, C. T.

“…Recent evidence showed that the endocannabinoid system plays an important role in the behavioral adaptation of stress and fear responses. In this study, we…”
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Beware of your Cre-Ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory by Reichel, J.M., Bedenk, B.T., Gassen, N.C., Hafner, K., Bura, S.A., Almeida-Correa, S., Genewsky, A., Dedic, N., Giesert, F., Agarwal, A., Nave, K.-A., Rein, T., Czisch, M., Deussing, J.M., Wotjak, C.T.

“…ABSTRACT Expression of the lacZ‐sequence is a widely used reporter‐tool to assess the transgenic and/or transfection efficacy of a target gene in mice. Once…”
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Evidence for the role of corticotropin-releasing factor in major depressive disorder by Waters, R Parrish, Rivalan, Marion, Bangasser, D A, Deussing, J M, Ising, M, Wood, S K, Holsboer, F, Summers, Cliff H

“…Major depressive disorder (MDD) is a devastating disease affecting over 300 million people worldwide, and costing an estimated 380 billion Euros in lost…”
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Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions by Silberstein, S, Vogl, A.M, Refojo, D, Senin, S.A, Wurst, W, Holsboer, F, Deussing, J.M, Arzt, E

“…Abstract Corticotropin-releasing hormone (CRH) coordinates neuroendocrine and behavioral adaptations to stress. Acute CRH administration in vivo activates…”
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Genetic mouse models for behavioral analysis through transgenic RNAi technology by Delic, S., Streif, S., Deussing, J. M., Weber, P., Ueffing, M., Hölter, S. M., Wurst, W, Kühn, R.

“…Pharmacological inhibitors and knockout mice have developed into routine tools to analyze the role of specific genes in behavior. Both strategies have…”
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Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor by Hartmann, J, Dedic, N, Pöhlmann, M L, Häusl, A, Karst, H, Engelhardt, C, Westerholz, S, Wagner, K V, Labermaier, C, Hoeijmakers, L, Kertokarijo, M, Chen, A, Joëls, M, Deussing, J M, Schmidt, M V

“…Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain…”
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Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood by Dedic, N, Pöhlmann, M L, Richter, J S, Mehta, D, Czamara, D, Metzger, M W, Dine, J, Bedenk, B T, Hartmann, J, Wagner, K V, Jurik, A, Almli, L M, Lori, A, Moosmang, S, Hofmann, F, Wotjak, C T, Rammes, G, Eder, M, Chen, A, Ressler, K J, Wurst, W, Schmidt, M V, Binder, E B, Deussing, J M

“…Single-nucleotide polymorphisms (SNPs) in CACNA1C , the α1C subunit of the voltage-gated L-type calcium channel Ca v 1.2, rank among the most consistent and…”
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Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2 by Deussing, Jan M, Breu, Johannes, Kühne, Claudia, Kallnik, Magdalena, Bunck, Mirjam, Glasl, Lisa, Yen, Yi-Chun, Schmidt, Mathias V, Zurmühlen, Regine, Vogl, Annette M, Gailus-Durner, Valérie, Fuchs, Helmut, Hölter, Sabine M, Wotjak, Carsten T, Landgraf, Rainer, de Angelis, Martin Hrabé, Holsboer, Florian, Wurst, Wolfgang

“…Urocortin 3 (UCN3) is strongly expressed in specific nuclei of the rodent brain, at sites distinct from those expressing urocortin 1 and urocortin 2, the other…”
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Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress by Wurst, Wolfgang, Müller, Marianne B, Zimmermann, Stephan, Sillaber, Inge, Hagemeyer, Thomas P, Deussing, Jan M, Timpl, Peter, Kormann, Michael S D, Droste, Susanne K, Kühn, Ralf, Reul, Johannes M H M, Holsboer, Florian

“…Corticotropin-releasing hormone (CRH) is centrally involved in coordinating responses to a variety of stress-associated stimuli. Recent clinical data implicate…”
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Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress by Hanstein, R, Lu, A, Wurst, W, Holsboer, F, Deussing, J.M, Clement, A.B, Behl, C

“…Abstract Corticotropin releasing hormone (CRH) is the central modulator of the mammalian hypothalamic–pituitary–adrenal (HPA) axis. In addition, CRH affects…”
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Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice by Schmidt, M. V., Deussing, J. M., Oitzl, M. S., Ohl, F., Levine, S., Wurst, W., Holsboer, F., Müller, M. B., De Kloet, E. R.

“…In the adult, corticotropin‐releasing hormone (CRH) is the key mediator for the behavioural and neuroendocrine response to stress. It has also been…”
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Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system by Lu, A, Steiner, M A, Whittle, N, Vogl, A M, Walser, S M, Ableitner, M, Refojo, D, Ekker, M, Rubenstein, J L, Stalla, G K, Singewald, N, Holsboer, F, Wotjak, C T, Wurst, W, Deussing, J M

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Dissecting the genetic effect of the CRH system on anxiety and stress-related behaviour by Deussing, Jan M, Wurst, Wolfgang

“…Corticotropin-releasing hormone (CRH) plays a central role in the adaptation of the body to stress. CRH integrates the endocrine, autonomic and behavioural…”
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Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties by Hartmann, Jakob, Wagner, Klaus V, Gaali, Steffen, Kirschner, Alexander, Kozany, Christian, Rühter, Gerd, Dedic, Nina, Häusl, Alexander S, Hoeijmakers, Lianne, Westerholz, Sören, Namendorf, Christian, Gerlach, Tamara, Uhr, Manfred, Chen, Alon, Deussing, Jan M, Holsboer, Florian, Hausch, Felix, Schmidt, Mathias V

“…Anxiety-related psychiatric disorders represent one of the largest health burdens worldwide. Single nucleotide polymorphisms of the FK506 binding protein 51…”
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Enriched environment impacts trimethylthiazoline‐induced anxiety‐related behavior and immediate early gene expression: critical role of C rhr1 by Sotnikov, S. V., Chekmareva, N. Y., Schmid, B., Harbich, D., Malik, V., Bauer, S., Kuehne, C., Markt, P. O., Deussing, J. M., Schmidt, M. V., Landgraf, R.

“…Abstract It has been shown previously (Sotnikov et al ., ) that mice selectively inbred for high anxiety‐related behavior ( HAB ) vs. low anxiety‐related…”
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