Search Results - "Detrez, Jan R"

Sustained synchronized neuronal network activity in a human astrocyte co-culture system by Kuijlaars, Jacobine, Oyelami, Tutu, Diels, Annick, Rohrbacher, Jutta, Versweyveld, Sofie, Meneghello, Giulia, Tuefferd, Marianne, Verstraelen, Peter, Detrez, Jan R., Verschuuren, Marlies, De Vos, Winnok H., Meert, Theo, Peeters, Pieter J., Cik, Miroslav, Nuydens, Rony, Brône, Bert, Verheyen, An

“…Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative disorders such as autism, schizophrenia, and Alzheimer’s disease…”
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Chemogenetic silencing of neurons in the mouse anterior cingulate area modulates neuronal activity and functional connectivity by Peeters, Lore M., Hinz, Rukun, Detrez, Jan R., Missault, Stephan, De Vos, Winnok H., Verhoye, Marleen, Van der Linden, Annemie, Keliris, Georgios A.

“…The anterior cingulate area (ACC) is an integral part of the prefrontal cortex in mice and supports cognitive functions, including attentional processes,…”
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Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain by Detrez, Jan R., Maurin, Hervé, Van Kolen, Kristof, Willems, Roland, Colombelli, Julien, Lechat, Benoit, Roucourt, Bart, Van Leuven, Fred, Baatout, Sarah, Larsen, Peter, Nuydens, Rony, Timmermans, Jean-Pierre, De Vos, Winnok H.

“…We have exploited whole brain microscopy to map the progressive deposition of hyperphosphorylated tau in intact, cleared mouse brain. We found that the…”
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Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition by Shah, Disha, Praet, Jelle, Latif Hernandez, Amira, Höfling, Corinna, Anckaerts, Cynthia, Bard, Frédérique, Morawski, Markus, Detrez, Jan R, Prinsen, Els, Villa, Alessandro, De Vos, Winnok H, Maggi, Adriana, D'Hooge, Rudi, Balschun, Detlef, Rossner, Steffen, Verhoye, Marleen, Van der Linden, Annemie

“…Abstract Introduction In Alzheimer's disease (AD), pathologic amyloid-beta (Aβ) is synaptotoxic and impairs neuronal function at the microscale, influencing…”
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Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice by Detrez, Jan R., Ben-Nejma, Inès R.H., Van Kolen, Kristof, Van Dam, Debby, De Deyn, Peter Paul, Fransen, Erik, Verhoye, Marleen, Timmermans, Jean-Pierre, Nuydens, Rony, Van der Linden, Annemie, Keliris, Georgios A., De Vos, Winnok H.

“…[Display omitted] Progressive accumulation of hyperphosphorylated tau is a hallmark of various neurodegenerative disorders including Alzheimer's disease…”
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A multilevel framework to reconstruct anatomical 3D models of the hepatic vasculature in rat livers by Peeters, Geert, Debbaut, Charlotte, Laleman, Wim, Monbaliu, Diethard, Vander Elst, Ingrid, Detrez, Jan R., Vandecasteele, Tim, De Schryver, Thomas, Van Hoorebeke, Luc, Favere, Kasper, Verbeke, Jonas, Segers, Patrick, Cornillie, Pieter, De Vos, Winnok H.

“…The intricate (micro)vascular architecture of the liver has not yet been fully unravelled. Although current models are often idealized simplifications of the…”
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Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks by Verstraelen, Peter, Detrez, Jan R, Verschuuren, Marlies, Kuijlaars, Jacobine, Nuydens, Rony, Timmermans, Jean-Pierre, De Vos, Winnok H

“…Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the…”
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An improved method for large scale generation and high-throughput functional characterization of human iPSC-derived microglia by Padmakumar, Manisha, Biesmans, Steven, Valadas, Jorge S., Detrez, Jan R., Gillet, Gaëlle, Bresler, Priscillia, Clénet, Marie-Laure, Kadiu, Irena

“…Neuroscience drug discovery has faced significant challenges due to restricted access to relevant human cell models and limited translatability of existing…”
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BiDiFuse: a FIJI plugin for fusing bi-directionally recorded microscopic image volumes by Detrez, Jan R, Vanderwinden, Jean-Marie, Barbier, Michaël, Verschuuren, Marlies, Nuydens, Rony, Langlois, Xavier, Timmermans, Jean-Pierre, De Vos, Winnok H

“…Deep tissue imaging is increasingly used for non-destructive interrogation of intact organs and small model organisms. An intuitive approach to increase the…”
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Immune remodelling of stromal cell grafts in the central nervous system: therapeutic inflammation or (harmless) side‐effect? by Le Blon, Debbie, Hoornaert, Chloé, Detrez, Jan R., Bevers, Sanne, Daans, Jasmijn, Goossens, Herman, De Vos, Winnok H., Berneman, Zwi, Ponsaerts, Peter

“…Over the past two decades, several cell types with fibroblast‐like morphology, including mesenchymal stem/stromal cells, but also other adult, embryonic and…”
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Image Informatics Strategies for Deciphering Neuronal Network Connectivity by Detrez, Jan R, Verstraelen, Peter, Gebuis, Titia, Verschuuren, Marlies, Kuijlaars, Jacobine, Langlois, Xavier, Nuydens, Rony, Timmermans, Jean-Pierre, De Vos, Winnok H

“…Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and…”
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Comparison of different clearing protocols for in toto three‐dimensional microscopic imaging of the intestinal wall by Bossolani, Gleison D.P., Detrez, Jan R., Zanoni, Jacqueline Nelis, Adriaensen, Dirk, De Vos, Winnok H., Buckinx, Roeland, Timmermans, Jean‐Pierre

“…The intestinal wall has a complex 3D architecture, consisting of epithelial, immune, vascular, smooth muscle and neuronal components. Traditional 2D techniques…”
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Microscopic evaluation of synaptic connectivity and network formation in primary hippocampal neurons by Verstraelen, Peter, Timmermans, Jean‐Pierre, Detrez, Jan R, Pintelon, Isabel, Nuydens, Rony, Meert, Theo, De Vos, Winnok

“…Abstract only During brain development, orchestrated activation of genetic programs, as well as spontaneous electrical activity guide the correct wiring of…”
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Immune remodelling of stromal cell grafts in the central nervous system: therapeutic inflammation or (harmless) side-effect?: Immune remodelling of stromal cell grafts by Le Blon, Debbie, Hoornaert, Chloé, Detrez, Jan R., Bevers, Sanne, Daans, Jasmijn, Goossens, Herman, De Vos, Winnok H., Berneman, Zwi, Ponsaerts, Peter

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Corrigendum by Peeters, Geert, Debbaut, Charlotte, Laleman, Wim, Friebel, Adrian, Monbaliu, Diethard, Vander Elst, Ingrid, Jan R., Detrez, Vandecasteele, Tim, Johann, Tim, de Schryver, Thomas, van Hoorebeke, Luc, Favere, Kasper, Jonas, Verbeke, Drasdo, Dirk, Hoehme, Stefan, Segers, Patrick, Cornillie, Pieter, Winnok H. De, Vos

“…Corrigendum : A multilevel framework to reconstruct anatomical 3D models of the hepatic vasculature in rat livers.These are the new list of the authors and…”
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