Search Results - "Detmar, Michael"

Inflammation and Lymphatic Function by Schwager, Simon, Detmar, Michael

“…The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators,…”
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Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function by Ducoli, Luca, Detmar, Michael

“…The lymphatic vascular system acts as the major transportation highway of tissue fluids, and its activation or impairment is associated with a wide range of…”
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Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice by Ma, Qiaoli, Ineichen, Benjamin V., Detmar, Michael, Proulx, Steven T.

“…Cerebrospinal fluid (CSF) has been commonly accepted to drain through arachnoid projections from the subarachnoid space to the dural venous sinuses. However, a…”
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The cutaneous vascular system in chronic skin inflammation by Huggenberger, Reto, Detmar, Michael

“…The blood and lymphatic vasculature have an important role in skin homeostasis. Angiogenesis and lymphangiogenesis-the growth of new vessels from existing…”
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Sostdc1 Secreted from Cutaneous Lymphatic Vessels Acts as a Paracrine Factor for Hair Follicle Growth by Yoon, Sun-Young, Detmar, Michael

“…In our previous study, we found that lymphatic vessels stimulate hair follicle growth through paracrine effects on dermal papilla cells. However, the paracrine…”
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Lymphangiogenesis and cancer metastasis by Mumprecht, Viviane, Detmar, Michael

“…•  Anatomy and function of the lymphatic system •  Tumour‐induced lymphangiogenesis promotes metastasis •  Tumour‐induced lymph node lymphangiogenesis precedes…”
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Tumor lymphangiogenesis and melanoma metastasis by Rinderknecht, Matthias, Detmar, Michael

“…Malignant melanomas of the skin primarily metastasize to lymph nodes, and the detection of sentinel lymph node metastases serves as an important prognostic…”
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TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays by Gebäck, Tobias, Schulz, Martin Michael Peter, Koumoutsakos, Petros, Detmar, Michael

“…Cell migration plays a major role in development, physiology, and disease, and is frequently evaluated in vitro by the monolayer wound healing assay. The assay…”
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An important role of the SDF-1/CXCR4 axis in chronic skin inflammation by Zgraggen, Silvana, Huggenberger, Reto, Kerl, Katrin, Detmar, Michael

“…Inflammatory angiogenesis and vascular remodeling play key roles in the chronic inflammatory skin disease psoriasis, but little is known about the molecular…”
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Pathways Targeting Tumor Lymphangiogenesis by WISSMANN, Christoph, DETMAR, Michael

“…Tumor metastasis to sentinel lymph nodes represents the first step of tumor dissemination in most human cancers and serves as a major prognostic indicator for…”
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An important role of lymphatic vessel activation in limiting acute inflammation by Huggenberger, Reto, Siddiqui, Shoib S., Brander, Daniela, Ullmann, Stefan, Zimmermann, Kathrin, Antsiferova, Maria, Werner, Sabine, Alitalo, Kari, Detmar, Michael

“…In contrast to the established role of blood vessel remodeling in inflammation, the biologic function of the lymphatic vasculature in acute inflammation has…”
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Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation by Huggenberger, Reto, Ullmann, Stefan, Proulx, Steven T, Pytowski, Bronislaw, Alitalo, Kari, Detmar, Michael

“…The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation,…”
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Lymphatic endothelium in health and disease by Jurisic, Giorgia, Detmar, Michael

“…The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response…”
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VEGF-C–induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites by Hirakawa, Satoshi, Brown, Lawrence F., Kodama, Shohta, Paavonen, Karri, Alitalo, Kari, Detmar, Michael

“…The mechanisms by which tumors metastasize to sentinel and distant lymph nodes, and beyond, are poorly understood. We developed transgenic mice that…”
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Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer by Tacconi, Carlotta, Ungaro, Federica, Correale, Carmen, Arena, Vincenzo, Massimino, Luca, Detmar, Michael, Spinelli, Antonino, Carvello, Michele, Mazzone, Massimiliano, Oliveira, Ana I, Rubbino, Federica, Garlatti, Valentina, Spanò, Salvatore, Lugli, Enrico, Colombo, Federico S, Malesci, Alberto, Peyrin-Biroulet, Laurent, Vetrano, Stefania, Danese, Silvio, D'Alessio, Silvia

“…Colorectal cancer is a major cause of cancer-related death in Western countries and is associated with increased numbers of lymphatic vessels (LV) and…”
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Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation by Arasa, Jorge, Collado-Diaz, Victor, Kritikos, Ioannis, Medina-Sanchez, Jessica Danielly, Friess, Mona Carina, Sigmund, Elena Caroline, Schineis, Philipp, Hunter, Morgan Campbell, Tacconi, Carlotta, Paterson, Neil, Nagasawa, Takashi, Kiefer, Friedemann, Makinen, Taija, Detmar, Michael, Moser, Markus, Lämmermann, Tim, Halin, Cornelia

“…Dendritic cell (DC) migration to draining lymph nodes (dLNs) is a slow process that is believed to begin with DCs approaching and entering into afferent…”
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Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis by Proulx, Steven T, Luciani, Paola, Christiansen, Ailsa, Karaman, Sinem, Blum, Katrin S, Rinderknecht, Matthias, Leroux, Jean-Christophe, Detmar, Michael

“…Abstract Tumor lymphangiogenesis promotes metastatic cancer spread to lymph nodes and beyond. However, the potential remodeling and functionality of…”
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T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions by Teijeira, Alvaro, Hunter, Morgan C., Russo, Erica, Proulx, Steven T., Frei, Thomas, Debes, Gudrun F., Coles, Marc, Melero, Ignacio, Detmar, Michael, Rouzaut, Ana, Halin, Cornelia

“…T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing…”
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Activation of the VEGFR-3 Pathway by VEGF-C Attenuates UVB-Induced Edema Formation and Skin Inflammation by Promoting Lymphangiogenesis by Kajiya, Kentaro, Sawane, Mika, Huggenberger, Reto, Detmar, Michael

“…We have previously demonstrated that UVB irradiation resulted in impaired function of cutaneous lymphatic vessels, suggesting a crucial role of lymphatic…”
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An Important Role of VEGF-C in Promoting Lymphedema Development by Gousopoulos, Epameinondas, Proulx, Steven T., Bachmann, Samia B., Dieterich, Lothar C., Scholl, Jeannette, Karaman, Sinem, Bianchi, Roberta, Detmar, Michael

“…Secondary lymphedema is a common complication after cancer treatment, but the pathomechanisms underlying the disease remain unclear. Using a mouse tail…”
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