Search Results - "Detlev Boison"

Adenosine dysfunction in epilepsy by Boison, Detlev

“…Extracellular levels of the brain's endogenous anticonvulsant and neuroprotectant adenosine largely depend on an astrocyte‐based adenosine cycle, comprised of…”
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Epilepsy and astrocyte energy metabolism by Boison, Detlev, Steinhäuser, Christian

“…Epilepsy is a complex neurological syndrome characterized by neuronal hyperexcitability and sudden, synchronized electrical discharges that can manifest as…”
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Adenosine Metabolism: Emerging Concepts for Cancer Therapy by Boison, Detlev, Yegutkin, Gennady G.

“…Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor escape from the host immune system. Major gaps in knowledge that impede…”
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Specialty Grand Challenge for Brain Disease Mechanisms by Boison, Detlev

“…[...]there is a major unmet need to identify treatment options, which are disease modifying and thereby affect fundamental mechanisms implicated in pathogenic…”
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Modulators of nucleoside metabolism in the therapy of brain diseases by Boison, Detlev

“…Nucleoside receptors are known to be important targets for a variety of brain diseases. However, the therapeutic modulation of their endogenous agonists by…”
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Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle by Clasadonte, Jerome, Scemes, Eliana, Wang, Zhongya, Boison, Detlev, Haydon, Philip G.

“…Astrocytes produce and supply metabolic substrates to neurons through gap junction-mediated astroglial networks. However, the role of astroglial metabolic…”
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Astrocyte-neuron circuits in epilepsy by Purnell, Benton S., Alves, Mariana, Boison, Detlev

“…The epilepsies are a diverse spectrum of disease states characterized by spontaneous seizures and associated comorbidities. Neuron-focused perspectives have…”
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Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice by Jagannath, Aarti, Varga, Norbert, Dallmann, Robert, Rando, Gianpaolo, Gosselin, Pauline, Ebrahimjee, Farid, Taylor, Lewis, Mosneagu, Dragos, Stefaniak, Jakub, Walsh, Steven, Palumaa, Teele, Di Pretoro, Simona, Sanghani, Harshmeena, Wakaf, Zeinab, Churchill, Grant C., Galione, Antony, Peirson, Stuart N., Boison, Detlev, Brown, Steven A., Foster, Russell G., Vasudevan, Sridhar R.

“…The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also…”
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The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy by Purnell, Benton, Murugan, Madhuvika, Jani, Raja, Boison, Detlev

“…Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in increased adenosine release, thereby constraining excessive…”
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes by Alexander, Stephen PH, Fabbro, Doriano, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Boison, Detlev, Burns, Kathryn Elisa, Dessauer, Carmen, Gertsch, Jürg, Helsby, Nuala Ann, Izzo, Angelo A., Koesling, Doris, Ostrom, Rennolds, Pyne, Nigel J., Pyne, Susan, Russwurm, Michael, Seifert, Roland, Stasch, Johannes‐Peter, Stelt, Mario, Vliet, Albert, Watts, Val, Wong, Szu Shen

“…The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
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Adenosine and Epilepsy: From Therapeutic Rationale to New Therapeutic Strategies by Boison, Detlev

“…Adenosine, as the brain’s endogenous anticonvulsant, is considered to be responsible for seizure arrest and postictal refractoriness. On the other hand,…”
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Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia by Matos, Marco, Shen, Hai-Ying, Augusto, Elisabete, Wang, Yumei, Wei, Catherine J, Wang, Yu Tian, Agostinho, Paula, Boison, Detlev, Cunha, Rodrigo A, Chen, Jiang-Fan

“…Abstract Background Adenosine A2A receptors (A2A R) modulate dopamine and glutamate signaling and thereby may influence some of the psychomotor and cognitive…”
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Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice by Sandau, Ursula S., Yahya, Mayadah, Bigej, Ryan, Friedman, Joseph L., Saleumvong, Bounmy, Boison, Detlev

“…Summary Objective Over one‐third of all patients with epilepsy are refractory to treatment and there is an urgent need to develop new drugs that can prevent…”
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Adenosine hypothesis of schizophrenia – Opportunities for pharmacotherapy by Boison, Detlev, Singer, Philipp, Shen, Hai-Ying, Feldon, Joram, Yee, Benjamin K.

“…Pharmacotherapy of schizophrenia based on the dopamine hypothesis remains unsatisfactory for the negative and cognitive symptoms of the disease. Enhancing…”
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Adenosine and seizure termination: endogenous mechanisms by Boison, Detlev

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Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice by Simon, Matthew, Wang, Marie Xun, Ismail, Ozama, Braun, Molly, Schindler, Abigail G, Reemmer, Jesica, Wang, Zhongya, Haveliwala, Mariya A, O'Boyle, Ryan P, Han, Warren Y, Roese, Natalie, Grafe, Marjorie, Woltjer, Randall, Boison, Detlev, Iliff, Jeffrey J

“…Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer's disease (AD). Aβ is cleared in part by…”
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The impact of methodology on the reproducibility and rigor of DNA methylation data by Boison, Detlev, Masino, Susan A., Lubin, Farah D., Guo, Kai, Lusardi, Theresa, Sanchez, Richard, Ruskin, David N., Ohm, Joyce, Geiger, Jonathan D., Hur, Junguk

“…Epigenetic modifications are crucial for normal development and implicated in disease pathogenesis. While epigenetics continues to be a burgeoning research…”
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Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities by Geiger, Jonathan D, Khan, Nabab, Murugan, Madhuvika, Boison, Detlev

“…The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical…”
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Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy by Gomez-Murcia, Victoria, Sandau, Ursula, Ferry, Barbara, Parrot, Sandrine, Laurent, Cyril, Basquin, Marie, Buée, Luc, Boison, Detlev, Blum, David

“…Epileptic seizures constitute a significant comorbidity of Alzheimer's disease (AD), which are recapitulated in transgenic mouse models of amyloidogenesis…”
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Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation by Xu, Yiming, Wang, Yong, Yan, Siyuan, Yang, Qiuhua, Zhou, Yaqi, Zeng, Xianqiu, Liu, Zhiping, An, Xiaofei, Toque, Haroldo A., Dong, Zheng, Jiang, Xuejun, Fulton, David J., Weintraub, Neal L., Li, Qinkai, Bagi, Zsolt, Hong, Mei, Boison, Detlev, Wu, Chaodong, Huo, Yuqing

“…The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial…”
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