Search Results - "Detke, Mike"

An update and baseline data from the phase 2/3 GAIN trial of COR388 (atuzaginstat), a novel bacterial virulence factor inhibitor for the treatment of Alzheimer’s disease by Detke, Mike

“…Background The novel mechanism of action of atuzaginstat is based on the discovery of gingipains, toxic protease virulence factors from the bacterial pathogen…”
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P4‐542: UTILITY OF SPEECH‐BASED DIGITAL BIOMARKERS FOR EVALUATING DISEASE PROGRESSION IN CLINICAL TRIALS OF ALZHEIMER'S DISEASE by Simpson, William, Kaufman, Liam, Detke, Mike, Lynch, Casey, Butler, Adam, Dominy, Steve

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UTILITY OF SPEECH-BASED DIGITAL BIOMARKERS FOR EVALUATING DISEASE PROGRESSION IN CLINICAL TRIALS OF ALZHEIMER'S DISEASE by Simpson, William, Kaufman, Liam, Detke, Mike, Lynch, Casey, Butler, Adam, Dominy, Steve

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COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients: Human/Human trials: Other by Raha, Debasish, Broce, Sean, Haditsch, Ursula, Rodriguez, Leo, Ermini, Florian, Detke, Mike, Kapur, Shirin, Hennings, Dave, Roth, Theresa, Nguyen, Mai, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve

“…Abstract Background We identified the bacterial pathogen, Porphyromonas gingivalis (Pg), and its protease virulence factors, gingipains, in the brain of…”
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COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients by Raha, Debasish, Broce, Sean, Haditsch, Ursula, Rodriguez, Leo, Ermini, Florian, Detke, Mike, Kapur, Shirin, Hennings, Dave, Roth, Theresa, Nguyen, Mai, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve

“…Background We identified the bacterial pathogen, Porphyromonas gingivalis (Pg), and its protease virulence factors, gingipains, in the brain of patients with…”
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Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss by Ermini, Florian, Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Broce, Sean, Raha, Debasish, Nguyen, Mai, Hancock, Sandy, Cecere, Thomas, Detke, Mike, Kapur, Shirin, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve

“…Background Porphyromonas gingivalis and its proteolytic virulence factors lysine‐gingipain (Kgp) and arginine‐gingipain (Rgp) are emerging as major etiologic…”
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Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss: Molecular and cell biology/synaptic disruption by Ermini, Florian, Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Broce, Sean, Raha, Debasish, Nguyen, Mai, Hancock, Sandy, Cecere, Thomas, Detke, Mike, Kapur, Shirin, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve

“…Abstract Background Porphyromonas gingivalis and its proteolytic virulence factors lysine‐gingipain (Kgp) and arginine‐gingipain (Rgp) are emerging as major…”
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P4‐663: INITIATION OF THE PHASE 2/3 GAIN TRIAL OF COR388, A NOVEL BACTERIAL VIRULENCE FACTOR INHIBITOR FOR THE TREATMENT OF ALZHEIMER'S DISEASE (AD) BASED ON PHASE I A/B SAFETY, PK, BIOMARKER AND EFFICACY DATA by Detke, Mike, Lynch, Casey, Holsinger, Leslie, Kapur, Shirin, Hennings, Dave, Raha, Debasish, Ermini, Florian, Haditsch, Ursula, Ryder, Mark, Goodman, Ira J., Thein, Stephen G., Dominy, Steve

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INITIATION OF THE PHASE 2/3 GAIN TRIAL OF COR388, A NOVEL BACTERIAL VIRULENCE FACTOR INHIBITOR FOR THE TREATMENT OF ALZHEIMER’S DISEASE (AD) BASED ON PHASE I A/B SAFETY, PK, BIOMARKER AND EFFICACY DATA by Detke, Mike, Lynch, Casey, Holsinger, Leslie, Kapur, Shirin, Hennings, Dave, Raha, Debasish, Ermini, Florian, Haditsch, Ursula, Ryder, Mark, Goodman, Ira J., Thein, Stephen G., Dominy, Steve

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P4‐542: UTILITY OF SPEECH‐BASED DIGITAL BIOMARKERS FOR EVALUATING DISEASE PROGRESSION IN CLINICAL TRIALS OF ALZHEIMER'S DISEASE by Simpson, William, Kaufman, Liam, Detke, Mike, Lynch, Casey, Butler, Adam, Dominy, Steve

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