Search Results - "Dessoy, Marco"

Synthesis, Biological Evaluation, and Structure–Activity Relationships of Potent Noncovalent and Nonpeptidic Cruzain Inhibitors as Anti-Trypanosoma cruzi Agents by Ferreira, Rafaela S, Dessoy, Marco A, Pauli, Ivani, Souza, Mariana L, Krogh, Renata, Sales, Ana I. L, Oliva, Glaucius, Dias, Luiz C, Andricopulo, Adriano D

“…The development of cruzain inhibitors has been driven by the urgent need to develop novel and more effective drugs for the treatment of Chagas’ disease…”
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Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi by Koovits, Paul J., Dessoy, Marco A., Matheeussen, An, Maes, Louis, Caljon, Guy, Mowbray, Charles E., Kratz, Jadel M., Dias, Luiz C.

“…[Display omitted] The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline’s recently disclosed open-resource…”
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Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics by Pauli, Ivani, Rezende, Jr, Celso de O, Slafer, Brian W, Dessoy, Marco A, de Souza, Mariana L, Ferreira, Leonardo L G, Adjanohun, Abraham L M, Ferreira, Rafaela S, Magalhães, Luma G, Krogh, Renata, Michelan-Duarte, Simone, Del Pintor, Ricardo Vaz, da Silva, Fernando B R, Cruz, Fabio C, Dias, Luiz C, Andricopulo, Adriano D

“…Cruzain, the main cysteine protease of , plays key roles in all stages of the parasite's life cycle, including nutrition acquisition, differentiation, evasion…”
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Synthesis and Anti-Trypanosoma cruzi Activity of 3‑Cyanopyridine Derivatives by Slafer, Brian W., Dessoy, Marco A., de Oliveira, Ramon G., Mollo, Maria C., Lee, Eun, Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G., Krogh, Renata, Andricopulo, Adriano D., Cruz, Luiza R., Mowbray, Charles E., Kratz, Jadel M., Dias, Luiz C.

“…Chagas disease (CD) is a parasitic neglected tropical disease (NTD) caused by the protozoan Trypanosoma cruzi that affects 6 million people worldwide, often…”
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Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents by Koovits, Paul J, Dessoy, Marco A, Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G, Chelucci, Rafael C, Michelan-Duarte, Simone, Andricopulo, Adriano D, Campbell, Simon, Kratz, Jadel M, Mowbray, Charles E, Dias, Luiz C

“…A series of benzene sulphonamides with good potency and selectivity against Leishmania spp. intracellular amastigotes was identified by high-throughput…”
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Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors by Pauli, Ivani, Ferreira, Leonardo G, de Souza, Mariana L, Oliva, Glaucius, Ferreira, Rafaela S, Dessoy, Marco A, Slafer, Brian W, Dias, Luiz C, Andricopulo, Adriano D

“…Chagas disease is endemic in Latin America and no effective treatment is available. Efforts in drug research have focused on several enzymes from , among which…”
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Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei by Pereira, Glaécia An, Santos, Lucianna H, Wang, Steven C, Martins, Luan C, Villela, Filipe S, Liao, Weiting, Dessoy, Marco A, Dias, Luiz C, Andricopulo, Adriano D, Costa, Mariana Af, Nagem, Ronaldo Ap, Caffrey, Conor R, Liedl, Klaus R, Caffarena, Ernesto R, Ferreira, Rafaela S

“…Limitations in available therapies for trypanosomiases indicate the need for improved medicines. Cysteine proteases cruzain and rhodesain are validated targets…”
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Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration by Valli, Marilia, Altei, Wanessa, dos Santos, Ricardo, de Lucca Jr, Emilio, Dessoy, Marco, Pioli, Renan, Cotinguiba, Fernando, Cachet, Xavier, Michel, Sylvie, Furlan, Maysa, Dias, Luiz, Andricopulo, Adriano, Bolzani, Vanderlan

“…Piperlongumine is a natural amide alkaloid isolated from several species of Piper and is described in the literature as selectively cytotoxic to several cancer…”
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Analysis of cytokinin nucleotides by capillary zone electrophoresis with diode array and mass spectrometric detection in a recombinant enzyme in vitro reaction by Béres, Tibor, Gemrotová, Markéta, Tarkowski, Petr, Ganzera, Markus, Maier, Vítězslav, Friedecký, David, Dessoy, Marco A., Wessjohann, Ludger A., Spíchal, Lukáš, Strnad, Miroslav, Doležal, Karel

“…[Display omitted] ► We describe a capillary electrophoresis based enzymatic assay. ► Cytokinin mono-, di- and triphosphates were separated by CE for the first…”
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Proposed Mechanism for the Reductive Ring Opening of the Cyclodiphosphate MEcPP, a Crucial Transformation in the New DXP/MEP Pathway to Isoprenoids Based on Modeling Studies and Feeding Experiments by Brandt, Wolfgang, Dessoy, Marco A, Fulhorst, Michael, Gao, Wenyun, Zenk, Meinhart H, Wessjohann, Ludger A

“…Experimental and theoretical investigations concerning the second-to-last step of the DXP/MEP pathway in isoprenoid biosynthesis in plants are reported. The…”
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Doenças tropicais negligenciadas: uma nova era de desafios e oportunidades by Dias, Luiz C., Dessoy, Marco A., Guido, Rafael V. C., Oliva, Glaucius, Andricopulo, Adriano D.

“…In an article recently published in Química Nova, entitled "Chemistry Without Borders" ("Química Sem Fronteiras") [Pinto, A. C.; Zucco, C.; Galembeck, F.;…”
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(E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate: An Intermediate in the Formation of Terpenoids in Plant Chromoplasts by Gao, Wenyun, Loeser, Reik, Raschke, Maja, Dessoy, Marco A., Fulhorst, Michael, Alpermann, Henriette, Wessjohann, Ludger A., Zenk, Meinhart H.

“…The missing link in the new deoxyxylulose phosphate metabolic pathway leading to the biosynthesis of plant terpenoids has been identified. The intermediate…”
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An efficient method for the preparation of silyl esters of diphosphoric, phosphoric, and phosphorous acid by Wessjohann, Ludger A., Dessoy, Marco A.

“…Trialkylsilylesters of diphosphate, phosphate, and phosphite are accessible in bulk in quantitative yield by a new triphasic reaction system. Partial/full…”
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Identification of Enterodiol as a Masker for Caffeine Bitterness by Using a Pharmacophore Model Based on Structural Analogues of Homoeriodictyol by Ley, Jakob P, Dessoy, Marco, Paetz, Susanne, Blings, Maria, Hoffmann-Lücke, Petra, Reichelt, Katharina V, Krammer, Gerhard E, Pienkny, Silke, Brandt, Wolfgang, Wessjohann, Ludger

“…Starting from previous structure–activity relationship studies of taste modifiers based on homoeriodictyol, dihydrochalcones, deoxybenzoins, and…”
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Migration of secondary tert-butyldimethylsilyl groups in cyclomalto-heptaose and -octaose derivatives by Icheln, Detlef, Gehrcke, Bärbel, Piprek, Yvonne, Mischnick, Petra, König, Wilfried A., Dessoy, Marco A., Morel, Ademir F.

“…When 2,6-di- O- tert-butyldimethylsilylated cyclomalto-oligosaccharides (cyclodextrins) are treated with allyl or methyl iodide and NaH in dry tetrahydrofuran,…”
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Quimioterapia da doença de Chagas: estado da arte e perspectivas no desenvolvimento de novos fármacos by Dias, Luiz C., Dessoy, Marco A., Silva, Jean Jerley N., Thiemann, Otavio H., Oliva, Glaucius, Andricopulo, Adriano D.

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(E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate: An Intermediate in the Formation of Terpenoids in Plant Chromoplasts by Gao, Wenyun, Loeser, Reik, Raschke, Maja, Dessoy, Marco A., Fulhorst, Michael, Alpermann, Henriette, Wessjohann, Ludger A., Zenk, Meinhart H.

“…Ein weißer Fleck im neuen Desoxyxylulosephosphat‐Biosyntheseweg befand sich bisher zwischen dem cyclischen Diphosphat 1 und den Isopren‐Grundbausteinen…”
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Quimioterapia da doença de Chagas: estado da arte e perspectivas no desenvolvimento de novos fármacos Chemotherapy of Chagas' disease: state of the art and perspectives for the development of new drugs by Luiz C. Dias, Marco A. Dessoy, Jean Jerley N. Silva, Otavio H. Thiemann, Glaucius Oliva, Adriano D. Andricopulo

“…Neglected diseases are a major global cause of illness, long-term disability and death. Chagas' disease is a parasitic infection widely distributed throughout…”
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In Vitro and In Vivo Production of New Aminocoumarins by a Combined Biochemical, Genetic, and Synthetic Approach by Galm, Ute, Dessoy, Marco Aurélio, Schmidt, Jürgen, Wessjohann, Ludger A., Heide, Lutz

“…The aminocoumarin antibiotics clorobiocin, novobiocin, and coumermycin A 1 are inhibitors of bacterial gyrase. Their chemical structures contain amide bonds,…”
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Heptakis(6-O-ethyl-2,3-O-pentyl)-β-cyclodextrin: A New Chiral Stationary Phases for Capillary GC by Dessoy, Marco A., Moreira, Jane de J., Ethur, Eduardo M., Dessoy, Emília Carolina M., Morel, Ademir F.

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