Search Results - "Desselle, Ariane"

A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity by Alvarez-Rueda, Nidia, Desselle, Ariane, Cochonneau, Denis, Chaumette, Tanguy, Clemenceau, Béatrice, Leprieur, Stéphanie, Bougras, Gwenola, Supiot, Stéphane, Mussini, Jean-Marie, Barbet, Jacques, Saba, Julie, Paris, François, Aubry, Jacques, Birklé, Stéphane

“…Monoclonal antibodies (mAb) against GD2 ganglioside have been shown to be effective for the treatment of neuroblastoma. Beneficial actions are, however,…”
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1370 Anti-PD-1/IL-7v immunocytokine favors proliferation & survival of TCF1+ stem like memory T cells and a durable in vivo efficacy in monotherapy or using combinatorial strategy by Morello, Aurore, Durand, Justine, Seite, Margaux, Girault, Isabelle, Teppaz, Geraldine, Thepenier, Virginie, Batty, Cecile, Desselle, Ariane, Wilhelm, Emmanuelle, Malloci, Marine, Mary, Caroline, Poirier, Nicolas

“…BackgroundImmunocytokines can strengthen anti-PD-(L)1 therapy by promoting T-cell survival, but their shortened half-life and systemic toxicity limit their…”
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852 Modified-epitope-based vaccine (OSE2101) combined with anti-PD-1/IL-7v bispecific antibody sustains long-lasting tumor specific antigen memory T cell response in vivo by Lyssia, Belarif, Taurelle, Julien, Desselle, Ariane, Durand, Justine, Seite, Margaux, Mary, Caroline, Teppaz, Geraldine, Thepenier, Virginie, Batty, Cecile, Vasseur, Berangere, Vandewalle, Thomas, Cordonnier, Laurie, Morello, Aurore, Poirier, Nicolas

“…BackgroundOSE2101 is a cancer vaccine composed of 9 optimized epitopes of 5 different tumor-associated antigens (TAAs) CEA, p53, HER-2/neu, MAGE2, MAGE3…”
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493 Identification of different classes of antagonist monoclonal antibodies targeting the myeloid checkpoint CLEC-1 and their associated anti-tumoral in vivo efficacies in humanized preclinical models by Baccelli, Irène, Mary, Caroline, Neyton, Stéphanie, Deramé, Mylène, Drouin, Marion, Teppaz, Geraldine, Wilhelm, Emmanuelle, Girault, Isabelle, Gauttier, Vanessa, Thepenier, Virginie, Batty, Cecile, Biteau, Kevin, Desselle, Ariane, Colonello, Marion, Taurelle, Julien, Malloci, Marine, Chiffoleau, Elise, Poirier, Nicolas

“…BackgroundThe c-type lectin receptor CLEC-1 is a pattern recognition receptor1 expressed by endothelial and myeloid cells in mice, non-human primates, and…”
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Anti-Gb3 monoclonal antibody inhibits angiogenesis and tumor development by Desselle, Ariane, Chaumette, Tanguy, Gaugler, Marie-Hélène, Cochonneau, Denis, Fleurence, Julien, Dubois, Nolwenn, Hulin, Philippe, Aubry, Jacques, Birklé, Stéphane, Paris, François

“…Inhibiting the growth of tumor vasculature represents one of the relevant strategies against tumor progression. Between all the different pro-angiogenic…”
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212 CLEC-1 is a novel myeloid immune checkpoint for cancer immunotherapy limiting tumor cells phagocytosis and synergizing with tumor-targeted antibodies by Gauttier, Vanessa, Drouin, Marion, Pengam, Sabrina, Saenz, Javier, Evrard, Bérangère, Mary, Caroline, Teppaz, Géraldine, Desselle, Ariane, Thépénier, Virginie, Wilhelm, Emmanuelle, Chiffoleau, Elise, Poirier, Nicolas

“…BackgroundMyeloid cells represent one of the most abundant immune cell types in solid tumors that impede myeloid phagocytosis by triggering ‘don’t eat me’ and…”
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Abstract 1636: CLEC-1 is a novel myeloid immune checkpoint for cancer immunotherapy limiting tumor cells phagocytosis and tumor antigen cross-presentation by Gauttier, Vanessa, Pengam, Sabrina, Drouin, Marion, Saenz, Javier, Evrard, Bérangère, Biteau, Kevin, Mary, Caroline, Teppaz, Géraldine, Desselle, Ariane, Thépénier, Virginie, Wilhelm, Emmanuelle, Chiffoleau, Elise, Poirier, Nicolas

“…Abstract Myeloid cells represent one of the most abundant immune cell types in solid tumors that impede myeloid phagocytosis by triggering “don't eat me” and…”
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Nanofitin as a New Molecular-Imaging Agent for the Diagnosis of Epidermal Growth Factor Receptor Over-Expressing Tumors by Goux, Marine, Becker, Guillaume, Gorré, Harmony, Dammicco, Sylvestre, Desselle, Ariane, Egrise, Dominique, Leroi, Natacha, Lallemand, François, Bahri, Mohamed Ali, Doumont, Gilles, Plenevaux, Alain, Cinier, Mathieu, Luxen, André

“…Epidermal growth-factor receptor (EGFR) is involved in cell growth and proliferation and is over-expressed in malignant tissues. Although anti-EGFR-based…”
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Abstract 2955: Anti-PD-1/IL-7v bispecific antibody promotes TCF1+ stem like CD8 T cells expansion and long-lasting in vivo efficacy by Morello, Aurore, Seite, Margaux, Durand, Justine, Girault, Isabelle, Mary, Caroline, Thepenier, Virginie, Teppaz, Geraldine, Wilhem, Emmanuelle, Desselle, Ariane, Poirier, Nicolas

“…Abstract Immunocytokines can strengthen anti PD(L)1 therapy by promoting T-cell survival, but their shortened half-life and systemic toxicity limit clinical…”
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Abstract 6365: TRIM21 is a novel endogenous partner of the inhibitory myeloid checkpoint CLEC-1 involved in tumor antigen cross-presentation by Baccelli, Irene, Gauttier, Vanessa, Drouin, Marion, Mary, Caroline, Girault, Isabelle, Wilhelm, Emmanuelle, Pengam, Sabrina, Teppaz, Géraldine, Taurelle, Julien, Desselle, Ariane, Thepenier, Virginie, Poirier, Nicolas, Chiffoleau, Elise

“…Abstract Myeloid cells represent the most abundant immune component of the tumor microenvironment, where they often assume immunosuppressive roles. Therefore,…”
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Abstract 6342: Anti-tumor in vivo efficacy of different classes of anti-CLEC-1 myeloid checkpoint antibodies in monotherapy and in combination with chemotherapeutic agents by Morello, Aurore, Deramé, Mylène, Drouin, Marion, Wilhelm, Emmanuelle, Neyton, Stéphanie, Baccelli, Irène, Mary, Caroline, Gauttier, Vanessa, Girault, Isabelle, Biteau, Kévin, Batty, Cécile, Teppaz, Géraldine, Desselle, Ariane, Colonello, Marion, Malloci, Marine, Chiffoleau, Elise, Poirier, Nicolas

“…Abstract The c-type lectin receptor CLEC-1 is a pattern recognition receptor [1] expressed by endothelial and myeloid cells in mice, non-human primates, and…”
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230 Preclinical efficacy of CLEC-1 antagonist as novel myeloid immune checkpoint therapy for oncology by Gauttier, Vanessa, Drouin, Marion, Pengam, Sabrina, Saenz, Javier, Evrard, Bérangère, Neyton, Stéphanie, Mary, caroline, Teppaz, Géraldine, Desselle, Ariane, Thépénier, Virginie, Wilhelm, Emmanuelle, Poirier, Nicolas, Chiffoleau, Elise

“…Background C-type lectin receptors (CLRs) are powerful pattern recognition receptors shaping immune cell-mediated tissue damage by positively or negatively…”
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CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy by Drouin, Marion, Saenz, Javier, Gauttier, Vanessa, Evrard, Berangere, Teppaz, Geraldine, Pengam, Sabrina, Mary, Caroline, Desselle, Ariane, Thepenier, Virginie, Wilhelm, Emmanuelle, Merieau, Emmanuel, Ligeron, Camille, Girault, Isabelle, Lopez, Maria-Dolores, Fourgeux, Cynthia, Sinha, Debajyoti, Baccelli, Irene, Moreau, Aurelie, Louvet, Cedric, Josien, Regis, Poschmann, Jeremie, Poirier, Nicolas, Chiffoleau, Elise

“…Tumors exploit numerous immune checkpoints, including those deployed by myeloid cells to curtail antitumor immunity. Here, we show that the C-type lectin…”
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Abstract 6358: CLEC-1 inhibitory myeloid checkpoint blockade enhances antitumor responses and tumor phagocytosis by macrophages by Gauttier, Vanessa, Baccelli, Irène, Drouin, Marion, Girault, Isabelle, Pengam, Sabrina, Wilhelm, Emmanuelle, Saenz, Javier, Taurelle, Julien, Mérieau, Emmanuel, Evrard, Bérangère, Mary, Caroline, Teppaz, Géraldine, Desselle, Ariane, Thépénier, Virginie, Poirier, Nicolas, Chiffoleau, Elise

“…Abstract Myeloid cells represent the most abundant immune component of the tumor microenvironment, where they often assume immunosuppressive roles. Therefore,…”
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Inhibition of tumor angiogenesis by globotriaosylceramide immunotargeting by Birklé, Stéphane, Desselle, Ariane, Chaumette, Tanguy, Gaugler, Marie-Hélène, Cochonneau, Denis, Fleurence, Julien, Dubois, Nolwenn, Hulin, Philippe, Aubry, Jacques, Paris, François

“…Current antiangiogenic immunotherapeutic strategies mainly focus on the blockade of circulating cytokines or receptors that are overexpressed by endothelial…”
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Inhibition of tumor angiogenesis by globotriaosylceramide immunotargeting by Birklé, S., Desselle, A., Chaumette, T., Gaugler, M.-H., Cochonneau, D., Fleurence, J., Dubois, N., Hulin, P., Aubry, J., Paris, F.

“…Current antiangiogenic immunotherapeutic strategies mainly focus on the blockade of circulating cytokines or receptors that are overexpressed by endothelial…”
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Nanofitin as a New Molecular-Imaging Agent for the Diagnosis of 2 Epidermal Growth Factor Receptor Over-Expressing Tumors by Goux, Marine, Becker, Guillaume, Gorré, Harmony, Dammicco, Sylvestre, Desselle, Ariane, Egrise, Dominique, Leroi, Natacha, Lallemand, François, Bahri, Mohamed Ali, Doumont, Gilles, Plenevaux, Alain, Cinier, Mathieu, Luxen, André

“…Epidermal growth-factor receptor (EGFR) is involved in cell growth and proliferation and is over-expressed in malignant tissues. Although anti-EGFR-based…”
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