Search Results - "Dessein, Alain"

Reply to Watschinger et al by Marquet, Sandrine, Dessein, Alain J

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Genetic algorithms identify individuals with high risk of severe liver disease caused by schistosomes by Dessein, Hélia, Duflot, Nicolas, Romano, Audrey, Opio, Christopher, Pereira, Valeria, Mola, Carla, Kabaterene, Narcis, Coutinho, Ana, Dessein, Alain

“…Schistosomes induce severe hepatic disease, which is fatal in 2–10% of cases, mortality being higher in cases of co-infection with HBV or HCV. Hepatic disease…”
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Correction to: Genetic algorithms identify individuals with high risk of severe liver disease caused by schistosomes by Dessein, Hélia, Duflot, Nicolas, Romano, Audrey, Opio, Christopher, Pereira, Valeria, Mola, Carla, Kabaterene, Narcis, Coutinho, Ana, Dessein, Alain

“…In the original article publication, the affiliation of the author Ana Coutinho is incorrect…”
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Exome Sequencing Identifies Two Variants of the Alkylglycerol Monooxygenase Gene as a Cause of Relapses in Visceral Leishmaniasis in Children, in Sudan by Marquet, Sandrine, Bucheton, Bruno, Reymond, Camille, Argiro, Laurent, EL-Safi, Sayda Hassan, Kheir, Musa Mohamed, Desvignes, Jean-Pierre, Béroud, Christophe, Mergani, Adil, Hammad, Awad, Dessein, Alain J.

“…Background. Visceral leishmaniasis (kala-azar, KA) is the most severe form of leishmaniasis, characterized by fever, weight loss, hepatosplenomegaly, and…”
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IL‐22 and IL‐22 binding protein (IL‐22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections by Sertorio, Mathieu, Hou, Xunya, Carmo, Rodrigo F., Dessein, Hélia, Cabantous, Sandrine, Abdelwahed, Mohammed, Romano, Audrey, Albuquerque, Fernanda, Vasconcelos, Luydson, Carmo, Theomira, Li, Jun, Varoquaux, Arthur, Arnaud, Violaine, Oliveira, Pablo, Hamdoun, Anas, He, Hongbin, Adbelmaboud, Suzan, Mergani, Adil, Zhou, Jie, Monis, Ahmed, Pereira, Leila Beltrao, Halfon, Philippe, Bourlière, Marc, Parana, Raymundo, dos Reis, Mitermayer, Gonnelli, David, Moura, Patricia, Elwali, Nasr Eldin, Argiro, Laurent, Li, Yuesheng, Dessein, Alain

“…Interleukin (IL)‐22 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate immunity, tissue protection, and repair. IL‐22 may also cause…”
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Low plasma haptoglobin is a risk factor for life-threatening childhood severe malarial anemia and not an exclusive consequence of hemolysis by Abah, Samuel Eneọjọ, Burté, Florence, Marquet, Sandrine, Brown, Biobele J., Akinkunmi, Francis, Oyinloye, Gbeminiyi, Afolabi, Nathaniel K., Omokhodion, Samuel, Lagunju, Ikeoluwa, Shokunbi, Wuraola A., Wahlgren, Mats, Dessein, Hélia, Argiro, Laurent, Dessein, Alain J., Noyvert, Boris, Hunt, Lilian, Elgar, Greg, Sodeinde, Olugbemiro, Holder, Anthony A., Fernandez-Reyes, Delmiro

“…Severe Malarial Anemia (SMA), a life-threatening childhood Plasmodium falciparum malaria syndrome requiring urgent blood transfusion, exhibits inflammatory and…”
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Human leukocyte antigen-G 3′ untranslated region polymorphism +3142G/C (rs1063320) and haplotypes are associated with manifestations of the American Tegumentary Leishmaniasis in a Northeastern Brazilian population by Sonon, Paulin, Gomes, Renan G., Brelaz-de-Castro, Maria C.A., da Costa, Laís A.B., Pereira, Valéria R.A., de Brito, Maria E.F., Dessein, Alain J.J., Diniz, George T.N., Donadi, Eduardo A., Lucena-Silva, Norma

“…While the role of cytokine genes has been well documented in the context of Leishmania (Viannia) braziliensis infection, no studies have addressed the…”
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Genotype combinations of two IL4 polymorphisms influencing IL-4 plasma levels are associated with different risks of severe malaria in the Malian population by Cabantous, Sandrine, Ranque, Stéphane, Poudiougou, Belco, Traore, Abdoulaye, Berbache, Sofiane, Vitte, Joana, Bongrand, Pierre, Doumbo, Ogobara, Dessein, Alain. J., Abel, Laurent, Marquet, Sandrine

“…We have previously found that children heterozygous for IL4 variable-number tandem repeat (VNTR) (rs8179190) or IL4-33 (rs2070874) variants were at risk for…”
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American tegumentary leishmaniasis: mRNA expression for Th1 and Treg mediators are predominant in patients with recent active disease by Souza, Marina A, Almeida, Thays M, Castro, Maria Carolina A.B, Oliveira-Mendes, Andresa P, Almeida, Amanda F, Oliveira, Beatriz C, Rocha, Lucas F, Medeiros, Angela C.R, Brito, Maria E.F, Dessein, Alain J.J, Pereira, Valéria R.A

“…Abstract Besides the Th1 × Th2 paradigm, Treg and Th17 cytokines may play a role in the response to American tegumentary leishmaniasis. Considering the…”
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Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction by Marquet, Sandrine, Dessein, Alain, Chevillard, Christophe, Traore, Abdoulaye M., Oumar, Aboubacar A., Barry, Abdoulaye, Bergon, Aurélie, Poudiougou, Belco, Cabantous, Sandrine, Doumbo, Ogobara K.

“…Background. Cerebral malaria (CM), a reversible encephalopathy affecting young children, is a medical emergency requiring rapid clinical assessment and…”
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Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: A cross-sectional study by Carvalho Santos, Joelma, Dória Batista, Andrea, Maria Mola Vasconcelos, Carla, Souza Lemos, Roberto, Romão de Souza Junior, Valter, Dessein, Alain, Dessein, Hélia, Maria Lucena Montenegro, Silvia, Pessoa Almeida Lopes, Edmundo, Lúcia Coutinho Domingues, Ana

“…ARFI elastrography has been used as a noninvasive method to assess the severity of liver fibrosis in viral hepatitis, although with few studies in…”
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Genetic Evidence for the Aggravation of Plasmodium falciparum Malaria by Interleukin 4 by Cabantous, Sandrine, Poudiougou, Belco, Oumar, Aboubacar A., Traore, Abdoualye, Barry, Abdoulaye, Vitte, Joana, Bongrand, Pierre, Marquet, Sandrine, Doumbo, Ogobara, Dessein, Alain J.

“…BackgroundSevere malaria (SM) due to Plasmodium falciparum causes millions of child deaths in sub-Saharan Africa. It comprises a variety of clinical disorders,…”
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FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly by Romano, Audrey, Hou, Xunya, Sertorio, Mathieu, Dessein, Hélia, Cabantous, Sandrine, Oliveira, Pablo, Li, Jun, Oyegue, Sandrine, Arnaud, Violaine, Luo, Xinsong, Daujat-Chavanieu, Martine, Chavanieu, Martine, Mariani, Odette, Sastre, Xavier, Dombey, Anne-Marie, He, Hongbin, Li, Yuesheng, Dessein, Alain

“…Schistosoma eggs cause chronic liver inflammation and a complex disease characterized by hepatic fibrosis (HF) and splenomegaly (SplM). FOXP3+ Tregs could…”
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The IL17F and IL17RA Genetic Variants Increase Risk of Cerebral Malaria in Two African Populations by Marquet, Sandrine, Conte, Ianina, Poudiougou, Belco, Argiro, Laurent, Cabantous, Sandrine, Dessein, Hélia, Burté, Florence, Oumar, Aboubacar A, Brown, Biobele J, Traore, Abdoualye, Afolabi, Nathaniel K, Barry, Abdoulaye, Omokhodion, Samuel, Ndoumbe, Ursule Ewanda, Shokunbi, Wuraola A, Sodeinde, Olugbemiro, Doumbo, Ogobara, Fernandez-Reyes, Delmiro, Dessein, Alain J

“…Cerebral malaria (CM) is a neurological complication of infection with Plasmodium falciparum that is partly caused by cytokine-mediated inflammation. It is not…”
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IL2RA genetic variants reduce IL-2-dependent responses and aggravate human cutaneous leishmaniasis by Oliveira, Pablo R S, Dessein, Hélia, Romano, Audrey, Cabantous, Sandrine, de Brito, Maria E F, Santoro, Ferrucio, Pitta, Maira G R, Pereira, Valéria, Pontes-de-Carvalho, Lain C, Rodrigues, Jr, Virmondes, Rafati, Sima, Argiro, Laurent, Dessein, Alain J

“…The outcome of Leishmania infections varies substantially, depending on the host and the parasite strain; infection may be asymptomatic or cause mild or severe…”
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A Functional IL22 Polymorphism (rs2227473) Is Associated with Predisposition to Childhood Cerebral Malaria by Marquet, Sandrine, Conte, Ianina, Poudiougou, Belco, Argiro, Laurent, Dessein, Hélia, Couturier, Charlène, Burté, Florence, Oumar, Aboubacar A., Brown, Biobele J., Traore, Abdoualye, Afolabi, Nathaniel K., Barry, Abdoulaye, Omokhodion, Samuel, Shokunbi, Wuraola A., Sodeinde, Olugbemiro, Doumbo, Ogobara, Fernandez-Reyes, Delmiro, Dessein, Alain J.

“…Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection. This encephalopathy is characterized by coma and is thought to result from…”
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Clinical utility of polygenic risk scores for predicting NAFLD disorders by Dessein, Alain

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Cytokine regulation of periportal fibrosis in humans infected with Schistosoma mansoni: IFN-gamma is associated with protection against fibrosis and TNF-alpha with aggravation of disease by Henri, Sandrine, Chevillard, Christophe, Mergani, Adil, Paris, Patricia, Gaudart, Jean, Camilla, Christophe, Dessein, Hélia, Montero, Felix, Elwali, Nasr-Eldin M A, Saeed, Osman K, Magzoub, Mubarak, Dessein, Alain J

“…Hepatic periportal fibrosis, which affects 5-10% of subjects infected by Schistosoma mansoni, is caused by the T cell-dependent granuloma that develop around…”
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Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis by Rodrigues, Virmondes, Vinícius da Silva, Marcos, Dessein, Alain, Dessein, Helia, Argiro, Laurent, Castellano, Lúcio Roberto, Correia, Dalmo

“…Interleukin-10 overproduction has been associated with worse prognosis in human cutaneous leishmaniasis, while IFN-γ-dependent responses are associated with…”
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Correction: In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosmiasis by Masi, Brice, Perles-Barbacaru, Teodora-Adriana, Laprie, Caroline, Dessein, Helia, Bernard, Monique, Dessein, Alain, Viola, Angèle

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