Search Results - "Desrosiers, Mélissa"

Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates by Gauvain, Gregory, Akolkar, Himanshu, Chaffiol, Antoine, Arcizet, Fabrice, Khoei, Mina A., Desrosiers, Mélissa, Jaillard, Céline, Caplette, Romain, Marre, Olivier, Bertin, Stéphane, Fovet, Claire-Maelle, Demilly, Joanna, Forster, Valérie, Brazhnikova, Elena, Hantraye, Philippe, Pouget, Pierre, Douar, Anne, Pruneau, Didier, Chavas, Joël, Sahel, José-Alain, Dalkara, Deniz, Duebel, Jens, Benosman, Ryad, Picaud, Serge

“…Vision restoration is an ideal medical application for optogenetics, because the eye provides direct optical access to the retina for stimulation. Optogenetic…”
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Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina by Sengupta, Abhishek, Chaffiol, Antoine, Macé, Emilie, Caplette, Romain, Desrosiers, Mélissa, Lampič, Maruša, Forster, Valérie, Marre, Olivier, Lin, John Y, Sahel, José‐Alain, Picaud, Serge, Dalkara, Deniz, Duebel, Jens

“…Targeting the photosensitive ion channel channelrhodopsin‐2 (ChR2) to the retinal circuitry downstream of photoreceptors holds promise in treating vision loss…”
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Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice by Macé, Emilie, Caplette, Romain, Marre, Olivier, Sengupta, Abhishek, Chaffiol, Antoine, Barbe, Peggy, Desrosiers, Mélissa, Bamberg, Ernst, Sahel, Jose-Alain, Picaud, Serge, Duebel, Jens, Dalkara, Deniz

“…Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of retinal…”
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A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina by Chaffiol, Antoine, Caplette, Romain, Jaillard, Céline, Brazhnikova, Elena, Desrosiers, Mélissa, Dubus, Elisabeth, Duhamel, Laëtitia, Macé, Emilie, Marre, Olivier, Benoit, Patrick, Hantraye, Philippe, Bemelmans, Alexis-Pierre, Bamberg, Ernst, Duebel, Jens, Sahel, José-Alain, Picaud, Serge, Dalkara, Deniz

“…The majority of inherited retinal degenerations converge on the phenotype of photoreceptor cell death. Second- and third-order neurons are spared in these…”
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Repair of Rhodopsin mRNA by Spliceosome-Mediated RNA Trans-Splicing: A New Approach for Autosomal Dominant Retinitis Pigmentosa by Berger, Adeline, Lorain, Stéphanie, Joséphine, Charlène, Desrosiers, Melissa, Peccate, Cécile, Voit, Thomas, Garcia, Luis, Sahel, José-Alain, Bemelmans, Alexis-Pierre

“…The promising clinical results obtained for ocular gene therapy in recent years have paved the way for gene supplementation to treat recessively inherited…”
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Restoration of mGluR6 Localization Following AAV-Mediated Delivery in a Mouse Model of Congenital Stationary Night Blindness by Varin, Juliette, Bouzidi, Nassima, Dias, Miguel Miranda De Sousa, Pugliese, Thomas, Michiels, Christelle, Robert, Camille, Desrosiers, Melissa, Sahel, José-Alain, Audo, Isabelle, Dalkara, Deniz, Zeitz, Christina

“…Complete congenital stationary night blindness (cCSNB) is an incurable inherited retinal disorder characterized by an ON-bipolar cell (ON-BC) defect. GRM6…”
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Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8 by Khabou, Hanen, Desrosiers, Mélissa, Winckler, Céline, Fouquet, Stéphane, Auregan, Gwenaëlle, Bemelmans, Alexis-Pierre, Sahel, José-Alain, Dalkara, Deniz

“…ABSTRACT Recently, we described a modified AAV2 vector—AAV2‐7m8—having a capsid‐displayed peptide insertion of 10 amino acids with enhanced retinal…”
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Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype by Quinn, Peter M, Mulder, Aat A, Henrique Alves, C, Desrosiers, Mélissa, de Vries, Sharon I, Klooster, Jan, Dalkara, Deniz, Koster, Abraham J, Jost, Carolina R, Wijnholds, Jan

“…Abstract Variations in the human Crumbs homolog-1 (CRB1) gene lead to an array of retinal dystrophies including early onset of retinitis pigmentosa (RP) and…”
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Noninvasive gene delivery to foveal cones for vision restoration by Khabou, Hanen, Garita-Hernandez, Marcela, Chaffiol, Antoine, Reichman, Sacha, Jaillard, Céline, Brazhnikova, Elena, Bertin, Stéphane, Forster, Valérie, Desrosiers, Mélissa, Winckler, Céline, Goureau, Olivier, Picaud, Serge, Duebel, Jens, Sahel, José-Alain, Dalkara, Deniz

“…Intraocular injection of adeno-associated viral (AAV) vectors has been an evident route for delivering gene drugs into the retina. However, gaps in our…”
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Optogenetic targeting of AII amacrine cells restores retinal computations performed by the inner retina by Khabou, Hanen, Orendorff, Elaine, Trapani, Francesco, Rucli, Marco, Desrosiers, Melissa, Yger, Pierre, Dalkara, Deniz, Marre, Olivier

“…Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of inner…”
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A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina by Bemelmans, Alexis-Pierre, Duqué, Sandra, Rivière, Christel, Astord, Stéphanie, Desrosiers, Mélissa, Marais, Thibault, Sahel, José-Alain, Voit, Thomas, Barkats, Martine

“…Widespread gene delivery to the retina is an important challenge for the treatment of retinal diseases, such as retinal dystrophies. We and others have…”
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Cover Image, Volume 113, Number 12, December 2016 by Khabou, Hanen, Desrosiers, Mélissa, Winckler, Céline, Fouquet, Stéphane, Auregan, Gwenaëlle, Bemelmans, Alexis-Pierre, Sahel, José-Alain, Dalkara, Deniz

“…Cover Legend A schematic representation of cell transduction with AAV particles. The cover image, by Deniz Dalkara et al., is based on the Article Insight into…”
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Substantial restoration of night vision in adult mice with congenital stationary night blindness by Varin, Juliette, Bouzidi, Nassima, Gauvain, Gregory, Joffrois, Corentin, Desrosiers, Melissa, Robert, Camille, De Sousa Dias, Miguel Miranda, Neuillé, Marion, Michiels, Christelle, Nassisi, Marco, Sahel, José-Alain, Picaud, Serge, Audo, Isabelle, Dalkara, Deniz, Zeitz, Christina

“…Complete congenital stationary night blindness (cCSNB) due to mutations in TRPM1, GRM6, GPR179, NYX, or leucine-rich repeat immunoglobulin-like transmembrane…”
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495. In Vivo Evidence of trans-Splicing in a Humanized Mouse Model of Autosomal Dominant Retinitis Pigmentosa Induced By Mutation of the Rhodopsin Gene by Berger, Adeline, Lorain, Stéphanie, Joséphine, Charlène, Desrosiers, Mélissa, Peccate, Cécile, Voit, Thomas, Garcia, Luis, Sahel, José-Alain, Bemelmans, Alexis-Pierre

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Characterization of anti-AAV2 neutralizing antibody levels in sheep prior to and following intravitreal AAV2.7m8 injection by Ross, Maya, Sade, Kareen, Obolensky, Alexey, Averbukh, Edward, Desrosiers, Melissa, Rosov, Alexander, Dvir, Hay, Gootwine, Elisha, Banin, Eyal, Dalkara, Deniz, Ofri, Ron

“…Gene augmentation therapy is a promising treatment for incurable, blinding inherited retinal diseases, and intravitreal delivery is being studied as a safe…”
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Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models by Lacomme, Marine, Hales, Sarah C, Brown, Thomas W, Stevanovic, Katarina, Jolicoeur, Christine, Cai, Jenny, Bois, Therence, Desrosiers, Melissa, Dalkara, Deniz, Cayouette, Michel

“…Accumulation of the microtubule-associated protein Tau is linked to neuronal cell death in tauopathies, but how intraneuronal Tau levels are regulated in…”
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A Single Intravenous AAV9 Injection Mediates Bilateral Gene Transfer to the Adult Mouse Retina. e61618 by Bemelmans, Alexis-Pierre, Duque, Sandra, Riviere, Christel, Astord, Stephanie, Desrosiers, Melissa, Marais, Thibault, Sahel, Jose-Alain, Voit, Thomas, Barkats, Martine

“…Widespread gene delivery to the retina is an important challenge for the treatment of retinal diseases, such as retinal dystrophies. We and others have…”
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