Search Results - "Desroches, Nancy"
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3′-Bromo Analogues of Pyrimidine Nucleosides as a New Class of Potent Inhibitors of Mycobacterium tuberculosis
Published in Journal of medicinal chemistry (27-05-2010)“…Tuberculosis (TB) is a major health problem worldwide. We herein report a new class of pyrimidine nucleosides as potent inhibitors of Mycobacterium…”
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2
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors
Published in Bioorganic & medicinal chemistry (01-07-2012)“…Discovery of novel antimycobacterial compounds that work on distinctive targets and by diverse mechanisms of action is urgently required for the treatment of…”
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3
Growth Inhibition of Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium In Vitro: Effect of 1-β-d-2‘-Arabinofuranosyl and 1-(2‘-Deoxy-2‘-fluoro-β-d-2‘-ribofuranosyl) Pyrimidine Nucleoside Analogs
Published in Journal of medicinal chemistry (26-07-2007)“…The resurgence of tuberculosis and the emergence of multiple-drug-resistant strains of Mycobacteria necessitate the search for new classes of antimycobacterial…”
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4
Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs
Published in Bioorganic & medicinal chemistry letters (15-01-2012)“…Several 5-alkyl (or halo)-3′-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis,…”
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5
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2a2-aupa fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors
Published in Bioorganic & medicinal chemistry (01-07-2012)“…Discovery of novel antimycobacterial compounds that work on distinctive targets and by diverse mechanisms of action is urgently required for the treatment of…”
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Journal Article