Search Results - "Desrochers, Linda P"
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Stereospecific Metabolism of R - and S -Warfarin by Human Hepatic Cytosolic Reductases
Published in Drug metabolism and disposition (01-09-2017)“…Coumadin (rac-warfarin) is the most commonly used anticoagulant in the world; however, its clinical use is often challenging because of its narrow therapeutic…”
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Prooxidant and antioxidant properties of salicylaldehyde isonicotinoyl hydrazone iron chelators in HepG2 cells
Published in Biochimica et biophysica acta (01-11-2015)“…Salicylaldehyde isonicotinoyl hydrazone (SIH) is an iron chelator of the aroylhydrazone class that displays antioxidant or prooxidant effects in different…”
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Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites
Published in Archives of biochemistry and biophysics (15-12-2014)“…[Display omitted] •Synthesis of R- and S-7-hydroxywarfarin through green chemistry.•Two novel 7-hydroxywarfarin glucuronides generated by microsomal hepatic…”
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