Search Results - "Despres, Clément"
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Identification of the Tau phosphorylation pattern that drives its aggregation
Published in Proceedings of the National Academy of Sciences - PNAS (22-08-2017)“…Determining the functional relationship between Tau phosphorylation and aggregation has proven a challenge owing to the multiple potential phosphorylation…”
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Characterization of viscoelastic moduli and thickness of isotropic, viscoelastic plates using multi-modal Lamb waves
Published in NDT & E international : independent nondestructive testing and evaluation (01-06-2024)“…This paper presents an approach exploiting the sensitivity of Lamb waves for characterizing the viscoelastic moduli and thickness of plates. The analytical…”
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Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors
Published in ACS chemical biology (21-06-2019)“…Self-assembly of the microtubule-associated protein tau into neurotoxic oligomers, fibrils, and paired helical filaments, and cell-to-cell spreading of these…”
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Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
Published in Frontiers in molecular neuroscience (17-06-2021)“…Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble…”
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Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator
Published in Journal of the American Society for Mass Spectrometry (01-01-2019)“…Native top-down mass spectrometry (MS) and ion mobility spectrometry (IMS) were applied to characterize the interaction of a molecular tweezer assembly…”
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Characterization of complex stiffness and thickness of isotropic, viscoelastic plates using multi-modal Lamb waves
Published in The Journal of the Acoustical Society of America (01-03-2024)“…This paper presents an approach exploiting the sensitivity of Lamb waves for characterizing the mechanical and geometrical properties of plates. The analytical…”
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Semi-synthesis of a tag-free O-GlcNAcylated tau protein by sequential chemoselective ligation
Published in Journal of peptide science (01-05-2016)“…In this paper, the first semi‐synthesis of the Alzheimer‐relevant tau protein carrying an O‐GlcNAcylation is demonstrated by using sequential chemoselective…”
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The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein
Published in Methods in molecular biology (Clifton, N.J.) (2017)“…Nuclear magnetic resonance (NMR) spectroscopy can be used as an analytical tool to investigate posttranslational modifications of protein. NMR is a valuable…”
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NMR Meets Tau: Insights into Its Function and Pathology
Published in Biomolecules (Basel, Switzerland) (07-06-2016)“…In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider…”
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Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
Published in Journal of visualized experiments (27-12-2016)“…Aggregates of the neuronal Tau protein are found inside neurons of Alzheimer's disease patients. Development of the disease is accompanied by increased,…”
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Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
Published in Journal of visualized experiments (27-12-2016)Get full text
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