Search Results - "Desprat, Romain"

Predictable dynamic program of timing of DNA replication in human cells by Desprat, Romain, Thierry-Mieg, Danielle, Lailler, Nathalie, Lajugie, Julien, Schildkraut, Carl, Thierry-Mieg, Jean, Bouhassira, Eric E

“…The organization of mammalian DNA replication is poorly understood. We have produced high-resolution dynamic maps of the timing of replication in human…”
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Generation of patient-specific induced pluripotent stem cell lines with Type 2 Long QT Syndrome and the KCNH2 c.379C > T pathogenic variant by Goual, Lamia, Bounasri, Elisa, Vincenti, Marie, Amédro, Pascal, Desprat, Romain, Bernex, Florence, Lemaitre, Jean-Marc, Pasquié, Jean-Luc, Lacampagne, Alain, Thireau, Jérôme, Meli, Albano C

“…Type 2 Long QT Syndrome (LQT2) is a rare genetic heart rhythm disorder causing life-threatening arrhythmias. We derived induced pluripotent stem cell (iPSC)…”
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Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells by Chang, Chan-Jung, Mitra, Koyel, Koya, Mariko, Velho, Michelle, Desprat, Romain, Lenz, Jack, Bouhassira, Eric E

“…We have previously shown that human embryonic stem cells can be differentiated into embryonic and fetal type of red blood cells that sequentially express three…”
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Reprogramming of Human Peripheral Blood Mononuclear Cell (PBMC) from a patient suffering of a Werner syndrome resulting in iPSC line (REGUi003-A) maintaining a short telomere length by Gatinois, Vincent, Desprat, Romain, Becker, Fabienne, Pichard, Lydiane, Bernex, Florence, Corsini, Carole, Pellestor, Franck, Lemaitre, Jean-Marc

“…Werner syndrome (WS) is a rare human autosomal recessive disorder characterized by early onset of aging-associated diseases, chromosomal instability, and…”
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Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ by Barbeau, Susie, Desprat, Romain, Eymard, Bruno, Martinat, Cécile, Lemaitre, Jean-Marc, Legay, Claire

“…Congenital myasthenic syndromes (CMS) are a class of inherited disorders affecting the neuromuscular junction, a synapse whose activity is essential for…”
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iPSC reprogramming of fibroblasts from a patient with a Rothmund-Thomson syndrome RTS by Gatinois, Vincent, Desprat, Romain, Pichard, Lydiane, Becker, Fabienne, Goldenberg, Alice, Balguerie, Xavier, Pellestor, Franck, Lemaitre, Jean-Marc

“…Rothmund-Thomson Syndrome (RTS) is a rare autosomal recessive disease that manifests several clinical features of accelerated aging. These findings include…”
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iPSC line derived from a Bloom syndrome patient retains an increased disease-specific sister-chromatid exchange activity by Gatinois, Vincent, Desprat, Romain, Becker, Fabienne, Pichard, Lydiane, Bernex, Florence, Isidor, Bertrand, Pellestor, Franck, Lemaitre, Jean-Marc

“…Bloom syndrome is characterized by severe pre- and postnatal growth deficiency, immune abnormalities, sensitivity to sunlight, insulin resistance, and a high…”
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Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis by Pichard, Lydiane, Brondelo, Jean-Marc, Becker, Fabienne, Desprat, Romain, De Ceuninck, Frédéric, Pastoureau, Philippe, Noel, Danielle, Jorgensen, Christian, Lemaitre, Jean-Marc

“…Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting…”
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Generation of catecholaminergic polymorphic ventricular tachycardia patient-specific induced pluripotent stem cell line by Colombani, Sarah, Bernardin, Albin A., Vincenti, Marie, Amédro, Pascal, Desprat, Romain, Bernex, Florence, Lemaitre, Jean-Marc, Pasquié, Jean-Luc, Lacampagne, Alain, Meli, Albano C.

“…Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a genetic disorder characterized by ventricular tachycardia, that can cause the heart to stop…”
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Establishment of a collection of human pluripotent stem cell lines (iPSC) from mesenchymal stem cells (MSC) from three healthy elderly donors by Pichard, Lydiane, Brondello, Jean-Marc, Becker, Fabienne, Desprat, Romain, De Ceuninck, Frédéric, Pastoureau, Philippe, Noel, Daniele, Jorgensen, Christian, Lemaitre, Jean-Marc

“…The study of molecular mechanism driving osteoarticular diseases like osteoarthritis or osteoporosis is impaired by the low accessibility to mesenchymal stem…”
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Generation of three Duchenne Muscular Dystrophy patient-specific induced pluripotent stem cell lines DMD_YoTaz_PhyMedEXp, DMD_RaPer_PhyMedEXp, DMD_OuMen_PhyMedEXp (INSRMi008-A, INSRMi009-A and INSRMi010-A) by Souidi, Monia, Amédro, Pascal, Meyer, Pierre, Desprat, Romain, Lemaître, Jean-Marc, Rivier, François, Lacampagne, Alain, Meli, Albano C.

“…Duchenne Muscular Dystrophy (DMD) is a X-linked degenerative pathology with a prevalence of 1/3600–6000 boys due to the absence of functional dystrophin in…”
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Embryonic stem cells or induced pluripotent stem cells? A DNA integrity perspective by Bai, Qiang, Desprat, Romain, Klein, Bernard, Lemaître, Jean-Marc, De Vos, John

“…Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are two types of pluripotent stem cells that hold great promise for biomedical research…”
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Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator by Desprat, Romain, Bouhassira, Eric E

“…Insertional mutagenesis has emerged as a major obstacle for gene therapy based on vectors that integrate randomly in the genome. Reducing the genotoxicity of…”
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Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features by Cayrou, Christelle, Coulombe, Philippe, Vigneron, Alice, Stanojcic, Slavica, Ganier, Olivier, Peiffer, Isabelle, Rivals, Eric, Puy, Aurore, Laurent-Chabalier, Sabine, Desprat, Romain, Méchali, Marcel

“…In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature remain elusive…”
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A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan by Alle, Quentin, Le Borgne, Enora, Bensadoun, Paul, Lemey, Camille, Béchir, Nelly, Gabanou, Mélissa, Estermann, Fanny, Bertrand‐Gaday, Christelle, Pessemesse, Laurence, Toupet, Karine, Desprat, Romain, Vialaret, Jérôme, Hirtz, Christophe, Noël, Danièle, Jorgensen, Christian, Casas, François, Milhavet, Ollivier, Lemaitre, Jean‐Marc

“…Recent advances in cell reprogramming showed that OSKM induction is able to improve cell physiology in vitro and in vivo. Here, we show that a single short…”
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DNA replication timing alterations identify common markers between distinct progeroid diseases by Rivera-Mulia, Juan Carlos, Desprat, Romain, Trevilla-Garcia, Claudia, Cornacchia, Daniela, Schwerer, Hélène, Sasaki, Takayo, Sima, Jiao, Fells, Tyler, Studer, Lorenz, Lemaitre, Jean-Marc, Gilbert, David M.

“…Progeroid syndromes are rare genetic disorders that phenotypically resemble natural aging. Different causal mutations have been identified, but no molecular…”
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Cellular senescence induces replication stress with almost no affect on DNA replication timing by Rivera-Mulia, Juan Carlos, Schwerer, Hélène, Besnard, Emilie, Desprat, Romain, Trevilla-Garcia, Claudia, Sima, Jiao, Bensadoun, Paul, Zouaoui, Anissa, Gilbert, David M., Lemaitre, Jean-Marc

“…Organismal aging entails a gradual decline of normal physiological functions and a major contributor to this decline is withdrawal of the cell cycle, known as…”
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Cellular senescence induces replication stress without affecting DNA replication timing by Rivera-Mulia, Juan Carlos, Schwerer, Helene, Besnard, Emilie, Desprat, Romain, Trevilla-Garcia, Claudia, Sima, Jiao, Bensadoun, Paul, Zouaoui, Anissa, David, Gilbert, Lemaitre, Jean-Marc

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Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery by Kiprilov, Enko N, Awan, Aashir, Desprat, Romain, Velho, Michelle, Clement, Christian A, Byskov, Anne Grete, Andersen, Claus Y, Satir, Peter, Bouhassira, Eric E, Christensen, Søren T, Hirsch, Rhoda Elison

“…Human embryonic stem cells (hESCs) are potential therapeutic tools and models of human development. With a growing interest in primary cilia in signal…”
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Generation of three Duchenne Muscular Dystrophy patient-specific induced pluripotent 4 stem cell lines DMD_YoTaz_PhyMedEXp, DMD_RaPer_PhyMedEXp, 5 DMD_OuMen_PhyMedEXp (INSRMi008-A, INSRMi009-A and INSRMi010-A) by Souidi, Monia, Amedro, Pascal, Meyer, Pierre, Desprat, Romain, Lemaitre, Jean-Marc, Rivier, Francois, Lacampagne, Alain, Meli, Albano C

“…Duchenne Muscular Dystrophy (DMD) is a X-linked degenerative pathology with a prevalence of 1/3600-6000 boys due to the absence of functional dystrophin in…”
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