Search Results - "Desnoyers, Luc"

Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models by French, Dorothy M, Lin, Benjamin C, Wang, Manping, Adams, Camellia, Shek, Theresa, Hötzel, Kathy, Bolon, Brad, Ferrando, Ronald, Blackmore, Craig, Schroeder, Kurt, Rodriguez, Luis A, Hristopoulos, Maria, Venook, Rayna, Ashkenazi, Avi, Desnoyers, Luc R

“…The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes…”
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Liver-specific Activities of FGF19 Require Klotho beta by Lin, Benjamin C., Wang, Manping, Blackmore, Craig, Desnoyers, Luc R.

“…Hepatocyte function is regulated by members of the fibroblast growth factor (FGF) family of proteins, but little is known about the specific molecular…”
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Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index by Desnoyers, Luc R, Vasiljeva, Olga, Richardson, Jennifer H, Yang, Annie, Menendez, Elizabeth E M, Liang, Tony W, Wong, Chihunt, Bessette, Paul H, Kamath, Kathy, Moore, Stephen J, Sagert, Jason G, Hostetter, Daniel R, Han, Fei, Gee, Jason, Flandez, Jeanne, Markham, Kate, Nguyen, Margaret, Krimm, Michael, Wong, Kenneth R, Liu, Shouchun, Daugherty, Patrick S, West, James W, Lowman, Henry B

“…Target-mediated toxicity constitutes a major limitation for the development of therapeutic antibodies. To redirect the activity of antibodies recognizing…”
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Model‐Informed Drug Development of the Masked Anti‑PD‑L1 Antibody CX‐072 by Stroh, Mark, Green, Michelle, Millard, Bjorn L., Apgar, Joshua F., Burke, John M., Garner, Will, Lu, Hong, Lyman, Susan K., Desnoyers, Luc R., Richardson, Jennifer, Hannah, Alison, Kavanaugh, W. Michael

“…CX‑072 is an anti‑PD‑L1 (programmed death ligand 1) Probody therapeutic (Pb‐Tx) designed to be preferentially activated by proteases in the tumor…”
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FGF19 and cancer by Lin, Benjamin C, Desnoyers, Luc R

“…Fibroblast growth factors (FGFs) and their cognate receptors, FGF receptors (FGFRs), play critical roles in a variety of normal developmental and physiological…”
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Abstract 2975: Development of a probody drug conjugate (PDC) targeting CD71 for the treatment of solid tumors and lymphomas by Singh, Shweta, DuPage, Amy, Yang Weaver, Annie, Sagert, Jason, White, Clayton, Krimm, Michael, Huang, Yuanhui, Diep, Linnea, Tipton, Kim, Liu, Shouchun, Richardson, Jennifer, Kavanaugh, W. Michael, Terrett, Jonathan A., Desnoyers, Luc R.

“…Abstract The targets of Antibody Drug Conjugates (ADCs) have typically been selected by identifying transmembrane antigens that are highly expressed in tumors…”
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Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4 by Bumbaca, Daniela, Wong, Anne, Drake, Elizabeth, Reyes II, Arthur E., Lin, Benjamin C., Stephan, Jean-Philippe, Desnoyers, Luc, Shen, Ben-Quan, Dennis, Mark S.

“…Off-target binding can significantly affect the pharmacokinetics (PK), tissue distribution, efficacy and toxicity of a therapeutic antibody. Herein we describe…”
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WISP-1 Binds to Decorin and Biglycan by Desnoyers, Luc, Arnott, David, Pennica, Diane

“…Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor,Cyr61, NOV) family of growth factors. Structural and…”
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Structural basis and therapeutic implication of the interaction of CCN proteins with glycoconjugates by Desnoyers, Luc

“…The CCN family of growth factors is composed of six structurally related proteins including the cysteine-rich 61 (Cyr61), connective tissue growth factor…”
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Mechanism of Rab Geranylgeranylation:  Formation of the Catalytic Ternary Complex by Anant, Janmeet S, Desnoyers, Luc, Machius, Mischa, Demeler, Borries, Hansen, Jeffrey C, Westover, Kenneth D, Deisenhofer, Johann, Seabra, Miguel C

“…Rab proteins are geranylgeranylated on one or two C-terminal cysteines by Rab geranylgeranyl transferase (RabGGTase). The reaction is dependent on a…”
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Toward a Taxonomy of Visuals in Science Communication by Desnoyers, Luc

“…Purpose: To develop and present a systematic, hierarchical taxonomy of visuals used in science communication, in order to facilitate analysis as well as…”
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Single Prenyl-Binding Site on Protein Prenyl Transferases by Desnoyers, Luc, Seabra, Miguel C.

“…Three distinct protein prenyl transferases, one protein farnesyl transferase (FTase) and two protein geranylgeranyl transferases (GGTase), catalyze prenylation…”
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Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate by Singh, Shweta, Serwer, Laura, DuPage, Amy, Elkins, Kristi, Chauhan, Niharika, Ravn, Matthew, Buchanan, Fritz, Wang, Leyu, Krimm, Michael, Wong, Ken, Sagert, Jason, Tipton, Kimberly, Moore, Stephen J, Huang, Yuanhui, Jang, Andrew, Ureno, Eric, Miller, Adam, Patrick, Sarah, Duvur, Shanti, Liu, Shouchun, Vasiljeva, Olga, Li, Yingchun, Henriques, Tracy, Badagnani, Ilaria, Jeffries, Shawn, Schleyer, Siew, Leanna, Rob, Krebber, Claus, Viswanathan, Sridhar, Desnoyers, Luc, Terrett, Jonathan, Belvin, Marcia, Morgan-Lappe, Susan, Kavanaugh, W Michael, Richardson, Jennifer

“…Probody therapeutics (Pb-Txs) are conditionally activated antibody-drug conjugates (ADCs) designed to remain inactive until proteolytically activated in the…”
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Evidence of intratumoral localization, activation, and immunomodulatory effect of CX-072, a probody therapeutic targeting PD-L1, in a phase I/II trial by Lyman, Susan, Naing, Aung, Zein, Ivan Adiputra, Howng, Bruce, Winter, Michael B., Vasiljeva, Olga, Garner, William, Zheng, Beiyao, Stroh, Mark, Kavanaugh, W Michael, Desnoyers, Luc Roland

“…Abstract only 3108 Background: PROBODY therapeutics (Pb-Tx) are masked antibodies designed to be selectively activated in the tumor microenvironment by…”
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Abstract PS11-07: Intratumoral activation and phase 1/2 clinical activity of CX-2009, a probody drug conjugate (PDC) targeting CD166 by Liu, Joyce F., Zein, Ivan A., Dang, Tam, Lyman, Susan K., Spira, Alexander, Uboha, Nataliya, LoRusso, Patricia, Fidler, Mary J., Meric-Bernstam, Funda, Arkenau, Tobias, Nagasaka, Misako, Desnoyers, Luc R., Kavanaugh, William M., Paton, Virginia, Hannah, Alison, Boni, Valentina

“…Abstract Background: Probody® therapeutics (Pb-Tx) are masked antibodies designed to be selectively activated in the tumor microenvironment by tumor-associated…”
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Novel Non-isotopic Method for the Localization of Receptors in Tissue Sections by Desnoyers, Luc, Simonette, Rebecca A, Vandlen, Richard L, Fendly, Brian M

“…We describe a novel fluorescent method for the detection of receptors for chimeric proteins in tissue sections. The technique was developed using a recombinant…”
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Abstract 2665: Transforming Notch ligands into tumor-antigen targets: A Probody-Drug Conjugate (PDC) targeting Jagged 1 and Jagged 2 by Sagert, Jason, West, Jim, Wong, Chihunt, Desnoyers, Luc, Vasiljeva, Olga, Richardson, Jennifer, Polu, Krishna, Lowman, Henry

“…Abstract The development of antibody drug conjugates (ADC) holds significant promise for improving outcomes in patients with cancer. However, toxicity can…”
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Preliminary results of the first-in-human, dose-finding PROCLAIM-CX-072 trial of the PD-L1 Probody therapeutic CX-072 as monotherapy in patients (pts) with advanced solid tumors by Autio, Karen A., Arkenau, Hendrik-Tobias, O'Neil, Bert H., Bendell, Johanna C., El-Khoueiry, Anthony, Strauss, James, Weise, Amy, Uboha, Nataliya Volodymyrivna, Rizvi, Naiyer A., Zheng, Beiyao, Desnoyers, Luc, Stroh, Mark, Carman, Lori, Humphrey, Rachel W., Will, Matthias, Boni, Valentina, Spira, Alexander I., Naing, Aung

“…Abstract only…”
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Abstract 2664: An anti-Jagged-1/-2 Probody demonstrates inhibition of Jagged-dependent Notch signaling and is activated in multiple types of tumors by Vasiljeva, Olga, Menendez, Elizabeth, Sagert, Jason, West, James W., Richardson, Jennifer, Desnoyers, Luc, Liu, Shouchun, Ford, Judi, Plou, Krishna, Lowman, Henry

“…Abstract Probodies represent a unique class of antibody therapeutics that specifically target therapeutic activity to diseased tissues, such as cancer. A…”
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WISP-1 Is an Osteoblastic Regulator Expressed During Skeletal Development and Fracture Repair by French, Dorothy M., Kaul, Raji J., D'souza, Aloma L., Crowley, Craig W., Bao, Min, Frantz, Gretchen D., Filvaroff, Ellen H., Desnoyers, Luc

“…Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of growth factors. Experimental evidence…”
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