Search Results - "Desjardins, Christopher A."

Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges by Cohen, Keira A, Manson, Abigail L, Desjardins, Christopher A, Abeel, Thomas, Earl, Ashlee M

“…Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of highly drug-resistant disease. Whole-genome sequencing (WGS)…”
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Ubiquitin-mediated response to microsporidia and virus infection in C. elegans by Bakowski, Malina A, Desjardins, Christopher A, Smelkinson, Margery G, Dunbar, Tiffany L, Dunbar, Tiffany A, Lopez-Moyado, Isaac F, Rifkin, Scott A, Cuomo, Christina A, Troemel, Emily R

“…Microsporidia comprise a phylum of over 1400 species of obligate intracellular pathogens that can infect almost all animals, but little is known about the host…”
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Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators by Hommel, Benjamin, Mukaremera, Liliane, Cordero, Radames J B, Coelho, Carolina, Desjardins, Christopher A, Sturny-Leclère, Aude, Janbon, Guilhem, Perfect, John R, Fraser, James A, Casadevall, Arturo, Cuomo, Christina A, Dromer, Françoise, Nielsen, Kirsten, Alanio, Alexandre

“…The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells…”
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Antagonistic paralogs control a switch between growth and pathogen resistance in C. elegans by Reddy, Kirthi C, Dror, Tal, Underwood, Ryan S, Osman, Guled A, Elder, Corrina R, Desjardins, Christopher A, Cuomo, Christina A, Barkoulas, Michalis, Troemel, Emily R

“…Immune genes are under intense, pathogen-induced pressure, which causes these genes to diversify over evolutionary time and become species-specific. Through a…”
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Advances in Cryptococcus genomics: insights into the evolution of pathogenesis by Cuomo, Christina A, Rhodes, Johanna, Desjardins, Christopher A

“…Cryptococcus species are the causative agents of cryptococcal meningitis, a significant source of mortality in immunocompromised individuals. Initial work on…”
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Genomics of Loa loa, a Wolbachia-free filarial parasite of humans by Desjardins, Christopher A, Cerqueira, Gustavo C, Goldberg, Jonathan M, Hotopp, Julie C Dunning, Haas, Brian J, Zucker, Jeremy, Ribeiro, José M C, Saif, Sakina, Levin, Joshua Z, Fan, Lin, Zeng, Qiandong, Russ, Carsten, Wortman, Jennifer R, Fink, Doran L, Birren, Bruce W, Nutman, Thomas B

“…Thomas Nutman and colleagues report the draft genome of the filarial pathogen Loa loa , the African eyeworm. They also report coverage of two other filarial…”
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Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors by Grant, Sarah Schmidt, Wellington, Samantha, Kawate, Tomohiko, Desjardins, Christopher A, Silvis, Melanie R, Wivagg, Carl, Thompson, Matthew, Gordon, Katherine, Kazyanskaya, Edward, Nietupski, Raymond, Haseley, Nathan, Iwase, Noriaki, Earl, Ashlee M, Fitzgerald, Michael, Hung, Deborah T

“…Successful treatment of Mycobacterium tuberculosis infection typically requires a complex regimen administered over at least 6 months. Interestingly, many of…”
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Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection by Young, Mark G., Straub, Timothy J., Worby, Colin J., Metsky, Hayden C., Gnirke, Andreas, Bronson, Ryan A., van Dijk, Lucas R., Desjardins, Christopher A., Matranga, Christian, Qu, James, Villicana, Jesús Bazan, Azimzadeh, Philippe, Kau, Andrew, Dodson, Karen W., Schreiber, Henry L., Manson, Abigail L., Hultgren, Scott J., Earl, Ashlee M.

“…Low-abundance members of microbial communities are difficult to study in their native habitats, including Escherichia coli , a minor but common inhabitant of…”
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Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii by Farrer, Rhys A, Desjardins, Christopher A, Sakthikumar, Sharadha, Gujja, Sharvari, Saif, Sakina, Zeng, Qiandong, Chen, Yuan, Voelz, Kerstin, Heitman, Joseph, May, Robin C, Fisher, Matthew C, Cuomo, Christina A

“…Cryptococcus gattii is a fungal pathogen of humans, causing pulmonary infections in otherwise healthy hosts. To characterize genomic variation among the four…”
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Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development by Holder, Jason W, Ulrich, Jil C, DeBono, Anthony C, Godfrey, Paul A, Desjardins, Christopher A, Zucker, Jeremy, Zeng, Qiandong, Leach, Alex L B, Ghiviriga, Ion, Dancel, Christine, Abeel, Thomas, Gevers, Dirk, Kodira, Chinnappa D, Desany, Brian, Affourtit, Jason P, Birren, Bruce W, Sinskey, Anthony J

“…The Actinomycetales bacteria Rhodococcus opacus PD630 and Rhodococcus jostii RHA1 bioconvert a diverse range of organic substrates through lipid biosynthesis…”
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Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections by Straub, Timothy J, Chou, Wen-Chi, Manson, Abigail L, Schreiber, 4th, Henry L, Walker, Bruce J, Desjardins, Christopher A, Chapman, Sinéad B, Kaspar, Kerrie L, Kahsai, Orsalem J, Traylor, Elizabeth, Dodson, Karen W, Hullar, Meredith A J, Hultgren, Scott J, Khoo, Christina, Earl, Ashlee M

“…Urinary tract infections (UTIs) affect 15 million women each year in the United States, with > 20% experiencing frequent recurrent UTIs. A recent…”
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Evolutionary dynamics of the accessory genome of Listeria monocytogenes by den Bakker, Henk C, Desjardins, Christopher A, Griggs, Allison D, Peters, Joseph E, Zeng, Qiandong, Young, Sarah K, Kodira, Chinnappa D, Yandava, Chandri, Hepburn, Theresa A, Haas, Brian J, Birren, Bruce W, Wiedmann, Martin

“…Listeria monocytogenes, a foodborne bacterial pathogen, is comprised of four phylogenetic lineages that vary with regard to their serotypes and distribution…”
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Whole Genome Sequencing of Mycobacterium africanum Strains from Mali Provides Insights into the Mechanisms of Geographic Restriction by Winglee, Kathryn, Manson McGuire, Abigail, Maiga, Mamoudou, Abeel, Thomas, Shea, Terrance, Desjardins, Christopher A, Diarra, Bassirou, Baya, Bocar, Sanogo, Moumine, Diallo, Souleymane, Earl, Ashlee M, Bishai, William R

“…Mycobacterium africanum, made up of lineages 5 and 6 within the Mycobacterium tuberculosis complex (MTC), causes up to half of all tuberculosis cases in West…”
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Comparative genomics of vancomycin-resistant Staphylococcus aureus strains and their positions within the clade most commonly associated with Methicillin-resistant S. aureus hospital-acquired infection in the United States by Kos, Veronica N, Desjardins, Christopher A, Griggs, Allison, Cerqueira, Gustavo, Van Tonder, Andries, Holden, Matthew T G, Godfrey, Paul, Palmer, Kelli L, Bodi, Kip, Mongodin, Emmanuel F, Wortman, Jennifer, Feldgarden, Michael, Lawley, Trevor, Gill, Steven R, Haas, Brian J, Birren, Bruce, Gilmore, Michael S

“…Methicillin-resistant Staphylococcus aureus (MRSA) strains are leading causes of hospital-acquired infections in the United States, and clonal cluster 5 (CC5)…”
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Fatal nosocomial MDR TB identified through routine genetic analysis and whole-genome sequencing by Williams, O Martin, Abeel, Thomas, Casali, Nicola, Cohen, Keira, Pym, Alex S, Mungall, Sarah B, Desjardins, Christopher A, Banerjee, Anindo, Drobniewski, Francis, Earl, Ashlee M, Cooke, Graham S

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Recombination and Its Impact on the Genome of the Haplodiploid Parasitoid Wasp Nasonia by Niehuis, Oliver, Gibson, Joshua D, Rosenberg, Michael S, Pannebakker, Bart A, Koevoets, Tosca, Judson, Andrea K, Desjardins, Christopher A, Kennedy, Kathleen, Duggan, David, Beukeboom, Leo W, Zande, Louis van de, Shuker, David M, Werren, John H, Gadau, Jürgen

“…Homologous meiotic recombination occurs in most sexually reproducing organisms, yet its evolutionary advantages are elusive. Previous research explored…”
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Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses by Lockhart, Shawn R., Etienne, Kizee A., Vallabhaneni, Snigdha, Farooqi, Joveria, Chowdhary, Anuradha, Govender, Nelesh P., Colombo, Arnaldo Lopes, Calvo, Belinda, Cuomo, Christina A., Desjardins, Christopher A., Berkow, Elizabeth L., Castanheira, Mariana, Magobo, Rindidzani E., Jabeen, Kauser, Asghar, Rana J., Meis, Jacques F., Jackson, Brendan, Chiller, Tom, Litvintseva, Anastasia P.

“…Background. Candida auris, a multidrug-resistant yeast that causes invasive infections, was first described in 2009 in Japan and has since been reported from…”
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Accelerated microevolution in an outer membrane protein (OMP) of the intracellular bacteria Wolbachia by Baldo, Laura, Desjardins, Christopher A, Russell, Jacob A, Stahlhut, Julie K, Werren, John H

“…Outer membrane proteins (OMPs) of Gram-negative bacteria are key players in the biology of bacterial-host interactions. However, while considerable attention…”
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Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans by Desjardins, Christopher A, Giamberardino, Charles, Sykes, Sean M, Yu, Chen-Hsin, Tenor, Jennifer L, Chen, Yuan, Yang, Timothy, Jones, Alexander M, Sun, Sheng, Haverkamp, Miriam R, Heitman, Joseph, Litvintseva, Anastasia P, Perfect, John R, Cuomo, Christina A

“…is an opportunistic fungal pathogen that causes approximately 625,000 deaths per year from nervous system infections. Here, we leveraged a unique, genetically…”
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Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth by Cuomo, Christina A, Desjardins, Christopher A, Bakowski, Malina A, Goldberg, Jonathan, Ma, Amy T, Becnel, James J, Didier, Elizabeth S, Fan, Lin, Heiman, David I, Levin, Joshua Z, Young, Sarah, Zeng, Qiandong, Troemel, Emily R

“…Microsporidia comprise a large phylum of obligate intracellular eukaryotes that are fungal-related parasites responsible for widespread disease, and here we…”
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