Search Results - "Desi, Ng"

The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium by Desi, Ng, Tay, Yvonne

“…Post-transcriptional regulation plays a key role in modulating gene expression, and the perturbation of transcriptomic equilibrium has been shown to drive the…”
Get full text

MiR-138 is a potent regulator of the heterogenous MYC transcript population in cancers by Desi, Ng, Teh, Velda, Tong, Qing Yun, Lim, Chun You, Tabatabaeian, Hossein, Chew, Xiao Hong, Sanchez-Mejias, Avencia, Chan, Jia Jia, Zhang, Bin, Pitcheshwar, Priyankaa, Siew, Bei-En, Wang, Shi, Lee, Kuok-Chung, Chong, Choon-Seng, Cheong, Wai-Kit, Lieske, Bettina, Tan, Ian Jse-Wei, Tan, Ker-Kan, Tay, Yvonne

“…3′UTR shortening in cancer has been shown to activate oncogenes, partly through the loss of microRNA-mediated repression. This suggests that many reported…”
Get full text

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis by Desi, Ng, Tong, Qing Yun, Teh, Velda, Chan, Jia Jia, Zhang, Bin, Tabatabaeian, Hossein, Tan, Hui Qing, Kapeli, Katannya, Jin, Wenhao, Lim, Chun You, Kwok, Zhi Hao, Tan, Hwee Tong, Wang, Shi, Siew, Bei-En, Lee, Kuok-Chung, Chong, Choon-Seng, Tan, Ker-Kan, Yang, Henry, Kappei, Dennis, Yeo, Gene W., Chung, Maxey Ching Ming, Tay, Yvonne

“…In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding…”
Get full text

Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis by Chan, Jia Jia, Zhang, Bin, Chew, Xiao Hong, Salhi, Adil, Kwok, Zhi Hao, Lim, Chun You, Desi, Ng, Subramaniam, Nagavidya, Siemens, Angela, Kinanti, Tyas, Ong, Shane, Sanchez-Mejias, Avencia, Ly, Phuong Thao, An, Omer, Sundar, Raghav, Fan, Xiaonan, Wang, Shi, Siew, Bei En, Lee, Kuok Chung, Chong, Choon Seng, Lieske, Bettina, Cheong, Wai-Kit, Goh, Yufen, Fam, Wee Nih, Ooi, Melissa G., Koh, Bryan T. H., Iyer, Shridhar Ganpathi, Ling, Wen Huan, Chen, Jianbin, Yoong, Boon-Koon, Chanwat, Rawisak, Bonney, Glenn Kunnath, Goh, Brian K. P., Zhai, Weiwei, Fullwood, Melissa J., Wang, Wilson, Tan, Ker-Kan, Chng, Wee Joo, Dan, Yock Young, Pitt, Jason J., Roca, Xavier, Guccione, Ernesto, Vardy, Leah A., Chen, Leilei, Gao, Xin, Chow, Pierce K. H., Yang, Henry, Tay, Yvonne

“…Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer,…”
Get full text