Search Results - "Deshpande, Shrikant V"

Stimulation of T Cells by Antigenic Peptide Complexed with Isolated Chains of Major Histocompatibility Complex Class II Molecules by Nag, Bishwajit, Wada, H. Garrett, Deshpande, Shrikant V., Passmore, David, Kendrick, Teresa, Sharma, Somesh D., Clark, Brian R., McConnell, Harden M.

“…Major histocompatibility complex (MHC) class II molecules are heterodimeric glycoproteins with one α and one β polypeptide chain of similar molecular size. In…”
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X-ray crystal structure of a macrocyclic copper chelate stable enough for use in living systems: copper(II) dihydrogen 6-(p-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetate by Moi, Min K, Yanuck, Michael, Deshpande, Shrikant V, Hope, Hakon, DeNardo, Sally J, Meares, Claude F

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On the requirement of oxidizing reagent for the formation of a disulfide bond by Berezhkovskiy, Leonid M., Deshpande, Shrikant V.

“…Cyclization of a peptide through the formation of a disulfide bond between the SH groups of cysteines on the N- and C-terminals of peptide was studied in…”
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Yttrium-90-Labeled Monoclonal Antibody for Therapy: Labeling by a New Macrocyclic Bifunctional Chelating Agent by Deshpande, Shrikant V, DeNardo, Sally J, Kukis, David L, Moi, Min K, McCall, Michael J, DeNardo, Gerald L, Meares, Claude F

“…Yttrium-90 (90Y) is a promising radiometal for therapy of cancer due to its high-energy beta emission and a physical half-life of 2.67 days. Bifunctional…”
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Rapid identification of antigenic T-cell epitopes by extracellular acidification rate signals by Arimilli, Subhashini, Howard, Maureen C., Nacy, Carol C., Deshpande, Shrikant V.

“…We used a silicon‐based biosensor, a microphysiometer, to measure real‐time extracellular acidification rate signals associated with T lymphocyte responses to…”
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Identification of core structure and critical T cell receptor contact residues in an antigenic peptide by measuring acidification rates by Arimilli, Subhashini, Deshpande, Shrikant V., Nag, Bishwajit

“…A silicon-based biosensor microphysiometer measures real time cell response by monitoring an increase in extracellular acidification rate in response to…”
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Copper-67-Labeled Monoclonal Antibody Lym-1, a Potential Radiopharmaceutical for Cancer Therapy: Labeling and Biodistribution in RAJI Tumored Mice by Deshpande, Shrikant V, DeNardo, Sally J, Meares, Claude F, McCall, Michael J, Adams, Gregory P, Moi, Min K, DeNardo, Gerald L

“…Copper-67 (67Cu) is one of the most promising radiometals for radioimmunotherapy because of its 61.5 hr physical half-life, abundant beta particles, and gamma…”
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In vitro maximum binding of antigenic peptides to murine MHC class II molecules does not always take place at the acidic pH of the in vivo endosomal compartment by Nag, B, Passmore, D, Deshpande, SV, Clark, BR

“…Presentation of Ag to the T cell requires binding of specific peptide fragments of the Ag to MHC II molecules. The ability of a peptide to bind to MHC class II…”
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Antigenic peptide binding to MHC class II molecules at increased peptide concentrations by Nag, B, Mukku, P V, Arimilli, S, Phan, D, Deshpande, S V, Winkelhake, J L

“…Affinity-purified major histocompatibility complex (MHC) class II molecules are known to bind antigenic peptides in vitro. The percentage of MHC class II…”
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Cloned T cells internalize peptide from bound complexes of peptide and purified class II major histocompatibility complex antigen by NAG, B, DESHPANDE, S. V, SHARMA, S. D, CLARK, B. R

“…Antigen presentation to helper T cells involves the formation of a trimolecular complex consisting of a class II major histocompatibility complex (MHC) antigen…”
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Antigen-specific deletion of cloned T cells using peptide-toxin conjugate complexed with purified class II major histocompatibility complex antigen by Clark, B R, Deshpande, S V, Sharma, S D, Nag, B

“…In a previous report, we showed that cloned T cells incubated with soluble, cognate major histocompatibility complex (MHC) II-peptide complex internalized the…”
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Novel methods to rapidly and sensitively analyze antigenic peptide binding to MHC class II molecules by Nag, B, Deshpande, S V, Clark, B R

“…One of the important steps for antigen presentation by MHC class II molecules involves binding of a peptide fragment of the antigen to the class II molecule…”
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Separation of complexes of major histocompatibility class II molecules and known antigenic peptide by metal chelate affinity chromatography by Nag, B, Mukku, P V, Arimilli, S, Kendrick, T, Deshpande, S V, Sharma, S D

“…A small fraction of affinity-purified MHC class II molecules are known to bind antigenic peptides in vitro. No simple method with acceptable recovery exists…”
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Chelate radiochemistry: cleavable linkers lead to altered levels of radioactivity in the liver by Meares, C F, McCall, M J, Deshpande, S V, DeNardo, S J, Goodwin, D A

“…Bifunctional chelating agents based on benzyl-EDTA bind 111In stably under physiological conditions. Available evidence indicates that the indium is cleared…”
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Effect of different linkages between chelates and monoclonal antibodies on levels of radioactivity in the liver by Deshpande, S V, Denardo, S J, Meares, C F, McCall, M J, Adams, G P, Denardo, G L

“…After injection of radiometal labeled antibodies, the radionuclide accumulates in the liver. This might be altered by a metabolizable linkage between metal…”
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Effect of mass of 111In-benzyl-EDTA monoclonal antibody on hepatic uptake and processing in mice by ADAMS, G. P, DENARDO, S. J, DESHPANDE, S. V, DENARDO, G. L, MEARES, C. F, MCCALL, M. J, EPSTEIN, A. L

“…In patients, the pharmacokinetic behavior of murine monoclonal antibodies has been observed to vary with the amount of antibody administered. It has been…”
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