Search Results - "Deshpande, Prasannakumar"

Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson’s disease by Flinkman, Dani, Hong, Ye, Gnjatovic, Jelena, Deshpande, Prasannakumar, Ortutay, Zsuzsanna, Peltonen, Sirkku, Kaasinen, Valtteri, James, Peter, Coffey, Eleanor

“…Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are synthesis…”
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KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons by Padzik, Artur, Deshpande, Prasannakumar, Hollos, Patrik, Franker, Mariella, Rannikko, Emmy H, Cai, Dawen, Prus, Piotr, Mågård, Mats, Westerlund, Nina, Verhey, Kristen J, James, Peter, Hoogenraad, Casper C, Coffey, Eleanor T

“…Increased phosphorylation of the KIF5 anterograde motor is associated with impaired axonal transport and neurodegeneration, but paradoxically also with normal…”
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JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination by Komulainen, Emilia, Zdrojewska, Justyna, Freemantle, Erika, Mohammad, Hasan, Kulesskaya, Natalia, Deshpande, Prasannakumar, Marchisella, Francesca, Mysore, Raghavendra, Hollos, Patrik, Michelsen, Kimmo A, Mågard, Mats, Rauvala, Heikki, James, Peter, Coffey, Eleanor T

“…Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a…”
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Chondroitin Sulfate‐Coated Heteroduplex‐Molecular Spherical Nucleic Acids by Virta, Pasi, Laine, Toni, Deshpande, Prasannakumar, Tähtinen, Ville, Coffey, Eleanor T.

“…Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial…”
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Protein synthesis is suppressed in sporadic and familial Parkinson’s disease by LRRK2 by Deshpande, Prasannakumar, Flinkman, Dani, Hong, Ye, Goltseva, Elena, Siino, Valentina, Sun, Lihua, Peltonen, Sirkku, Elo, Laura L., Kaasinen, Valtteri, James, Peter, Coffey, Eleanor T.

“…Gain of function LRRK2‐G2019S is the most frequent mutation found in familial and sporadic Parkinson's disease. It is expected therefore that understanding the…”
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Synthesis of Azide-Modified Chondroitin Sulfate Precursors: Substrates for “Click”- Conjugation with Fluorescent Labels and Oligonucleotides by Jadhav, Satish, Gulumkar, Vijay, Deshpande, Prasannakumar, Coffey, Eleanor T, Lönnberg, Harri, Virta, Pasi

“…Azidopropyl-modified precursors of chondroitin sulfate (CS) tetrasaccharides have been synthesized, which, after facile conversion to final CS structures, may…”
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Expanding the Molecular and Clinical Phenotype of Patients With De Novo Variants in KIF5C : A Six Patient Case Series by Gracie, Sara, Deshpande, Prasannakumar, Hollos, Patrik, De Dios, Karl, Martin, Donna M., Pritchard, Amanda B., Scott Schwoerer, Jessica A., Behrmann, Meghan R., Seaver, Laurie H., Brown, Kathleen, Fernandez, Raymond J., Larson, Austin, Coffey, Eleanor

“…ABSTRACT Heterozygous de novo loss of function variants in the motor domain of KIF5C are associated with a neurodevelopmental disorder characterized by…”
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