Search Results - "Deshpande, Ashlesha"

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern by Deshpande, Ashlesha, Harris, Bethany D., Martinez-Sobrido, Luis, Kobie, James J., Walter, Mark R.

“…Severe acute respiratory syndrome coronavirus-2 (SAR-CoV-2) causes coronavirus disease 2019 (COVID19) that is responsible for short and long-term disease, as…”
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Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines by Logsdon, Naomi J, Deshpande, Ashlesha, Harris, Bethany D, Rajashankar, Kanagalaghatta R, Walter, Mark R

“…Interleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces from pathogens. However, dysregulated IL-20 signaling is…”
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Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine by Harris, Bethany D, Kuruganti, Srilalitha, Deshpande, Ashlesha, Goepfert, Paul A, Chatham, W Winn, Walter, Mark R

“…Background/objective Type-I interferons contribute to pathogenesis in systemic lupus erythematosus, including nephritis. Interferons consist of a family of 16…”
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Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody by Piepenbrink, Michael S, Park, Jun-Gyu, Deshpande, Ashlesha, Loos, Andreas, Ye, Chengjin, Basu, Madhubanti, Sarkar, Sanghita, Khalil, Ahmed Magdy, Chauvin, David, Woo, Jennifer, Lovalenti, Philip, Erdmann, Nathaniel B, Goepfert, Paul A, Truong, Vu L, Bowen, Richard A, Walter, Mark R, Martinez-Sobrido, Luis, Kobie, James J

“…Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel β-coronavirus to cause significant human mortality in the last two decades…”
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Vaccination against a Virus-Encoded Cytokine Significantly Restricts Viral Challenge by Eberhardt, Meghan K, Deshpande, Ashlesha, Chang, W L William, Barthold, Stephen W, Walter, Mark R, Barry, Peter A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys by Nelson, Cody S, Cruz, Diana Vera, Tran, Dollnovan, Bialas, Kristy M, Stamper, Lisa, Wu, Huali, Gilbert, Margaret, Blair, Robert, Alvarez, Xavier, Itell, Hannah, Chen, Meng, Deshpande, Ashlesha, Chiuppesi, Flavia, Wussow, Felix, Diamond, Don J, Vandergrift, Nathan, Walter, Mark R, Barry, Peter A, Cohen-Wolkowiez, Michael, Koelle, Katia, Kaur, Amitinder, Permar, Sallie R

“…Human cytomegalovirus (HCMV) is the most common congenital infection and a known cause of microcephaly, sensorineural hearing loss, and cognitive impairment…”
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Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission by Fan, Qihua, Nelson, Cody S, Bialas, Kristy M, Chiuppesi, Flavia, Amos, Joshua, Gurley, Thaddeus C, Marshall, Dawn Jones, Eudailey, Joshua, Heimsath, Holly, Himes, Jonathon, Deshpande, Ashlesha, Walter, Mark R, Wussow, Felix, Diamond, Don J, Barry, Peter A, Moody, M Anthony, Kaur, Amitinder, Permar, Sallie R

“…Human cytomegalovirus (HCMV) is the most common congenital infection worldwide and the leading infectious cause of neurologic deficits and hearing loss in…”
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Kinetic analysis of cytokine‐mediated receptor assembly using engineered FC heterodimers by Deshpande, Ashlesha, Putcha, Balananda‐Dhurjati Kumar, Kuruganti, Srilalitha, Walter, Mark R.

“…A method for analyzing ligand–receptor binding kinetics is described, which is based on an engineered FC domain (FChk) that forms a covalent heterodimer. To…”
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Effect of alcohols on protein hydration: crystallographic analysis of hen egg-white lysozyme in the presence of alcohols by Deshpande, Ashlesha, Nimsadkar, Sagar, Mande, Shekhar C.

“…Organic solvents are known to bring about dehydration of proteins, the molecular basis of which has remained uncharacterized. The dehydration effect in many…”
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Gelatin Blends with Alginate: Gels for Lipase Immobilization and Purification by Fadnavis, Nitin W., Sheelu, Gurrala, Kumar, Bezavada Mani, Bhalerao, Mahendra U., Deshpande, Ashlesha A.

“…Blends of natural polysaccharide sodium alginate (5%) with gelatin (3%) cross‐linked with glutaraldehyde provide beads with excellent compressive strength (8 ×…”
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Structure and epitope of a neutralizing monoclonal antibody that targets the stem helix of β coronaviruses by Deshpande, Ashlesha, Schormann, Nobert, Piepenbrink, Mike S., Martinez Sobrido, Luis, Kobie, James J., Walter, Mark R.

“…Monoclonal antibodies that retain neutralizing activity against multiple coronavirus (CoV) lineages and variants of concern (VoC) must be developed to protect…”
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Functional and Highly Cross-Linkable HIV-1 Envelope Glycoproteins Enriched in a Pretriggered Conformation by Nguyen, Hanh T, Qualizza, Alessandra, Anang, Saumya, Zhao, Meiqing, Zou, Shitao, Zhou, Rong, Wang, Qian, Zhang, Shijian, Deshpande, Ashlesha, Ding, Haitao, Chiu, Ta-Jung, Smith, 3rd, Amos B, Kappes, John C, Sodroski, Joseph G

“…Binding to the receptor, CD4, drives the pretriggered, "closed" (state-1) conformation of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein…”
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Exploitation of Interleukin-10 (IL-10) Signaling Pathways: Alternate Roles of Viral and Cellular IL-10 in Rhesus Cytomegalovirus Infection by Eberhardt, Meghan K, Deshpande, Ashlesha, Fike, Joseph, Short, Rebecca, Schmidt, Kimberli A, Blozis, Shelley A, Walter, Mark R, Barry, Peter A

“…There is accumulating evidence that the viral interleukin-10 (vIL-10) ortholog of both human and rhesus cytomegalovirus (HCMV and RhCMV, respectively)…”
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Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters by Piepenbrink, Michael S., Park, Jun-Gyu, Oladunni, Fatai S., Deshpande, Ashlesha, Basu, Madhubanti, Sarkar, Sanghita, Loos, Andreas, Woo, Jennifer, Lovalenti, Phillip, Sloan, Derek, Ye, Chengjin, Chiem, Kevin, Bates, Christopher W., Burch, Reuben E., Erdmann, Nathaniel B., Goepfert, Paul A., Truong, Vu L., Walter, Mark R., Martinez-Sobrido, Luis, Kobie, James J.

“…SARS-CoV-2 infection results in viral burden in the respiratory tract, enabling transmission and leading to substantial lung pathology. The 1212C2 fully human…”
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Neutralization of rhesus cytomegalovirus IL-10 reduces horizontal transmission and alters long-term immunity by Deere, Jesse D., Chang, W. L. William, Villalobos, Andradi, Schmidt, Kimberli A., Deshpande, Ashlesha, Castillo, Luis D., Fike, Joseph, Walter, Mark R., Barry, Peter A., Hartigan-O’Connor, Dennis J.

“…Human cytomegalovirus (HCMV) causes severe disease in infants and immunocompromised people. There is no approved HCMV vaccine, and vaccine development…”
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Influence of cytokine auto antibodies on serum IFNα activity in SLE (P6287) by Kuruganti, Srilalitha, Deshpande, Ashlesha, Chatham, Winn, Walter, Mark

“…Abstract The type-I interferon (IFN-I) family consists of 12 IFN-α subtypes as well as IFN-β and IFN-ω. IFN-α subtypes are thought to play a pivotal role in…”
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Reverse Micellar Extraction of Antibiotics from Aqueous Solutions by Fadnavis, Nitin W., Satyavathi, B., Deshpande, Ashlesha A.

“…Several antibiotics such as erythromycin, oxytetracyclin, benzylpenicillin, and actidione were extracted from aqueous buffers into reverse micellar solution of…”
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Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain by Yoon, Sung-il, Jones, Brandi C., Logsdon, Naomi J., Harris, Bethany D., Deshpande, Ashlesha, Radaeva, Svetlana, Halloran, Brian A., Gao, Bin, Walter, Mark R.

“…IL-10R2 is a shared cell surface receptor required for the activation of five class 2 cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) that play critical…”
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Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes by Kuruganti, Srilalitha, Miersch, Shane, Deshpande, Ashlesha, Speir, Jeffrey A., Harris, Bethany D., Schriewer, Jill M., Buller, R. Mark L., Sidhu, Sachdev S., Walter, Mark R.

“…Exogenous cytokine therapy can induce systemic toxicity, which might be prevented by activating endogenously produced cytokines in local cell niches. Here we…”
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Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain by Yoon, Sung-il, Jones, Brandi C., Logsdon, Naomi J., Harris, Bethany D., Deshpande, Ashlesha, Radaeva, Svetlana, Halloran, Brian A., Gao, Bin, Walter, Mark R.

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