Search Results - "Deshons, Laurène"

817 DT095895, a selective EP4 receptor antagonist with monotherapy efficacy in syngeneic mouse model(s) and best-in-class properties by Blayo, Anne-Laure, Deshons, Laurène, Dumont, Alexia, Franchet, Christel, Halter, Célia, Herbin, Ludovic, Hommet, Gaël, Mayer, Stanislas, Bessede, Alban, Nafia, Imane, Sidhoum, Marjorie, Leroy, Xavier, Schann, Stéphan

“…BackgroundElevated levels of Prostaglandin E2 (PGE2), an eicosanoid notably synthesized by the cyclooxygenase-2 (COX-2), exert strong immunosuppressive effects…”
Get full text

Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 by Charvin, Delphine, Pomel, Vincent, Ortiz, Millan, Frauli, Mélanie, Scheffler, Sophie, Steinberg, Edith, Baron, Luc, Deshons, Laurène, Rudigier, Rachel, Thiarc, Delphine, Morice, Christophe, Manteau, Baptiste, Mayer, Stanislas, Graham, Danielle, Giethlen, Bruno, Brugger, Nadia, Hédou, Gaël, Conquet, François, Schann, Stephan

“…The metabotropic glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson’s disease (PD). However, since the discovery of its…”
Get full text

Abstract 6697: DT095895, a selective EP4 receptor antagonist with monotherapy efficacy in syngeneic mouse model(s) and best-in-class properties by Blayo, Anne-Laure, Deshons, Laurène, Dumont, Alexia, Franchet, Christel, Halter, Célia, Herbin, Ludovic, Hommet, Gaël, Mayer, Stanislas, Bessede, Alban, Nafia, Imane, Sidhoum, Marjorie, Leroy, Xavier, Schann, Stephan

“…Elevated levels of Prostaglandin E2 (PGE2), an eicosanoid notably synthesized by the cyclooxygenase-2 (COX-2), exert strong immunosuppressive effects in the…”
Get full text