Search Results - "Deshmukh, Gayatri D"

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients by Gajiwala, Ketan S, Wu, Joe C, Christensen, James, Deshmukh, Gayatri D, Diehl, Wade, DiNitto, Jonathan P, English, Jessie M, Greig, Michael J, He, You-Ai, Jacques, Suzanne L, Lunney, Elizabeth A, McTigue, Michele, Molina, David, Quenzer, Terri, Wells, Peter A, Yu, Xiu, Zhang, Yan, Zou, Aihua, Emmett, Mark R, Marshall, Alan G, Zhang, Hui-Min, Demetri, George D

“…Most gastrointestinal stromal tumors (GISTs) exhibit aberrant activation of the receptor tyrosine kinase (RTK) KIT. The efficacy of the inhibitors imatinib…”
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Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance by DiNitto, Jonathan P, Deshmukh, Gayatri D, Zhang, Yan, Jacques, Suzanne L, Coli, Rocco, Worrall, Joseph W, Diehl, Wade, English, Jessie M, Wu, Joe C

“…The activation of receptor tyrosine kinases (RTKs) is tightly regulated through a variety of mechanisms. Kinetic studies show that activation of c-Kit RTK…”
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Enhanced selectivity profile of pyrazole-urea based DFG-out p38α inhibitors by Liu, Hu, Kuhn, Cyrille, Feru, Frederic, Jacques, Suzanne L., Deshmukh, Gayatri D., Ye, Ping, Rennie, Glen R., Johnson, Theresa, Kazmirski, Steven, Low, Simon, Coli, Rocco, Ding, Yuan-hua, Cheng, Alan C., Tecle, Haile, English, Jessie M., Stanton, Robert, Wu, Joe C.

“…The development of potent and selective p38 inhibitor 11 is reported. By targeting an extended region of the conventional ‘DFG-out’ pocket of p38α, while…”
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Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38α for High Throughput Screening Binding Assay by Tecle, Haile, Feru, Frederic, Liu, Hu, Kuhn, Cyrille, Rennie, Glen, Morris, Mark, Shao, Jiangxing, Cheng, Alan C, Gikunju, Diana, Miret, Juan, Coli, Rocco, Xi, Simon (Hualin), Clugston, Susan L, Low, Simon, Kazmirski, Steven, Ding, Yuan-Hua, Cao, Qing, Johnson, Theresa L, Deshmukh, Gayatri D, DiNitto, Jonathan P, Wu, Joe C, English, Jessie M

“…The design, synthesis and utility of fluorescence probes that bind to the DFG-out conformation of p38α kinase are described. Probes that demonstrate good…”
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Failure of L-carnitine to protect mice against hyperammonemia induced by ammonium acetate or urease injection by Deshmukh, D R, Singh, K R, Meert, K, Deshmukh, G D

“…Reports indicate that L-carnitine administration before 100% lethal dose of ammonium acetate suppresses the symptoms of ammonia toxicity and prevents death in…”
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Enhanced selectivity profile of pyrazole-urea based DFG-out p38a inhibitors by Liu, Hu, Kuhn, Cyrille, Feru, Frederic, Jacques, Suzanne L, Deshmukh, Gayatri D, Ye, Ping, Rennie, Glen R, Johnson, Theresa, Kazmirski, Steven, Low, Simon, Coli, Rocco, Ding, Yuan-Hua, Cheng, Alan C, Tecle, Haile, English, Jessie M, Stanton, Robert, Wu, Joe C

“…By targeting an extended region of the conventional 'DFG-out' pocket of p38a, while minimizing interactions with the specificity pocket and eliminating…”
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Enhanced selectivity profile of pyrazole-urea based DFG-out p38alpha inhibitors by Liu, Hu, Kuhn, Cyrille, Feru, Frederic, Jacques, Suzanne L, Deshmukh, Gayatri D, Ye, Ping, Rennie, Glen R, Johnson, Theresa, Kazmirski, Steven, Low, Simon, Coli, Rocco, Ding, Yuan-hua, Cheng, Alan C, Tecle, Haile, English, Jessie M, Stanton, Robert, Wu, Joe C

“…By targeting an extended region of the conventional 'DFG-out' pocket of p38alpha, while minimizing interactions with the specificity pocket and eliminating…”
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The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay by Tecle, Haile, Feru, Frederic, Liu, Hu, Kuhn, Cyrille, Rennie, Glen, Morris, Mark, Shao, Jiangxing, Cheng, Alan C, Gikunju, Diana, Miret, Juan, Coli, Rocco, Xi, Simon Hualin, Clugston, Susan L, Low, Simon, Kazmirski, Steven, Ding, Yuan-Hua, Cao, Qing, Johnson, Theresa L, Deshmukh, Gayatri D, DiNitto, Jonathan P, Wu, Joe C, English, Jessie M

“…The design, synthesis and utility of fluorescence probes that bind to the DFG-out conformation of p38alpha kinase are described. Probes that demonstrate good…”
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A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus by ZADOR, I. Z, DESHMUKH, G. D, KUNKEL, R, JOHNSON, K, RADIN, N. S, SHAYMAN, J. A

“…Glucosylceramide (GlcCer) and related glycosphingolipids have been implicated as causal elements in both the growth of cells and in the regulation of hormonal…”
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Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol by Shayman, J A, Deshmukh, G D, Mahdiyoun, S, Thomas, T P, Wu, D, Barcelon, F S, Radin, N S

“…Two independent approaches were employed to explore the potential role of endogenous glucosylceramide or a closely related glucosphingolipid in mediating the…”
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The carbohydrate composition of mucin in colonic cancer by Boland, C R, Deshmukh, G D

“…Mucins synthesized in colonic cancer are known to be different from those in the normal colon; however, the biochemical differences between these mucins have…”
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Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of beta-glucosidase inhibition by Mahdiyoun, S, Deshmukh, G D, Abe, A, Radin, N S, Shayman, J A

“…Recent work has demonstrated the enhancement of hormone-stimulated inositol trisphosphate formation in renal epithelial cells under conditions of…”
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Analysis of cancer-associated colonic mucin by ion-exchange chromatography: evidence for a mucin species of lower molecular charge and weight in cancer by Shimamoto, C, Deshmukh, G D, Rigot, W L, Boland, C R

“…Cancer-associated mucins in the colon are antigenically distinct and glycosylated differently from their normal counterparts. Mucin-rich glycoconjugate…”
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Formation of free fatty acid and ceramide during brain handling: lability of sphingomyelin by Deshmukh, G D, Radin, N S

“…Intact brain and brain homogenates readily form free fatty acids and ceramides, even in the cold during subcellular isolation procedures. The fatty acid…”
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Determination of glucocerebroside, sphingomyelin, free fatty acid and total lipid by thin-layer chromatography and charring-scintillation quenching by Radin, N S, Deshmukh, G D, Selvam, R, Hospattankar, A V

“…A previously described method has been extended to various specific lipids of liver and brain. The basic method involves thin-layer chromatography followed by…”
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Free fatty acids in an animal model of Reye's syndrome by Deshmukh, D R, Deshmukh, G D, Shope, T C, Radin, N S

“…Recent studies have indicated that viral infections, aspirin treatment and hyperammonemia are associated with Reye's syndrome. It has also been reported that…”
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