Search Results - "Deshayes, Sebastien"

Cell-penetrating peptides: from molecular mechanisms to therapeutics by Morris, May C., Deshayes, Sebastien, Heitz, Frederic, Divita, Gilles

“…The recent discovery of new potent therapeutic molecules which do not reach the clinic due to poor delivery and low bioavailability have made the delivery of…”
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Everything you always wanted to know about CADY-mediated siRNA delivery ( but afraid to ask) by Konate, Karidia, Rydstrom, Anna, Divita, Gilles, Deshayes, Sebastien

“…Although siRNA consist in very promising therapeutics, their clinical development is limited by several biological barriers including low cellular…”
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Fluorescence Technologies for Monitoring Interactions Between Biological Molecules In Vitro by Deshayes, Sebastien, Divita, Gilles

“…Over the last two centuries, the discovery and understanding of the principle of fluorescence have provided new means of characterizing…”
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Secondary structure of cell-penetrating peptides controls membrane interaction and insertion by Eiríksdóttir, Emelía, Konate, Karidia, Langel, Ülo, Divita, Gilles, Deshayes, Sébastien

“…The clinical use of efficient therapeutic agents is often limited by the poor permeability of the biological membranes. In order to enhance their cell…”
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Delivery of therapeutic oligonucleotides with cell penetrating peptides by Boisguérin, Prisca, Deshayes, Sébastien, Gait, Michael J., O'Donovan, Liz, Godfrey, Caroline, Betts, Corinne A., Wood, Matthew J.A., Lebleu, Bernard

“…Oligonucleotide-based drugs have received considerable attention for their capacity to modulate gene expression very specifically and as a consequence they…”
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Peptide-Based Nanoparticles to Rapidly and Efficiently “Wrap ’n Roll” siRNA into Cells by Konate, Karidia, Dussot, Marion, Aldrian, Gudrun, Vaissière, Anaïs, Viguier, Véronique, Neira, Isabel Ferreiro, Couillaud, Franck, Vivès, Eric, Boisguerin, Prisca, Deshayes, Sébastien

“…Delivery of small interfering RNA (siRNA) as a therapeutic tool is limited due to critical obstacles such as the cellular barrier, the negative charges of the…”
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Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy by Deshayes, Sébastien, Morris, May, Heitz, Frédéric, Divita, Gilles

“…The recent discovery of new potent therapeutic molecules which do not reach the clinic due to poor delivery and low bioavailability have made of delivery a key…”
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How to evaluate the cellular uptake of CPPs with fluorescence techniques: Dissecting methodological pitfalls associated to tryptophan-rich peptides by Seisel, Quentin, Pelletier, François, Deshayes, Sébastien, Boisguerin, Prisca

“…Cell-penetrating peptides (CPP) are broadly recognized as efficient non-viral vectors for the internalization of compounds such as peptides, oligonucleotides…”
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Deciphering the internalization mechanism of WRAP:siRNA nanoparticles by Deshayes, Sébastien, Konate, Karidia, Dussot, Marion, Chavey, Bérengère, Vaissière, Anaïs, Van, Thi Nhu Ngoc, Aldrian, Gudrun, Padari, Kärt, Pooga, Margus, Vivès, Eric, Boisguérin, Prisca

“…Gene silencing mediated by double-stranded small interfering RNA (siRNA) has been widely investigated as a potential therapeutic approach for a variety of…”
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Peptide-Based Nanoparticles for Therapeutic Nucleic Acid Delivery by Boisguérin, Prisca, Konate, Karidia, Josse, Emilie, Vivès, Eric, Deshayes, Sébastien

“…Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the immune system to fight against disease by delivering…”
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LIX1 Controls MAPK Signaling Reactivation and Contributes to GIST-T1 Cell Resistance to Imatinib by Ruiz-Demoulin, Salomé, Trenquier, Eva, Dekkar, Sanaa, Deshayes, Sébastien, Boisguérin, Prisca, Serrano, César, de Santa Barbara, Pascal, Faure, Sandrine

“…Gastrointestinal stromal tumor (GIST), the most common sarcoma, is mainly caused by an oncogenic mutation in the KIT receptor tyrosine kinase. Targeting KIT…”
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A retro-inverso cell-penetrating peptide for siRNA delivery by Vaissière, Anaïs, Aldrian, Gudrun, Konate, Karidia, Lindberg, Mattias F, Jourdan, Carole, Telmar, Anthony, Seisel, Quentin, Fernandez, Frédéric, Viguier, Véronique, Genevois, Coralie, Couillaud, Franck, Boisguerin, Prisca, Deshayes, Sébastien

“…Small interfering RNAs (siRNAs) are powerful tools to control gene expression. However, due to their poor cellular permeability and stability, their…”
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Direct translocation as major cellular uptake for CADY self-assembling peptide-based nanoparticles by Rydström, Anna, Deshayes, Sébastien, Konate, Karidia, Crombez, Laurence, Padari, Kärt, Boukhaddaoui, Hassan, Aldrian, Gudrun, Pooga, Margus, Divita, Gilles

“…Cell penetrating peptides constitute a potent approach to overcome the limitations of in vivo siRNA delivery. We recently proposed a peptide-based nanoparticle…”
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WRAP-based nanoparticles for siRNA delivery: a SAR study and a comparison with lipid-based transfection reagents by Konate, Karidia, Josse, Emilie, Tasic, Milana, Redjatti, Karima, Aldrian, Gudrun, Deshayes, Sébastien, Boisguérin, Prisca, Vivès, Eric

“…Recently, we designed novel amphipathic cell-penetrating peptides, called WRAP, able to transfer efficiently siRNA molecules into cells. In order to gain more…”
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Structural polymorphism of non-covalent peptide-based delivery systems: Highway to cellular uptake by Deshayes, Sébastien, Konate, Karidia, Aldrian, Gudrun, Crombez, Laurence, Heitz, Frédéric, Divita, Gilles

“…During the last two decades, delivery has become a major challenge for the development of new therapeutic molecules for the clinic. Although, several…”
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Optimisation of vectorisation property: A comparative study for a secondary amphipathic peptide by Konate, Karidia, Lindberg, Mattias F., Vaissiere, Anaïs, Jourdan, Carole, Aldrian, Gudrun, Margeat, Emmanuel, Deshayes, Sébastien, Boisguerin, Prisca

“…[Display omitted] RNA interference provides a powerful technology for specific gene silencing. Therapeutic applications of small interfering RNA (siRNA)…”
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Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide by Konate, Karidia, Seisel, Quentin, Vivès, Eric, Boisguérin, Prisca, Deshayes, Sébastien

“…Cell-penetrating peptides (CPPs) are defined as carriers that are able to cross the plasma membrane and to transfer a cargo into cells. One of the main common…”
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Insight into the Cellular Uptake Mechanism of a Secondary Amphipathic Cell-Penetrating Peptide for siRNA Delivery by Konate, Karidia, Crombez, Laurence, Deshayes, Sébastien, Decaffmeyer, Marc, Thomas, Annick, Brasseur, Robert, Aldrian, Gudrun, Heitz, Frederic, Divita, Gilles

“…Delivery of siRNA remains a major limitation to their clinical application, and several technologies have been proposed to improve their cellular uptake. We…”
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PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo by Aldrian, Gudrun, Vaissière, Anaïs, Konate, Karidia, Seisel, Quentin, Vivès, Eric, Fernandez, Frédéric, Viguier, Véronique, Genevois, Coralie, Couillaud, Franck, Démèné, Héléne, Aggad, Dina, Covinhes, Aurélie, Barrère-Lemaire, Stéphanie, Deshayes, Sébastien, Boisguerin, Prisca

“…Small interfering RNAs (siRNAs) present a strong therapeutic potential because of their ability to inhibit the expression of any desired protein. Recently, we…”
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In Vivo Follow-Up of Gene Inhibition in Solid Tumors Using Peptide-Based Nanoparticles for siRNA Delivery by Ferreiro, Isabel, Genevois, Coralie, Konate, Karidia, Vivès, Eric, Boisguérin, Prisca, Deshayes, Sébastien, Couillaud, Franck

“…Small interfering RNA (siRNA) exhibits a high degree of specificity for targeting selected genes. They are efficient on cells in vitro, but in vivo siRNA…”
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