Search Results - "Desforges, Marc"

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? by Desforges, Marc, Le Coupanec, Alain, Dubeau, Philippe, Bourgouin, Andréanne, Lajoie, Louise, Dubé, Mathieu, Talbot, Pierre J

“…Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the…”
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Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43 by Dubé, Mathieu, Le Coupanec, Alain, Wong, Alan H M, Rini, James M, Desforges, Marc, Talbot, Pierre J

“…Human coronaviruses (HCoVs) are recognized respiratory pathogens for which accumulating evidence indicates that in vulnerable patients the infection can cause…”
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Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis by Desforges, Marc, Le Coupanec, Alain, Stodola, Jenny K., Meessen-Pinard, Mathieu, Talbot, Pierre J.

“…•Human coronavirus (HCoV) are naturally neuroinvasive in both mice and humans.•Both transneuronal and hematogenous route may allow virus invasion of the…”
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Pivotal Role of Receptor-Interacting Protein Kinase 1 and Mixed Lineage Kinase Domain-Like in Neuronal Cell Death Induced by the Human Neuroinvasive Coronavirus OC43 by Meessen-Pinard, Mathieu, Le Coupanec, Alain, Desforges, Marc, Talbot, Pierre J

“…Human coronaviruses (HCoV) are respiratory pathogens with neuroinvasive, neurotropic, and neurovirulent properties, highlighting the importance of studying the…”
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The human coronavirus HCoV-229E S-protein structure and receptor binding by Li, Zhijie, Tomlinson, Aidan Ca, Wong, Alan Hm, Zhou, Dongxia, Desforges, Marc, Talbot, Pierre J, Benlekbir, Samir, Rubinstein, John L, Rini, James M

“…The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows…”
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The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology by Stodola, Jenny K., Dubois, Guillaume, Le Coupanec, Alain, Desforges, Marc, Talbot, Pierre J.

“…The OC43 strain of human coronavirus (HCoV-OC43) is an ubiquitous respiratory tract pathogen possessing neurotropic capacities. Coronavirus structural envelope…”
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Receptor-binding loops in alphacoronavirus adaptation and evolution by Wong, Alan H. M., Tomlinson, Aidan C. A., Zhou, Dongxia, Satkunarajah, Malathy, Chen, Kevin, Sharon, Chetna, Desforges, Marc, Talbot, Pierre J., Rini, James M.

“…RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral…”
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Novel Treatment with Neuroprotective and Antiviral Properties against a Neuroinvasive Human Respiratory Virus by Brison, Elodie, Jacomy, Hélène, Desforges, Marc, Talbot, Pierre J

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Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike by Prévost, Jérémie, Gasser, Romain, Beaudoin-Bussières, Guillaume, Richard, Jonathan, Duerr, Ralf, Laumaea, Annemarie, Anand, Sai Priya, Goyette, Guillaume, Benlarbi, Mehdi, Ding, Shilei, Medjahed, Halima, Lewin, Antoine, Perreault, Josée, Tremblay, Tony, Gendron-Lepage, Gabrielle, Gauthier, Nicolas, Carrier, Marc, Marcoux, Diane, Piché, Alain, Lavoie, Myriam, Benoit, Alexandre, Loungnarath, Vilayvong, Brochu, Gino, Haddad, Elie, Stacey, Hannah D., Miller, Matthew S., Desforges, Marc, Talbot, Pierre J., Maule, Graham T. Gould, Côté, Marceline, Therrien, Christian, Serhir, Bouchra, Bazin, Renée, Roger, Michel, Finzi, Andrés

“…SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The…”
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The Acetyl-Esterase Activity of the Hemagglutinin-Esterase Protein of Human Coronavirus OC43 Strongly Enhances the Production of Infectious Virus by Desforges, Marc, Desjardins, Jessica, Zhang, Chengsheng, Talbot, Pierre J

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Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System by Le Coupanec, Alain, Desforges, Marc, Meessen-Pinard, Mathieu, Dubé, Mathieu, Day, Robert, Seidah, Nabil G, Talbot, Pierre J

“…Human coronaviruses (HCoV) are respiratory pathogens that may be associated with the development of neurological diseases, in view of their neuroinvasive and…”
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Human Coronavirus-Induced Neuronal Programmed Cell Death Is Cyclophilin D Dependent and Potentially Caspase Dispensable by Favreau, Dominique J, Meessen-Pinard, Mathieu, Desforges, Marc, Talbot, Pierre J

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Glutamate Excitotoxicity Is Involved in the Induction of Paralysis in Mice after Infection by a Human Coronavirus with a Single Point Mutation in Its Spike Protein by BRISON, Elodie, JACOMY, Hélène, DESFORGES, Marc, TALBOT, Pierre J

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Uncertainty around the Long-Term Implications of COVID-19 by Desforges, Marc, Gurdasani, Deepti, Hamdy, Adam, Leonardi, Anthony J

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 231 million people globally, with more than 4.7 million deaths recorded by…”
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Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication by CENCIC, Regina, DESFORGES, Marc, PELLETIER, Jerry, HALL, David R, KOZAKOV, Dima, YUHONG DU, MIN, Jaeki, DINGLEDINE, Raymond, HAIAN FU, VAJDA, Sandor, TALBOT, Pierre J

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Natural spring water gargle samples as an alternative to nasopharyngeal swabs for SARS‐CoV‐2 detection using a laboratory‐developed test by Gobeille Paré, Sarah, Bestman‐Smith, Julie, Fafard, Judith, Doualla‐Bell, Florence, Jacob‐Wagner, Mariève, Lavallée, Christian, Charest, Hugues, Beauchemin, Stéphanie, Coutlée, François, Dumaresq, Jeannot, Busque, Lambert, St‐Hilaire, Manon, Lépine, Guylaine, Boucher, Valérie, Desforges, Marc, Goupil‐Sormany, Isabelle, Labbé, Annie‐Claude

“…The objective of this study was to validate the use of spring water gargle (SWG) as an alternative to oral and nasopharyngeal swab (ONPS) for SARS‐CoV‐2…”
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Human Respiratory Coronavirus OC43: Genetic Stability and Neuroinvasion by ST-JEAN, Julien R, JACOMY, Hélène, DESFORGES, Marc, VABRET, Astrid, FREYMUTH, Francois, TALBOT, Pierre J

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Recovery of a Neurovirulent Human Coronavirus OC43 from an Infectious cDNA Clone by ST-JEAN, Julien R, DESFORGES, Marc, ALMAZAN, Fernando, JACOMY, Hélène, ENJUANES, Luis, TALBOT, Pierre J

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Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans by Desforges, Marc, Le Coupanec, Alain, Brison, Elodie, Meessen-Pinard, Mathieu, Talbot, Pierre J

“…In humans, viral infections of the respiratory tract are a leading cause of morbidity and mortality worldwide. Several recognized respiratory viral agents have…”
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Human Coronavirus OC43 Associated with Fatal Encephalitis by Morfopoulou, Sofia, Brown, Julianne R, Davies, E. Graham, Anderson, Glenn, Virasami, Alex, Qasim, Waseem, Chong, Wui K, Hubank, Michael, Plagnol, Vincent, Desforges, Marc, Jacques, Thomas S, Talbot, Pierre J, Breuer, Judith

“…In this case report, severe encephalitis with no established cause developed in a child with SCID. Through deep sequencing, human coronavirus OC43 was…”
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