Search Results - "Desdoits‐Lethimonier, Christèle"

Six Decades of Research on Human Fetal Gonadal Steroids by Connan-Perrot, Stéphane, Léger, Thibaut, Lelandais, Pauline, Desdoits-Lethimonier, Christèle, David, Arthur, Fowler, Paul A., Mazaud-Guittot, Séverine

“…Human fetal gonads acquire endocrine steroidogenic capabilities early during their differentiation. Genetic studies show that this endocrine function plays a…”
Get full text

Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis by Leverrier‐Penna, Sabrina, Michel, Alain, Lecante, Laetitia L., Costet, Nathalie, Suglia, Antonio, Desdoits‐Lethimonier, Christèle, Boulay, Hugoline, Viel, Roselyne, Chemouny, Jonathan M., Becker, Emmanuelle, Lavoué, Vincent, Rolland, Antoine D., Dejucq‐Rainsford, Nathalie, Vigneau, Cécile, Mazaud‐Guittot, Séverine

“…Acetaminophen, aspirin, and ibuprofen are mild analgesics commonly used by pregnant women, the sole current recommendation being to avoid ibuprofen from the…”
Get full text

An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes by Ben Maamar, Millissia, Lesné, Laurianne, Desdoits-Lethimonier, Christèle, Coiffec, Isabelle, Lassurguère, Julie, Lavoué, Vincent, Deceuninck, Yoann, Antignac, Jean-Philippe, Le Bizec, Bruno, Perdu, Elisabeth, Zalko, Daniel, Pineau, Charles, Chevrier, Cécile, Dejucq-Rainsford, Nathalie, Mazaud-Guittot, Séverine, Jégou, Bernard

“…Few studies have been undertaken to assess the possible effects of bisphenol A (BPA) on the reproductive hormone balance in animals or humans with often…”
Get full text

Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders by Sèdes, Lauriane, Desdoits-Lethimonier, Christèle, Rouaisnel, Betty, Holota, Hélène, Thirouard, Laura, Lesne, Laurianne, Damon-Soubeyrand, Christelle, Martinot, Emmanuelle, Saru, Jean-Paul, Mazaud-Guittot, Séverine, Caira, Françoise, Beaudoin, Claude, Jégou, Bernard, Volle, David H.

“…Several studies have reported an association between the farnesoid X receptor alpha (FXRα) and estrogenic signaling pathways. Fxrα could thus be involved in…”
Get full text

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism by Kristensen, David Møbjerg, Desdoits-Lethimonier, Christèle, Mackey, Abigail L., Dalgaard, Marlene Danner, De Masi, Federico, Munkbøl, Cecilie Hurup, Styrishave, Bjarne, Antignac, Jean-Philippe, Le Bizec, Bruno, Platel, Christian, Hay-Schmidt, Anders, Jensen, Tina Kold, Lesné, Laurianne, Mazaud-Guittot, Séverine, Kristiansen, Karsten, Brunak, Søren, Kjaer, Michael, Juul, Anders, Jégou, Bernard

“…Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a…”
Get full text

Paracetamol, Aspirin, and Indomethacin Induce Endocrine Disturbances in the Human Fetal Testis Capable of Interfering With Testicular Descent by Mazaud-Guittot, Séverine, Nicolaz, Christophe Nicolas, Desdoits-Lethimonier, Christèle, Coiffec, Isabelle, Maamar, Millissia Ben, Balaguer, Patrick, Kristensen, David M, Chevrier, Cécile, Lavoué, Vincent, Poulain, Patrice, Dejucq-Rainsford, Nathalie, Jégou, Bernard

“…Context: Masculinization depends on the fetal testis. Exposure of the human fetus during pregnancy to paracetamol and/or to other mild analgesics is associated…”
Get full text

Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model by Lecante, Laetitia L, Leverrier-Penna, Sabrina, Gicquel, Thomas, Giton, Frank, Costet, Nathalie, Desdoits-Lethimonier, Christèle, Lesné, Laurianne, Fromenty, Bernard, Lavoué, Vincent, Rolland, Antoine D, Mazaud-Guittot, Séverine

“…Acetaminophen (APAP, paracetamol) is widely used by pregnant women. Although long considered safe, growing evidence indicates that APAP is an endocrine…”
Get full text

Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo by Lesné, Laurianne, Desdoits-Lethimonier, Christèle, Hug, Elisa, Costet, Nathalie, Raffenne, Léo, Toupin, Maryne, Evrard, Bertrand, Kugathas, Indusha, Lavoué, Vincent, Chalmel, Frédéric, Jégou, Bernard, Mazaud-Guittot, Séverine

“…Abstract Valproic acid (VPA) has long been the most widely used antiepileptic drug (AED) for the treatment of epilepsy, bipolar psychiatric disorders, and…”
Get full text

Ibuprofen results in alterations of human fetal testis development by Ben Maamar, Millissia, Lesné, Laurianne, Hennig, Kristin, Desdoits-Lethimonier, Christèle, Kilcoyne, Karen R., Coiffec, Isabelle, Rolland, Antoine D., Chevrier, Cécile, Kristensen, David M., Lavoué, Vincent, Antignac, Jean-Philippe, Le Bizec, Bruno, Dejucq-Rainsford, Nathalie, Mitchell, Rod T., Mazaud-Guittot, Séverine, Jégou, Bernard

“…Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown…”
Get full text

The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial by Coumoul, Xavier, Servien, Rémi, Juricek, Ludmila, Kaddouch-Amar, Yael, Lippi, Yannick, Berthelot, Laureline, Naylies, Claire, Morvan, Marie-Line, Antignac, Jean-Philippe, Desdoits-Lethimonier, Christèle, Jegou, Bernard, Tremblay-Franco, Marie, Canlet, Cécile, Debrauwer, Laurent, Le Gall, Caroline, Laurent, Julie, Gouraud, Pierre-Antoine, Cravedi, Jean-Pierre, Jeunesse, Elisabeth, Savy, Nicolas, Dandere-Abdoulkarim, Kadidiatou, Arnich, Nathalie, Fourès, Franck, Cotton, Jérome, Broudin, Simon, Corman, Bruno, Moing, Annick, Laporte, Bérengère, Richard-Forget, Florence, Barouki, Robert, Rogowsky, Peter, Salles, Bernard

“…Abstract The GMO90+ project was designed to identify biomarkers of exposure or health effects in Wistar Han RCC rats exposed in their diet to 2 genetically…”
Get full text

Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling by Callier, Patrick, Calvel, Pierre, Matevossian, Armine, Makrythanasis, Periklis, Bernard, Pascal, Kurosaka, Hiroshi, Vannier, Anne, Thauvin-Robinet, Christel, Borel, Christelle, Mazaud-Guittot, Séverine, Rolland, Antoine, Desdoits-Lethimonier, Christèle, Guipponi, Michel, Zimmermann, Céline, Stévant, Isabelle, Kuhne, Françoise, Conne, Béatrice, Santoni, Federico, Lambert, Sandy, Huet, Frederic, Mugneret, Francine, Jaruzelska, Jadwiga, Faivre, Laurence, Wilhelm, Dagmar, Jégou, Bernard, Trainor, Paul A, Resh, Marilyn D, Antonarakis, Stylianos E, Nef, Serge

“…The Hedgehog (Hh) family of secreted proteins act as morphogens to control embryonic patterning and development in a variety of organ systems…”
Get full text

Many Putative Endocrine Disruptors Inhibit Prostaglandin Synthesis by Kristensen, David M., Skalkam, Maria L., Audouze, Karine, Lesné, Laurianne, Desdoits-Lethimonier, Christele, Frederiksen, Hanne, Brunak, Søren, Skakkebæk, Niels E., Jégou, Bernard, Hansen, Jacob B., Junker, Steffen, Leffers, Henrik

“…Background: Prostaglandins (PGs) play key roles in development and maintenance of homeostasis of the adult body. Despite these important roles, it remains…”
Get full text

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis by Desdoits-Lethimonier, C., Lesné, L., Gaudriault, P., Zalko, D., Antignac, J.P., Deceuninck, Y., Platel, C., Dejucq-Rainsford, N., Mazaud-Guittot, S., Jégou, B.

“…Abstract STUDY QUESTION Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? SUMMARY ANSWER The endocrine function of human…”
Get full text

Loss of Function Mutation in the Palmitoyl-Transferase HHAT Leads to Syndromic 46,XY Disorder of Sex Development by Impeding Hedgehog Protein Palmitoylation and Signaling: e1004340 by Callier, Patrick, Calvel, Pierre, Matevossian, Armine, Makrythanasis, Periklis, Bernard, Pascal, Kurosaka, Hiroshi, Vannier, Anne, Thauvin-Robinet, Christel, Borel, Christelle, Mazaud-Guittot, Séverine, Rolland, Antoine, Desdoits-Lethimonier, Christèle, Guipponi, Michel, Zimmermann, Céline, Stévant, Isabelle, Kuhne, Françoise, Conne, Béatrice, Santoni, Federico, Lambert, Sandy, Huet, Frederic, Mugneret, Francine, Jaruzelska, Jadwiga, Faivre, Laurence, Wilhelm, Dagmar, Jégou, Bernard, Trainor, Paul A, Resh, Marilyn D, Antonarakis, Stylianos E, Nef, Serge

“…The Hedgehog (Hh) family of secreted proteins act as morphogens to control embryonic patterning and development in a variety of organ systems…”
Get full text

Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro by Albert, O., Desdoits-Lethimonier, C., Lesné, L., Legrand, A., Guillé, F., Bensalah, K., Dejucq-Rainsford, N., Jégou, B.

“…STUDY QUESTION Do mild analgesics affect the endocrine system of the human adult testis? SUMMARY ANSWER Mild analgesics induce multiple endocrine disturbances…”
Get full text

Human testis steroidogenesis is inhibited by phthalates by Desdoits-Lethimonier, C., Albert, O., Le Bizec, B., Perdu, E., Zalko, D., Courant, F., Lesné, L., Guillé, F., Dejucq-Rainsford, N., Jégou, B.

“…BACKGROUND Phthalic acid esters are widely used in the manufacture of plastics. Numerous studies have shown that these phthalates impair testicular…”
Get full text

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat by Kristensen, David Møbjerg, Hass, Ulla, Lesné, Laurianne, Lottrup, Grete, Jacobsen, Pernille Rosenskjold, Desdoits-Lethimonier, Christele, Boberg, Julie, Petersen, Jørgen Holm, Toppari, Jorma, Jensen, Tina Kold, Brunak, Søren, Skakkebæk, Niels E., Nellemann, Christine, Main, Katharina M., Jégou, Bernard, Leffers, Henrik

“…BACKGROUND More than half of pregnant women in the Western world report intake of mild analgesics, and some of these drugs have been associated with…”
Get full text

Evaluation of the impact of cannabinoids used for recreational or therapeutic purposes on the male germ cell differentiation during development by Dochez-Arnault, J., da Silva, J., Desdoits-Lethimoniers, C., Kernanec, P.-Y., Mazaud-Guittot, S., Dejucq-Rainsford, N., Gely-Pernot, A.

“…impact of cannabinoids used for recreational or therapeutic purposes on the male germ cell differentiation during development…”
Get full text

Characterization of the effects of the steroidogenesis inhibitor Ketoconazole on the human fetal ovary by Lelandais, P., Lecante, L.L., Desdoits-Lethimonier, C., Connan-Perrot, S., Toupin, M., Filis, P., Lavoué, V., A, P.A., Mazaud-Guittot, S.

Get full text

Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis by Kristensen, D. M., Lesné, L., Le Fol, V., Desdoits-Lethimonier, C., Dejucq-Rainsford, N., Leffers, H., Jégou, B.

“…Summary More than half the pregnant women in the Western world report taking mild analgesics. These pharmaceutical compounds have been associated with…”
Get full text