Search Results - "Desaulniers, Jean"

Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid-siRNA conjugates by Salim, Lidya, Islam, Golam, Desaulniers, Jean-Paul

“…One of the major hurdles in RNAi research has been the development of safe and effective delivery systems for siRNAs. Although various chemical modifications…”
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Direct Conjugation of Gallium‐(III)‐Corroles to Short Interfering RNA(siRNA) Providing Real‐Time siRNA Imaging and Gene Silencing by Giorgees, Ifrodet, Affe, Vanessa, Williams, Islah, Desaulniers, Jean‐Paul

“…Discovering new modifications for oligonucleotide therapeutics is essential for expanding its application to new targets and diseases. In this project, we…”
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Synthesis of folate-labeled siRNAs from a folate derivative phosphoramidite by Salim, Lidya, Desaulniers, Jean-Paul

“…With the recent success of GalNAc and the need for extra-hepatic RNAi delivery systems, other receptor-targeting ligands, like folate, have gained increased…”
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Synthesis, Derivatization and Photochemical Control of ortho‐Functionalized Tetrachlorinated Azobenzene‐Modified siRNAs by Hammill, Matthew L., Islam, Golam, Desaulniers, Jean‐Paul

“…We report the chemical synthesis and derivatization of an ortho‐functionalized tetrachlorinated azobenzene diol. A 4′,4‐dimethoxytrityl (DMT) phosphoramidite…”
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Synthesis, Derivatization and Photochemical Control of an ortho‐Functionalized Tetrafluorinated Azobenzene‐Modified siRNA by Hammill, Matthew L., Tsubaki, Kouta, Wang, Yuwei, Islam, Golam, Kitamura, Mitsuru, Okauchi, Tatsuo, Desaulniers, Jean‐Paul

“…We report the synthesis of an ortho‐functionalized tetrafluorinated azobenzene phosphoramidite for its site‐specific incorporation into RNA. The…”
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Pasteurization, storage conditions and viral concentration methods influence RT-qPCR detection of SARS-CoV-2 RNA in wastewater by Islam, Golam, Gedge, Ashley, Lara-Jacobo, Linda, Kirkwood, Andrea, Simmons, Denina, Desaulniers, Jean-Paul

“…The COVID-19 pandemic presents many public health challenges including the tracking of infected individuals from local to regional scales. Wastewater…”
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Cover Feature: Direct Conjugation of Gallium‐(III)‐Corroles to Short Interfering RNA(siRNA) Providing Real‐Time siRNA Imaging and Gene Silencing (ChemPlusChem 6/2024) by Giorgees, Ifrodet, Affe, Vanessa, Williams, Islah, Desaulniers, Jean‐Paul

“…Invited for this month′s cover is the group of Jean‐Paul Desaulniers at Ontario Tech University. The cover picture shows the successful conjugation of a…”
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Chemical strategies for strand selection in short-interfering RNAs by Varley, Andrew J, Desaulniers, Jean-Paul

“…Therapeutic small interfering RNAs (siRNAs) are double stranded RNAs capable of potent and specific gene silencing through activation of the RNA interference…”
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Effective carrier-free gene-silencing activity of sphingosine-modified siRNAs by Fernandez, Charlene, Giorgees, Ifrodet, Goss, Eva, Desaulniers, Jean-Paul

“…RNA interference (RNAi) is a natural cellular process that silences the expression of target genes in a sequence-specific way by mediating targeted mRNA…”
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Building siRNAs with Cubes: Synthesis and Evaluation of Cubane‐Modified siRNAs by Hammill, Matthew L., Salim, Lidya, Tsubaki, Kouta, Varley, Andrew J., Kitamura, Mitsuru, Okauchi, Tatsuo, Desaulniers, Jean‐Paul

“…Cubane molecules hold great potential for medicinal chemistry applications due to their inherent stability and low toxicity. In this study, we report the…”
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Synthesis of 5'-fluorophosphate-modified short-interfering RNAs by Varley, Andrew, Desaulniers, Jean-Paul

“…We have developed an improved scheme for the synthesis of a mono-fluorinated phosphoramidite for the 5'-modification of nucleic acids using standard…”
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The role of catchment population size, data normalization, and chronology of public health interventions on wastewater-based COVID-19 viral trends by Islam, Golam, Gedge, Ashley, Ibrahim, Reeta, de Melo, Tomas, Lara-Jacobo, Linda, Dlugosz, Thomas, Kirkwood, Andrea E., Simmons, Denina, Desaulniers, Jean-Paul

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic presented the most challenging global crisis in recent times. A pandemic caused by a…”
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Reversible control of RNA interference by siRNAzos by Hammill, Matthew L, Islam, Golam, Desaulniers, Jean-Paul

“…In this study, we report the reversible control of RNA interference using siRNAzos, a class of siRNAs that contain azobenzene. Herein, we demonstrate that it…”
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Direct Conjugation of Gallium(III)-Corroles to Short Interfering RNA (siRNA) Providing Real-Time siRNA Imaging and Gene Silencing by Giorgees, Ifrodet, Affe, Vanessa, Williams, Islah, Desaulniers, Jean-Paul

“…Invited for this month's cover is the group of Jean-Paul Desaulniers at Ontario Tech University. The cover picture shows the successful conjugation of a Ga…”
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Bromination of codeine and its derivatives: Revisiting a 95 year old process by Barmaki, Samira, Ali, Arlene, Desaulniers, Jean-Paul, Bolshan, Yuri

“…[Display omitted] •The manuscript describes the bromination of codeine.•The reaction features good yields and mild conditions.•A safe reagent N-bromoacetamide…”
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Synthesis and evaluation of modified siRNA molecules containing a novel glucose derivative by Salim, Lidya, Goss, Eva, Desaulniers, Jean-Paul

“…Chemical modifications are critical for the development of safe and effective siRNAs for downstream applications. In this study, we report the synthesis of a…”
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Stability and evaluation of siRNAs labeled at the sense strand with a 3′-azobenzene unit by Hammill, Matthew L., Patel, Ayushi, Alla, Maria Abd, Desaulniers, Jean-Paul

“…[Display omitted] siRNAs bearing a 3′-azobenzene derivative on the sense strand were evaluated for their gene silencing ability in mammalian cell culture and…”
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Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry by Efthymiou, Tim, Gong, Wei, Desaulniers, Jean-Paul

“…There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the…”
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Synthesis of Azobenzene Derivative Phosphoramidites for Incorporation into Oligonucleotides by Hammill, Matthew L, Desaulniers, Jean-Paul

“…This article contains the detailed synthesis and characterization protocols of azobenzene containing siRNAs, which have photoswitchable properties effectively…”
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Effective carrier-free gene-silencing activity of cholesterol-modified siRNAs by Salim, Lidya, McKim, Chris, Desaulniers, Jean-Paul

“…The use of short interfering RNAs (siRNAs) as therapeutics holds great promise, but chemical modifications must first be employed to improve their…”
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