Search Results - "Desale, Smita Eknath"

Role of dietary fatty acids in microglial polarization in Alzheimer's disease by Desale, Smita Eknath, Chinnathambi, Subashchandrabose

“…Microglial polarization is an utmost important phenomenon in Alzheimer's disease that influences the brain environment. Polarization depends upon the types of…”
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Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer's disease by Desale, Smita Eknath, Chinnathambi, Subashchandrabose

“…Alzheimer's disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal…”
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α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia by Desale, Smita Eknath, Chinnathambi, Subashchandrabose

“…Microglia, the resident immune cells, were found to be activated to inflammatory phenotype in Alzheimer's disease (AD). The extracellular burden of amyloid-β…”
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α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia by Desale, Smita Eknath, Chinnathambi, Subashchandrabose

“…Alzheimer’s disease (AD) is known by characteristic features, extracellular burden of amyloid-β and intracellular neuronal Tau. Microglia, the innate immune…”
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G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s disease by Desale, Smita Eknath, Chidambaram, Hariharakrishnan, Chinnathambi, Subashchandrabose

“…Alzheimer’s disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and…”
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The crosstalk between extracellular matrix proteins and Tau by Chinnathambi, Subashchandrabose, Desale, Smita Eknath

“…Alzheimer's disease is progressive neurodegenerative disease characterize by the presence of extracellular accumulation of amyloid-β plaques and intracellular…”
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α-Linolenic acid inhibits Tau aggregation and modulates Tau conformation by Desale, Smita Eknath, Dubey, Tushar, Chinnathambi, Subashchandrabose

“…Alzheimer's disease is characterized by important patho-proteins, which being composed of Amyloid-β plaques and intracellular neurofibrillary tangles of Tau…”
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Tau aggregates improve the Purinergic receptor P2Y12-associated podosome rearrangements in microglial cells by Chinnathambi, Subashchandrabose, Das, Rashmi, Desale, Smita Eknath

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease that is associated with protein misfolding, plaque accumulation, neuronal dysfunction,…”
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Biochemical and Biophysical Characterization of Tau and α-Linolenic Acid Vesicles In Vitro by Desale, Smita Eknath, Chidambaram, Hariharakrishnan, Chinnathambi, Subashchandrabose

“…Alzheimer's disease (AD) is characterized by the abnormal accumulation of disordered protein, that is, extracellular senile plaques of amyloid-β (Aβ) and…”
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α-Linolenic Acid Induces Microglial Activation and Extracellular Tau Internalization by Desale, Smita Eknath, Chidambaram, Hariharakrishnan, Chinnathambi, Subashchandrabose

“…Neuroinflammation is the brain condition that occurs due to the hyper-activation of brain's immune cells and microglia, over the stimulation of extracellular…”
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Interaction of Tau with G-Protein-Coupled Purinergic P2Y12 Receptor by Molecular Docking and Molecular Dynamic Simulation by Chidambaram, Hariharakrishnan, Desale, Smita Eknath, Chinnathambi, Subashchandrabose

“…Alzheimer's disease, a progressive neurological disorder, is characterized by the accumulation of neurofibrillary tangles and senile plaques by Tau and…”
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Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia by Chidambaram, Hariharakrishnan, Desale, Smita Eknath, Chinnathambi, Subashchandrabose

“…Microglia are the resident brain macrophage cells that are involved in constant surveillance of brain microenvironment. In Alzheimer's disease, microglia get…”
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Internalization and Endosomal Trafficking of Extracellular Tau in Microglia Improved by α-Linolenic Acid by Desale, Smita Eknath, Chidambaram, Hariharakrishnan, Qureshi, Tazeen, Chinnathambi, Subashchandrabose

“…Alzheimer's disease (AD) is distinguished by extracellular accumulation of amyloid-beta plaques and intracellular neurofibrillary tangles of Tau. Pathogenic…”
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Understanding Actin Remodeling in Neuronal Cells Through Podosomes by Qureshi, Tazeen, Desale, Smita Eknath, Chidambaram, Hariharakrishnan, Chinnathambi, Subashchandrabose

“…Cytoskeletal dysregulation forms an important aspect of many neurodegenerative diseases such as Alzheimer's disease. Cytoskeletal functions require the dynamic…”
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Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis by Chidambaram, Hariharakrishnan, Desale, Smita Eknath, Qureshi, Tazeen, Chinnathambi, Subashchandrabose

“…Microglia are scavengers of the brain environment that clear dead cells, debris, and microbes. In Alzheimer's disease, microglia get activated to phagocytose…”
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