Search Results - "Desai, Prashant J"

Reconstitution of the Kaposi's Sarcoma-Associated Herpesvirus Nuclear Egress Complex and Formation of Nuclear Membrane Vesicles by Coexpression of ORF67 and ORF69 Gene Products by DESAI, Prashant J, PRYCE, Erin N, HENSON, Brandon W, LUITWEILER, Eric M, COTHRAN, Jonathan

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Development and application of a high-content virion display human GPCR array by Syu, Guan-Da, Wang, Shih-Chin, Ma, Guangzhong, Liu, Shuang, Pearce, Donna, Prakash, Atish, Henson, Brandon, Weng, Lien-Chun, Ghosh, Devlina, Ramos, Pedro, Eichinger, Daniel, Pino, Ignacio, Dong, Xinzhong, Xiao, Jie, Wang, Shaopeng, Tao, Nongjian, Kim, Kwang Sik, Desai, Prashant J., Zhu, Heng

“…Human G protein-coupled receptors (GPCRs) respond to various ligands and stimuli. However, GPCRs rely on membrane for proper folding, making their biochemical…”
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Nelfinavir inhibition of Kaposi's sarcoma-associated herpesvirus protein expression and capsid assembly by Li, Maggie, Smith, Barbara J, Lee, Jaeyeun, Petr, Jennifer, Anders, Nicole M, Wiseman, Robyn, Rudek, Michelle A, Ambinder, Richard F, Desai, Prashant J

“…Antiviral therapies that target herpesviruses are clinically important. Nelfinavir is a protease inhibitor that targets the human immunodeficiency virus (HIV)…”
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Functional Domains of the Herpes Simplex Virus Type 1 Tegument Protein pUL37: The Amino Terminus is Dispensable for Virus Replication in Tissue Culture by Grzesik, Peter, Pryce, Erin N., Bhalala, Akshay, Vij, Mannika, Ahmed, Ray, Etienne, Lyns, Perez, Patric, McCaffery, J. Michael, Desai, Prashant J.

“…The herpes simplex virus type 1 (HSV-1) UL37 gene encodes for a multifunctional component of the virion tegument, which is necessary for secondary envelopment…”
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Interactions of the Kaposi's Sarcoma-Associated Herpesvirus Nuclear Egress Complex: ORF69 Is a Potent Factor for Remodeling Cellular Membranes by Luitweiler, Eric M, Henson, Brandon W, Pryce, Erin N, Patel, Varun, Coombs, Gavin, McCaffery, J Michael, Desai, Prashant J

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A Domain in the Herpes Simplex Virus 1 Triplex Protein VP23 Is Essential for Closure of Capsid Shells into Icosahedral Structures by HONG SEOK KIM, HANG, Eugene, DESAI, Jigisha, SOLE, Marieta, PRICE, Erin N, OKOYE, Mercy E, PERSON, Stanley, DESAI, Prashant J

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The Assembly Domain of the Small Capsid Protein of Kaposi's Sarcoma-Associated Herpesvirus by KREITLER, Dale, CAPUANO, Christopher M, HENSON, Brandon W, PRYCE, Erin N, ANACKER, Daniel, MCCAFFERY, J. Michael, DESAI, Prashant J

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Measuring Ligand Binding Kinetics to Membrane Proteins Using Virion Nano-oscillators by Ma, Guangzhong, Syu, Guan-Da, Shan, Xiaonan, Henson, Brandon, Wang, Shaopeng, Desai, Prashant J, Zhu, Heng, Tao, Nongjian

“…Membrane proteins play vital roles in cellular signaling processes and serve as the most popular drug targets. A key task in studying cellular functions and…”
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Genome-wide engineering of an infectious clone of herpes simplex virus type 1 using synthetic genomics assembly methods by Oldfield, Lauren M., Grzesik, Peter, Voorhies, Alexander A., Alperovich, Nina, MacMath, Derek, Najera, Claudia D., Chandra, Diya Sabrina, Prasad, Sanjana, Noskov, Vladimir N., Montague, Michael G., Friedman, Robert M., Desai, Prashant J., Vashee, Sanjay

“…Here, we present a transformational approach to genome engineering of herpes simplex virus type 1 (HSV-1), which has a large DNA genome, using synthetic…”
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Incorporation of the Kaposi’s sarcoma-associated herpesvirus capsid vertex-specific component (CVSC) into self-assembled capsids by Grzesik, Peter, MacMath, Derek, Henson, Brandon, Prasad, Sanjana, Joshi, Poorval, Desai, Prashant J.

“…•First biochemical studies that examine and discover interactions of the Kaposi’s sarcoma-associated herpesvirus (KSHV) capsid vertex-specific component…”
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Efficient size-independent chromosome delivery from yeast to cultured cell lines by Brown, David M, Chan, Yujia A, Desai, Prashant J, Grzesik, Peter, Oldfield, Lauren M, Vashee, Sanjay, Way, Jeffrey C, Silver, Pamela A, Glass, John I

“…The delivery of large DNA vectors (>100 000 bp) remains a limiting step in the engineering of mammalian cells and the development of human artificial…”
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Visualization of herpes simplex virus type 1 virions using fluorescent colors by Etienne, Lyns, Joshi, Poorval, Dingle, Laura, Huang, Eugene, Grzesik, Peter, Desai, Prashant J.

“…•Generation of new HSV-1 recombinant viruses expressing VP26 fluorescent protein fusions.•New fluorescent colors include Cerulean, Venus, yellow fluorescent…”
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Rapid and efficient in vitro excision of BAC sequences from herpesvirus genomes using Cre-mediated recombination by Grzesik, Peter, Ko, Nathan, Oldfield, Lauren M., Vashee, Sanjay, Desai, Prashant J.

“…Cre-mediated recombination is a widely used technique for the re-arrangement of DNA sequences that are bracketed by loxP recognition sites. This bacteriophage…”
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Plaquing of Herpes Simplex Viruses by Sadowski, Lauren A, Lesko, Gregory M, Suissa, Chad, Upadhyay, Rista, Desai, Prashant J, Margulies, Barry J

“…There are numerous published protocols for plaquing viruses, including references within primary literature for methodology. However, plaquing viruses can be…”
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Antiviral activity of a single-domain antibody immunotoxin binding to glycoprotein D of herpes simplex virus 2 by Geoghegan, Eileen M, Zhang, Hong, Desai, Prashant J, Biragyn, Arya, Markham, Richard B

“…Despite years of research dedicated to preventing the sexual transmission of herpes simplex virus 2 (HSV-2), there is still no protective vaccine or…”
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Nelfinavir inhibits maturation and export of herpes simplex virus 1 by Kalu, Nene N, Desai, Prashant J, Shirley, Courtney M, Gibson, Wade, Dennis, Phillip A, Ambinder, Richard F

“…Nelfinavir (NFV) is an HIV-1 protease inhibitor with demonstrated antiviral activity against herpes simplex virus 1 (HSV-1) and several other herpesviruses…”
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A Null Mutation in the UL36 Gene of Herpes Simplex Virus Type 1 Results in Accumulation of Unenveloped DNA-Filled Capsids in the Cytoplasm of Infected Cells by Desai, P J

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A hydrophobic domain within the small capsid protein of Kaposi's sarcoma-associated herpesvirus is required for assembly by Capuano, Christopher M, Grzesik, Peter, Kreitler, Dale, Pryce, Erin N, Desai, Keshal V, Coombs, Gavin, McCaffery, J Michael, Desai, Prashant J

“…Kaposi's sarcoma-associated herpesvirus (KSHV) capsids can be produced in insect cells using recombinant baculoviruses for protein expression. All six capsid…”
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Expression of the HSV-1 capsid protein VP19C in Escherichia coli: A single amino acid change overcomes an expression block of the full-length polypeptide by Henson, Brandon W., Johnson, Nicole, Bera, Alakesh, Okoye, Mercy E., Desai, Keshal Viren, Desai, Prashant J.

“…The herpesvirus triplex is a key structural feature of the capsids of these viruses. It is composed of a hetero-trimer of one molecule of VP19C and two…”
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Expression of the HSV-1 capsid protein VP19C in E. coli: A single amino acid change overcomes an expression block of the full-length polypeptide by Henson, Brandon W., Johnson, Nicole, Bera, Alakesh, Okoye, Mercy E., Desai, Keshal Viren, Desai, Prashant J.

“…The herpesvirus triplex is a key structural feature of the capsids of these viruses. It is composed of a hetero-trimer of one molecule of VP19C and two…”
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