Search Results - "Desai, Mitul"
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Target-responsive vasoactive probes for ultrasensitive molecular imaging
Published in Nature communications (13-05-2020)“…The ability to monitor molecules volumetrically throughout the body could provide valuable biomarkers for studies of healthy function and disease, but…”
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Journal Article -
2
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits
Published in Cell reports (Cambridge) (11-04-2017)“…Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models can provide an entry point to studying the molecular underpinnings of…”
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Journal Article -
3
Bacterial encapsulins as orthogonal compartments for mammalian cell engineering
Published in Nature communications (18-05-2018)“…We genetically controlled compartmentalization in eukaryotic cells by heterologous expression of bacterial encapsulin shell and cargo proteins to engineer…”
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Journal Article -
4
Molecular imaging with engineered physiology
Published in Nature communications (02-12-2016)“…In vivo imaging techniques are powerful tools for evaluating biological systems. Relating image signals to precise molecular phenomena can be challenging,…”
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Journal Article -
5
Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain
Published in eLife (21-12-2021)“…Molecular imaging could have great utility for detecting, classifying, and guiding treatment of brain disorders, but existing probes offer limited capability…”
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Journal Article -
6
CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria
Published in Scientific reports (31-03-2021)“…Phenylketonuria (PKU) is an autosomal recessive inborn error of l -phenylalanine (Phe) metabolism. It is caused by a partial or complete deficiency of the…”
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Journal Article -
7
Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks
Published in eLife (03-12-2016)“…Adult neurogenesis supports performance in many hippocampal dependent tasks. Considering the small number of adult-born neurons generated at any given time, it…”
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Journal Article -
8
Characterization of the functional MRI response temporal linearity via optical control of neocortical pyramidal neurons
Published in The Journal of neuroscience (19-10-2011)“…The blood oxygenation level-dependent (BOLD) signal serves as the basis for human functional MRI (fMRI). Knowledge of the properties of the BOLD signal, such…”
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Journal Article -
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Strong Medicine: The Pharmaceutical Industry's Compact with Society
Published in Georgetown journal of international affairs (01-04-2006)“…Places India's move to comply with the Agreement on Trade Related Aspects of International Property Rights (TRIPS), to which all members of the World Trade…”
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Journal Article -
10
Modelling of Hampshire Adult Services—gearing up for future demands
Published in Health care management science (01-06-2008)“…This paper describes a study to investigate future demand from older people for social care services in Hampshire, UK. The study used system dynamics to…”
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Journal Article -
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Optogenetic Stimulation Combined with High-Field fMRI (Opto-fMRI): A New Method for Examination of Evoked BOLD Responses and Functional Connectivity
Published 01-01-2011“…Behaviors and brain disorders involve neural circuits that are widely distributed in the brain. The ability to map the functional connectivity of distributed…”
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Dissertation -
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Modelling future demand for long-term care
Published 01-01-2011“…This research was jointly funded by the Economic and Social Research Council (ESRC) and the Engineering and Physical Sciences Research Council (EPSRC). As…”
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Dissertation -
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Rosalynn Carter pioneered supporting caregivers
Published in USA today (Arlington, Va.) (07-12-2023)Get full text
Newspaper Article -
14
Optogenetic Stimulation Combined with High-Field fMRI (Opto-fMRI): A New Method for Examination of Evoked BOLD Responses and Functional Connectivity
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Dissertation