Search Results - "Desai, Mahesh S."

The impact of the gut microbiome on extra-intestinal autoimmune diseases by Miyauchi, Eiji, Shimokawa, Chikako, Steimle, Alex, Desai, Mahesh S., Ohno, Hiroshi

“…The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the past few decades. Thus, in addition to the classical risk factors for ADs,…”
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A microfluidics-based in vitro model of the gastrointestinal human–microbe interface by Shah, Pranjul, Fritz, Joëlle V., Glaab, Enrico, Desai, Mahesh S., Greenhalgh, Kacy, Frachet, Audrey, Niegowska, Magdalena, Estes, Matthew, Jäger, Christian, Seguin-Devaux, Carole, Zenhausern, Frederic, Wilmes, Paul

“…Changes in the human gastrointestinal microbiome are associated with several diseases. To infer causality, experiments in representative models are essential,…”
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A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility by Desai, Mahesh S., Seekatz, Anna M., Koropatkin, Nicole M., Kamada, Nobuhiko, Hickey, Christina A., Wolter, Mathis, Pudlo, Nicholas A., Kitamoto, Sho, Terrapon, Nicolas, Muller, Arnaud, Young, Vincent B., Henrissat, Bernard, Wilmes, Paul, Stappenbeck, Thaddeus S., Núñez, Gabriel, Martens, Eric C.

“…Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and…”
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Bacteroidales ectosymbionts of gut flagellates shape the nitrogen-fixing community in dry-wood termites by Desai, Mahesh S, Brune, Andreas

“…Although it is well documented that the lack of nitrogen in the diet of wood-feeding termites is compensated by the nitrogen-fixing capacity of their gut…”
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Maternal diet and gut microbiome composition modulate early‐life immune development by Grant, Erica T, Boudaud, Marie, Muller, Arnaud, Macpherson, Andrew J, Desai, Mahesh S

“…In early life, the intestinal mucosa and immune system undergo a critical developmental process to contain the expanding gut microbiome while promoting…”
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Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility by Wolter, Mathis, Grant, Erica T, Boudaud, Marie, Pudlo, Nicholas A, Pereira, Gabriel V, Eaton, Kathryn A, Martens, Eric C, Desai, Mahesh S

“…The erosion of the colonic mucus layer by a dietary fiber-deprived gut microbiota results in heightened susceptibility to an attaching and effacing pathogen,…”
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Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium by Neumann, Mareike, Steimle, Alex, Grant, Erica T., Wolter, Mathis, Parrish, Amy, Willieme, Stéphanie, Brenner, Dirk, Martens, Eric C., Desai, Mahesh S.

“…The change of dietary habits in Western societies, including reduced consumption of fiber, is linked to alterations in gut microbial ecology. Nevertheless,…”
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Nitrogen fixation in distinct microbial niches within a chemoautotrophy-driven cave ecosystem by Desai, Mahesh S, Assig, Karoline, Dattagupta, Sharmishtha

“…Microbial sulfur and carbon cycles in ecosystems driven by chemoautotrophy—present at deep-sea hydrothermal vents, cold seeps and sulfidic caves—have been…”
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Concentrated Raw Fibers Enhance the Fiber-Degrading Capacity of a Synthetic Human Gut Microbiome by Steimle, Alex, Neumann, Mareike, Grant, Erica T., Turner, Jonathan D., Desai, Mahesh S.

“…The consumption of prebiotic fibers to modulate the human gut microbiome is a promising strategy to positively impact health. Nevertheless, given the…”
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The extracellular RNA complement of Escherichia coli by Ghosal, Anubrata, Upadhyaya, Bimal Babu, Fritz, Joëlle V., Heintz‐Buschart, Anna, Desai, Mahesh S., Yusuf, Dilmurat, Huang, David, Baumuratov, Aidos, Wang, Kai, Galas, David, Wilmes, Paul

“…The secretion of biomolecules into the extracellular milieu is a common and well‐conserved phenomenon in biology. In bacteria, secreted biomolecules are not…”
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Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut by Gaifem, Joana, Mendes-Frias, Ana, Wolter, Mathis, Steimle, Alex, Garzón, Maria Jose, Ubeda, Carles, Nobre, Clarisse, González, Abigail, Pinho, Salomé S, Cunha, Cristina, Carvalho, Agostinho, Castro, António Gil, Desai, Mahesh S, Rodrigues, Fernando, Silvestre, Ricardo

“…Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract. The etiology of IBD remains elusive, but the disease is…”
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Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier by Martens, Eric C., Neumann, Mareike, Desai, Mahesh S.

“…The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of…”
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Dietary fibers boost gut microbiota-produced B vitamin pool and alter host immune landscape by Grant, Erica T, Parrish, Amy, Boudaud, Marie, Hunewald, Oliver, Hirayama, Akiyoshi, Ollert, Markus, Fukuda, Shinji, Desai, Mahesh S

“…Dietary fibers can alter microbial metabolic output in support of healthy immune function; however, the impact of distinct fiber sources and immunomodulatory…”
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From meta-omics to causality: experimental models for human microbiome research by Fritz, Joëlle V, Desai, Mahesh S, Shah, Pranjul, Schneider, Jochen G, Wilmes, Paul

“…Large-scale 'meta-omic' projects are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A…”
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Dietary Modulation Alters Susceptibility to Listeria monocytogenes and Salmonella Typhimurium with or without a Gut Microbiota by Wolter, Mathis, Steimle, Alex, Parrish, Amy, Zimmer, Jacques, Desai, Mahesh S

“…Food safety has considerably improved worldwide, yet infections with foodborne human enteric pathogens, such as spp. and Salmonella spp., still cause numerous…”
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Multicomponent (bio)markers for obesity risk prediction: a scoping review protocol by Vahid, Farhad, Dessenne, Coralie, Tur, Josep A, Bouzas, Cristina, Devaux, Yvan, Malisoux, Laurent, Monserrat-Mesquida, Margalida, Sureda, Antoni, Desai, Mahesh S, Turner, Jonathan D, Lamy, Elsa, Perez-Jimenez, Maria, Ravn-Haren, Gitte, Andersen, Rikke, Forberger, Sarah, Nagrani, Rajini, Ouzzahra, Yacine, Fontefrancesco, Michele Filippo, Onorati, Maria Giovanna, Bonetti, Gino Gabriel, de-Magistris, Tiziana, Bohn, Torsten

“…IntroductionDespite international efforts, the number of individuals struggling with obesity is still increasing. An important aspect of obesity prevention…”
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Quantitative assay to detect bacterial glycan-degrading enzyme activities in mouse and human fecal samples by Steimle, Alex, Grant, Erica T., Desai, Mahesh S.

“…The gut microbiome expresses a multitude of enzymes degrading polysaccharides in dietary plant fibers and in host-secreted mucus. The quantitative detection of…”
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A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria by Kreft, Luisa, Schepers, Aloys, Hils, Miriam, Swiontek, Kyra, Flatley, Andrew, Janowski, Robert, Mirzaei, Mohammadali Khan, Dittmar, Michael, Chakrapani, Neera, Desai, Mahesh S., Eyerich, Stefanie, Deng, Li, Niessing, Dierk, Fischer, Konrad, Feederle, Regina, Blank, Simon, Schmidt-Weber, Carsten B., Hilger, Christiane, Biedermann, Tilo, Ohnmacht, Caspar

“…The alpha-Gal epitope (α-Gal) with the determining element galactose-α1,3-galactose can lead to clinically relevant allergic reactions and rejections in…”
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Constructing a gnotobiotic mouse model with a synthetic human gut microbiome to study host–microbe cross talk by Steimle, Alex, De Sciscio, Alessandro, Neumann, Mareike, Grant, Erica T., Pereira, Gabriel V., Ohno, Hiroshi, Martens, Eric C., Desai, Mahesh S.

“…Reproducible in vivo models are necessary to address functional aspects of the gut microbiome in various diseases. Here, we present a gnotobiotic mouse model…”
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Strict cospeciation of devescovinid flagellates and Bacteroidales ectosymbionts in the gut of dry-wood termites (Kalotermitidae) by Desai, Mahesh S, Strassert, Jürgen F.H, Meuser, Katja, Hertel, Horst, Ikeda-Ohtsubo, Wakako, Radek, Renate, Brune, Andreas

“…The surface of many termite gut flagellates is colonized with a dense layer of bacteria, yet little is known about the evolutionary relationships of such…”
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