Search Results - "Desai, Biva"

The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase by Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N

“…RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1…”
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Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration by Desai, Biva M, Oliver-Krasinski, Jennifer, De Leon, Diva D, Farzad, Cyrus, Hong, Nankang, Leach, Steven D, Stoffers, Doris A

“…It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic…”
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Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]­thiazol-5-ylamino)-6‑(tert-butylsulfonyl)­quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases by Haile, Pamela A, Casillas, Linda N, Votta, Bartholomew J, Wang, Gren Z, Charnley, Adam K, Dong, Xiaoyang, Bury, Michael J, Romano, Joseph J, Mehlmann, John F, King, Bryan W, Erhard, Karl F, Hanning, Charles R, Lipshutz, David B, Desai, Biva M, Capriotti, Carol A, Schaeffer, Michelle C, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Nagilla, Rakesh, Rivera, Elizabeth J, Sun, Helen H, Kenna, John K, Beal, Allison M, Ouellette, Michael T, Kelly, Mike, Stemp, Gillian, Convery, Máire A, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Marquis, Robert W

“…RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including…”
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Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat by STOFFERS, Doris A, DESAI, Biva M, DELEON, Diva D, SIMMONS, Rebecca A

“…Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat Doris A. Stoffers 1 , Biva M. Desai 1 , Diva D. DeLeon 1 2 and…”
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Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel by Haile, Pamela A, Casillas, Linda N, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Hughes, Terry V, DeMartino, Michael P, Wang, Gren Z, Romano, Joseph J, Dong, Xiaoyang, Plotnikov, Nikolay V, Lakdawala, Ami S, Convery, Maire A, Votta, Bartholomew J, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, LePage, Carol, Ouellette, Michael T, Totoritis, Rachel D, Donovan, Brian T, Brown, Barry S, Chaudhary, Khuram W, Gough, Peter J, Bertin, John, Marquis, Robert W

“…RIP2 kinase was recently identified as a therapeutic target for a variety of autoimmune diseases. We have reported previously a selective…”
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Exendin-4 Normalizes Islet Vascularity in Intrauterine Growth Restricted Rats: Potential Role of VEGF by Ham, J Nina, Crutchlow, Michael F, Desai, Biva M, Simmons, Rebecca A, Stoffers, Doris A

“…Intrauterine growth restriction (IUGR) induced by uterine artery ligation in pregnant rats leads to low birth weight and early insulin secretory defects…”
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Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel by Haile, Pamela A., Casillas, Linda N., Bury, Michael J., Mehlmann, John F., Singhaus, Robert, Charnley, Adam K., Hughes, Terry V., DeMartino, Michael P., Wang, Gren Z., Romano, Joseph J., Dong, Xiaoyang, Plotnikov, Nikolay V., Lakdawala, Ami S., Duraiswami, Chaya, Convery, Maire A., Votta, Bartholomew J., Lipshutz, David B., Desai, Biva M., Swift, Barbara, Capriotti, Carol A., Berger, Scott B., Mahajan, Mukesh K., Reilly, Michael A., Rivera, Elizabeth J., Sun, Helen H., Nagilla, Rakesh, LePage, Carol, Ouellette, Michael T., Totoritis, Rachel D., Donovan, Brian T., Brown, Barry S., Chaudhary, Khuram W., Gough, Peter J., Bertin, John, Marquis, Robert W.

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Identification of PCIF1, a POZ Domain Protein That Inhibits PDX-1 (MODY4) Transcriptional Activity by Liu, Aihua, Desai, Biva M., Stoffers, Doris A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification and characterization of potent, selective small molecule RIP2 kinase inhibitors (INM6P.422) by Lipshutz, David, Haile, Pamela, Cassillas, Linda, Desai, Biva, Capriotti, Carol, Swift, Barbara, Berger, Scott, Sun, Helen, Mahajan, Mukesh, Nagilla, Rakesh, Reilly, Michael, Gough, Peter, Bertin, John, Votta, Bart

“…Abstract NOD1 and NOD2 are cytoplasmic PRRs, which bind peptides derived from bacterial peptidoglycans. Signaling via these receptors involves recruitment and…”
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Use of novel small molecule inhibitors to investigate the role of endogenous RIP2 kinase activity in modulating NOD2/RIP2-dependent cytokine signaling (172.4) by Desai, Biva, Haile, Pamela, Casillas, Linda, Gough, Peter, Bertin, John, Votta, Bart

“…Abstract RIP2 is a Ser/Thr protein kinase, which undergoes autophosphorylation and activates NF-κB and MAPKs following stimulation of the upstream NOD1/NOD2…”
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Developmental Expression and Structure-Function Regulation of PCIF1, a PDX1 Coregulator by Liu, Aihua, Desai, Biva, Stoffers, Doris A

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Tu1921 Selective Inhibitors of RIP2 Kinase Activity Reduce PRO-Inflammatory Cytokine Production in IBD Mucosal Biopsy Cultures and Inflammation in Murine TNBS-Induced Colitis by Gough, Peter, Votta, Bart, Casillas, Linda, Haile, Pamela, Lipshutz, David, Desai, Biva, Swift, Barbara, Capriotti, Carol Ann, Reilly, Michael, Foley, Kevin P, Biancheri, Paolo, Vossenkämper, Anna, MacDonald, Thomas T, Marquis, Robert W, Bertin, John

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Preexisting pancreatic acinar cells contribute to acinar cell, but not islet [beta] cell, regeneration by Desai, Biva M, Oliver-Krasinski, Jennifer, De Leon, Diva D, Cyrus Farzad

“…It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic…”
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Mature Pancreatic Acinar Cells Do Not Transdifferentiate into Islet Endocrine Cells after Partial Pancreatectomy or Pancreatic Duct Ligation in Mice by Desai, Biva, Cyrus Farzad, De Leon, Diva, Sui Guoping

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