Search Results - "Des Rosiers, C"

Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency by Khairallah, M, Khairallah, R.J, Young, M.E, Allen, B.G, Gillis, M.A, Danialou, G, Deschepper, C.F, Petrof, B.J, Des Rosiers, C

“…We recently demonstrated early metabolic alterations in the dystrophin-deficient mdx heart that precede overt cardiomyopathy and may represent an early…”
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Cardiac anaplerosis in health and disease: food for thought by Des Rosiers, Christine, Labarthe, François, Lloyd, Steven G, Chatham, John C

“…There has been a resurgence of interest for the field of cardiac metabolism catalysed by the increased need for new therapeutic targets for patients with heart…”
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Validation of fatty acid intakes estimated by a food frequency questionnaire using erythrocyte fatty acid profiling in the Montreal Heart Institute Biobank by Turcot, V, Brunet, J, Daneault, C, Tardif, J. C, Des Rosiers, C, Lettre, G

“…BACKGROUND: To improve the prevention, treatment and risk prediction of cardiovascular diseases, genetic markers and gene–diet interactions are currently being…”
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Dystrophin‐deficient cardiomyocytes are abnormally vulnerable to mechanical stress‐induced contractile failure and injury by Danialou, Gawiyou, Comtois, Alain S., Dudley, Roy, Karpati, George, Vincent, Geneviève, Des Rosiers, Christine, Petrof, Basil J.

“…ABSTRACT Although absence of the cytoskeletal protein dystrophin leads to dilated cardiomyopathy in humans, the functional role of dystrophin in cardiac muscle…”
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307 Impact of a single mixed mediterranean-type meal relative to a high-fat meal on metabolic markers and postprandial endothelial function by Lacroix, S, Des Rosiers, C, Gayda, M, Tardif, J, Nigam, A

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Myocardial phenotyping using isotopomer analysis of metabolic fluxes by Des Rosiers, C, Chatham, J C

“…Over the past 20 years, stable isotopes combined with isotopomer analysis have proven to be a powerful approach to probe the dynamics of metabolism in various…”
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Chronic activation of cardioprotective cGMP signaling involves changes in energy substrate selection by Khairallah, R, Young, M.E, Allen, B, Lopaschuk, G, Deschepper, C, Des Rosiers, C

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Quantitative gas chromatographic-mass spectrometric assay of 4-hydroxynonenal bound to thiol proteins in ischemic/reperfused rat hearts by Vronneau, Marc, Comte, Blandine, Des Rosiers, Christine

“…Increasing evidence indicates that protein-aldehyde adducts involving mostly 4-hydroxynonenal could be causally involved in both pathophysiological and…”
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Acute hibernation decreases myocardial pyruvate carboxylation and citrate release by Panchal, A R, Comte, B, Huang, H, Dudar, B, Roth, B, Chandler, M, Des Rosiers, C, Brunengraber, H, Stanley, W C

“…In the well-perfused heart, pyruvate carboxylation accounts for 3-6% of the citric acid cycle (CAC) flux, and CAC carbon is lost via citrate release. We…”
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Higher circulating 4-hydroxynonenal-protein thioether adducts correlate with more severe diastolic dysfunction in spontaneously hypertensive rats by Asselin, C, Shi, Y, Clément, R, Tardif, J C, Des Rosiers, C

“…Accumulating evidence supports a role of 4-hydroxynonenal (4HNE) in oxidative-stress related diseases, but its specific contribution to disease development…”
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P152 La leucine, un puissant inhibiteur du captage de glucose cardiaque by Renguet, E, Ginion, A, Gélinas, R, Auquier, J, Hue, L, Des Rosiers, C, Vanoverschelde, J, Horman, S, Beauloye, C, Bertrand, L

“…Introduction La leucine est un acide aminé branché capable d’induire une résistance à l’insuline dans le muscle et le tissu adipeux. Le mécanisme proposé pour…”
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Pseudoketogenesis in the perfused rat heart by Fink, G, Desrochers, S, Des Rosiers, C, Garneau, M, David, F, Daloze, T, Landau, B R, Brunengraber, H

“…Ketogenesis is usually measured in vivo by dilution of tracers of (3R)-hydroxybutyrate or acetoacetate. We show that, in perfused working rat hearts, the…”
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Rates of gluconeogenesis and citric acid cycle in perfused livers, assessed from the mass spectrometric assay of the 13C labeling pattern of glutamate by Di Donato, L. (Notre-Dame Hospital, Montreal, Canada), Des Rosiers, C, Montgomery, J.A, David, F, Garneau, M, Brunengraber, H

“…Absolute rates of gluconeogenesis and of the citric acid cycle were assessed in livers isolated from 24-h starved rats, perfused with physiological…”
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Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates by Des Rosiers, C, Fernandez, C A, David, F, Brunengraber, H

“…The reversal of the mitochondrial isocitrate dehydrogenase reaction was investigated in rat livers perfused with [U-13C5]glutamate or [U-13C5]glutamine. The…”
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Pseudoketogenesis in hepatectomized dogs by Des Rosiers, C, Montgomery, J A, Garneau, M, David, F, Mamer, O A, Daloze, P, Toffolo, G, Cobelli, C, Landau, B R, Brunengraber, H

“…Overestimation of ketone body turnover in vivo, measured by tracer kinetics, could occur if specific activity or molar percent enrichment is diluted in…”
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PathQuant: A bioinformatic tool to quantitatively annotate the relationship between genes and metabolites through metabolic pathway mapping by Therrien‐Laperrière, Sandra, Cherkaoui, S., Boucher, G., Jourdan, F., Lettre, G., Rioux, J. D., Des Rosiers, C.

“…Abstract only Background & Objective The integration of genome wide association studies (GWAS) with metabolomics, termed mGWAS, offers a tremendous opportunity…”
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Effects and metabolism of fumarate in the perfused rat heart. A 13C mass isotopomer study by Laplante, A, Vincent, G, Poirier, M, Des Rosiers, C

“…The cardioprotective effects of fumarate have been linked to its metabolism to succinate through both oxidative and reductive pathways. To date, the relative…”
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Nonhomogeneous labeling of liver mitochondrial acetyl-CoA by DES ROSIERS, C, DAVID, F, GARNEAU, M, BRUNENGRABER, H

“…The specific activity of carbons 1 and 2 of plasma acetoacetate has been used as a measure of the specific activity of liver mitochondrial acetyl-CoA in tracer…”
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Mitochondrial vulnerability and increased susceptibility to nutrient-induced cytotoxicity in fibroblasts from leigh syndrome French canadian patients by Burelle, Yan, Bemeur, Chantal, Rivard, Marie-Eve, Thompson Legault, Julie, Boucher, Gabrielle, Morin, Charles, Coderre, Lise, Des Rosiers, Christine

“…Mutations in LRPPRC are responsible for the French Canadian variant of Leigh Syndrome (LSFC), a severe disorder characterized biochemically by a…”
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Acyloin production from aldehydes in the perfused rat heart : the potential role of pyruvate dehydrogenase by MONTGOMERY, J. A, JETTE, M, HUOT, S, DES ROSIERS, C

“…Aldehydes represent an important class of cytotoxic products derived from free radical-induced lipid peroxidation which may contribute to reperfusion injury…”
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