Search Results - "Dervan, P B"

Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands by Dervan, Peter B, White, Sarah, Szewczyk, Jason W, Turner, James M, Baird, Eldon E

“…The design of synthetic ligands that read the information stored in the DNA double helix has been a long-standing goal at the interface of chemistry and…”
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Regulation of gene expression by small molecules by Gottesfeld, Joel M, Neely, Laura, Trauger, John W, Baird, Eldon E, Dervan, Peter B

“…Small molecules that target specific DNA sequences have the potential to control gene expression. Ligands designed for therapeutic application must bind any…”
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Sequence-specific recognition of double helical RNA and RNA.DNA by triple helix formation by HOGYU HAN, DERVAN, P. B

“…The stabilities of eight triple helical pyrimidine.purine.pyrimidine structures comprised of identical sequence but different RNA (R) or DNA (D) strand…”
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Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes by Trauger, J W, Dervan, P B

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Toward Rules for 1:1 Polyamide:DNA Recognition by Urbach, Adam R., Dervan, Peter B.

“…Polyamides composed of four amino acids, imidazole (Im), pyrrole (Py), hydroxypyrrole (Hp), and β-alanine (β), are synthetic ligands that form highly stable…”
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Molecular recognition of DNA by small molecules by Dervan, Peter B.

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Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation by Beal, Peter A., Dervan, Peter B.

“…Relative orientations of the DNA strands within a purine.purine.pyrimidine triple helix have been determined by affinity cleaving. A purine-rich…”
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Sequence-Specific Trapping of Topoisomerase I by DNA Binding Polyamide−Camptothecin Conjugates by Wang, Clay C. C, Dervan, Peter B

“…Hairpin pyrrole−imidazole polyamides are synthetic ligands that bind in the minor groove of DNA with affinities and specificities comparable to those of DNA…”
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Antiparallel Side-by-Side Dimeric Motif for Sequence-Specific Recognition in the Minor Groove of DNA by the Designed Peptide 1-Methylimidazole-2 Carboxamide Netropsin by Mrksich, Milan, Wade, Warren S., Dwyer, Tammy J., Geierstanger, Bernhard H., Wemmer, David E., Dervan, Peter B.

“…The designed peptide 1-methylimidazole-2-carboxamide netropsin (2-ImN) binds specifically to the sequence 5'-TGACT-3'. Direct evidence from NMR spectroscopy is…”
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Design of peptides that bind in the minor groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' sequences by a dimeric side-by-side motif by Wade, Warren S, Mrksich, Milan, Dervan, Peter B

“…The designed peptides pyridine-2-carboxamide-netropsin (2-PyN) and 1-methylimidazole-2-carboxamide-netropsin (2-ImN) are crescent-shaped synthetic analogs of…”
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Design of Sequence-Specific DNA-Binding Molecules by Dervan, Peter B.

“…Base sequence information can be stored in the local structure of right-handed double-helical DNA (B-DNA). The question arises as to whether a set of rules for…”
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Thermodynamic Characterization of the Stability and the Melting Behavior of a DNA Triplex: A Spectroscopic and Calorimetric Study by Plum, G. Eric, Park, Young-Whan, Singleton, Scott F., Dervan, Peter B., Breslauer, Kenneth J.

“…We report a complete thermodynamic characterization of the stability and the melting behavior of an oligomeric DNA triplex. The triplex chosen for study forms…”
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Recognition of the DNA minor groove by pyrrole-imidazole polyamides by Dervan, Peter B, Edelson, Benjamin S

“…Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine…”
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Targeting the ets binding site of the HER2/neu promoter with pyrrole-imidazole polyamides by Chiang, S Y, Burli, R W, Benz, C C, Gawron, L, Scott, G K, Dervan, P B, Beerman, T A

“…Three DNA binding polyamides () were synthesized that bind with high affinity (K(a) = 8.7. 10(9) m(-1) to 1.4. 10(10) m(-1)) to two 7-base pair sequences…”
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Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation by Moser, Heinz E., Dervan, Peter B.

“…Homopyrimidine oligodeoxyribonucleotides with EDTA$\cdot $Fe attached at a single position bind the corresponding homopyrimidine-homopurine tracts within large…”
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Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation by Maher, Louis J., Wold, Barbara, Dervan, Peter B.

“…Oligonucleotides that bind to duplex DNA in a sequence-specific manner by triple helix formation offer an approach to the experimental manipulation of…”
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Influence of pH on the equilibrium association constants for oligodeoxyribonucleotide-directed triple helix formation at single DNA sites by Singleton, Scott F, Dervan, Peter B

“…The energetics of oligodeoxyribonucleotide-directed triple helix formation for the pyrimidine.purine.pyrimidine structural motif were determined over the pH…”
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Reagents for the site-specific cleavage of megabase DNA by Dervan, Peter B

“…The physical mapping of chromosomes will be facilitated by methods of breaking large DNA into manageable fragments, or cutting uniquely at genetic markers of…”
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Binding Site Size Limit of the 2:1 Pyrrole-Imidazole Polyamide-DNA Motif by Kelly, James J., Baird, Eldon E., Dervan, Peter B.

“…Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids can be combined in antiparallel side-by-side dimeric complexes for…”
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Analysis of promoter-specific repression by triple-helical DNA complexes in a eukaryotic cell-free transcription system by Maher, L. James, Dervan, Peter B, Wold, Barbara

“…A site-specific triple-helical DNA complex has previously been shown to inhibit DNA binding by eukaryotic transcription factor Sp1. To examine the functional…”
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