Search Results - "Derudder, Emmanuel"

Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model by Zhang, Baochun, Kracker, Sven, Yasuda, Tomoharu, Casola, Stefano, Vanneman, Matthew, Hömig-Hölzel, Cornelia, Wang, Zhe, Derudder, Emmanuel, Li, Shuang, Chakraborty, Tirtha, Cotter, Shane E., Koyama, Shohei, Currie, Treeve, Freeman, Gordon J., Kutok, Jeffery L., Rodig, Scott J., Dranoff, Glenn, Rajewsky, Klaus

“…B cells infected by Epstein-Barr virus (EBV), a transforming virus endemic in humans, are rapidly cleared by the immune system, but some cells harboring the…”
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The B-cell antigen receptor integrates adaptive and innate immune signals by Otipoby, Kevin L., Waisman, Ari, Derudder, Emmanuel, Srinivasan, Lakshmi, Franklin, Andrew, Rajewsky, Klaus

“…B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or…”
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A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis by Olson, William J., Jakic, Bojana, Labi, Verena, Woelk, Johannes, Derudder, Emmanuel, Baier, Gottfried, Hermann-Kleiter, Natascha

“…B cells are key mediators of humoral immunity. Mature B cells fall into various sub-classes that can be separated by their ontogeny, expression of cell surface…”
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miR-142 favors naïve B cell residence in peripheral lymph nodes by Hagen, Magdalena, Chakraborty, Tirtha, Olson, William J., Heitz, Martin, Hermann-Kleiter, Natascha, Kimpel, Janine, Jenewein, Brigitte, Pertoll, Johanna, Labi, Verena, Rajewsky, Klaus, Derudder, Emmanuel

“…B lymphocyte development proceeds through a well-ordered sequence of steps, leading to the formation of a sizeable mature B population recognizing a diversity…”
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Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells by Derudder, Emmanuel, Herzog, Sebastian, Labi, Verena, Yasuda, Tomoharu, Köchert, Karl, Janz, Martin, Villunger, Andreas, Schmidt-Supprian, Marc, Rajewsky, Klaus

“…Although canonical NF-κB signaling is crucial to generate a normal mature B-cell compartment, its role in the persistence of resting mature B cells is…”
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NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells by Sasaki, Yoshiteru, Calado, Dinis P, Derudder, Emmanuel, Zhang, Baochun, Shimizu, Yuri, Mackay, Fabienne, Nishikawa, Shin-ichi, Rajewsky, Klaus, Schmidt-Supprian, Marc

“…BAFF-R-dependent activation of the alternative NF-κB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression of NIK and…”
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IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors by Authier, Hélène, Billot, Katy, Derudder, Emmanuel, Bordereaux, Didier, Rivière, Pierre, Rodrigues-Ferreira, Sylvie, Nahmias, Clara, Baud, Véronique

“…TNFα is a potent cytokine that plays a critical role in numerous cellular processes, particularly immune and inflammatory responses, programmed cell death,…”
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Cell signaling and the aging of B cells by Labi, Verena, Derudder, Emmanuel

“…The uniqueness of each B cell lies in the structural diversity of the B-cell antigen receptor allowing the virtually limitless recognition of antigens, a…”
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The miR-142 miRNAs: Shaping the naïve immune system by Olson, William J., Derudder, Emmanuel

“…•The miR-142 locus is preferentially expressed among hematopoietic cells.•miR-142 miRNAs contribute to the generation of the full range of immune cells.•These…”
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TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells by Schoeler, Katia, Aufschnaiter, Andreas, Messner, Simon, Derudder, Emmanuel, Herzog, Sebastian, Villunger, Andreas, Rajewsky, Klaus, Labi, Verena

“…Upon activation by antigen, B cells form germinal centres where they clonally expand and introduce affinity‐enhancing mutations into their B‐cell receptor…”
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Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation by Sasaki, Yoshiteru, Derudder, Emmanuel, Hobeika, Elias, Pelanda, Roberta, Reth, Michael, Rajewsky, Klaus, Schmidt-Supprian, Marc

“…The maintenance of mature B cells hinges on signals emitted from the BAFF-R cell-surface receptor, but the nature of these signals is incompletely understood…”
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T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia by Fogli, Laura K, Sundrud, Mark S, Goel, Swati, Bajwa, Sofia, Jensen, Kari, Derudder, Emmanuel, Sun, Amy, Coffre, Maryaline, Uyttenhove, Catherine, Van Snick, Jacques, Schmidt-Supprian, Marc, Rao, Anjana, Grunig, Gabriele, Durbin, Joan, Casola, Stefano, Casola, Stefano S, Rajewsky, Klaus, Koralov, Sergei B

“…Th17 cells are a proinflammatory subset of effector T cells that have been implicated in the pathogenesis of asthma. Their production of the cytokine IL-17 is…”
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Control of NF-κB activity by proteolysis by Baud, Véronique, Derudder, Emmanuel

“…NF-κB transcription factors are critical regulators of many biological processes such as innate and adaptive immune responses, inflammation, cell proliferation…”
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Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat by Labi, Verena, Peng, Siying, Klironomos, Filippos, Munschauer, Mathias, Kastelic, Nicolai, Chakraborty, Tirtha, Schoeler, Katia, Derudder, Emmanuel, Martella, Manuela, Mastrobuoni, Guido, Hernandez-Miranda, Luis R, Lahmann, Ines, Kocks, Christine, Birchmeier, Carmen, Kempa, Stefan, Quintanilla-Martinez de Fend, Leticia, Landthaler, Markus, Rajewsky, Nikolaus, Rajewsky, Klaus

“…Knockout of the ubiquitously expressed miRNA-17∼92 cluster in mice produces a lethal developmental lung defect, skeletal abnormalities, and blocked B…”
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Canonical NF-[kappa]B signaling is uniquely required for the long-term persistence of functional mature B cells by Derudder, Emmanuel, Herzog, Sebastian, Labi, Verena, Yasuda, Tomoharu, Köchert, Karl, Janz, Martin, Villunger, Andreas, Schmidt-Supprian, Marc, Rajewsky, Klaus

“…Although canonical NF-...B signaling is crucial to generate a normal mature B-cell compartment, its role in the persistence of resting mature B cells is…”
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Development of immunoglobulin λ-chain-positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals by Zha, Shan, Wang, Jing, van Loo, Geert, Cadera, Emily J, Schmidt-Supprian, Marc, Rajewsky, Klaus, Fox, Casey J, Pasparakis, Manolis, Vahl, J Christoph, Derudder, Emmanuel, Schlissel, Mark S

“…How transcription factor NF-κB influences B cell development remains enigmatic. Rajewsky and colleagues show that NF-κB activation driven by the kinase IKK is…”
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RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100 by Derudder, Emmanuel, Dejardin, Emmanuel, Pritchard, Linda L, Green, Douglas R, Korner, Marie, Baud, Veronique

“…Tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-beta receptor (LTbetaR) signaling both play important roles in inflammatory and immune responses…”
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T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia1 by Fogli, Laura K., Sundrud, Mark S., Goel, Swati, Bajwa, Sofia, Jensen, Kari, Derudder, Emmanuel, Sun, Amy, Coffre, Maryaline, Uyttenhove, Catherine, van Snick, Jacques, Schmidt-Supprian, Marc, Rao, Anjana, Grunig, Gabriele, Durbin, Joan, Casola, Stefano S., Rajewsky, Klaus, Koralov, Sergei B.

“…Th17 cells are a proinflammatory subset of effector T cells that have been implicated in the pathogenesis of asthma. Their production of the cytokine IL-17 is…”
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Correction: T cell–derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia by Fogli, Laura K., Sundrud, Mark S., Goel, Swati, Bajwa, Sofia, Jensen, Kari, Derudder, Emmanuel, Sun, Amy, Coffre, Maryaline, Uyttenhove, Catherine, Van Snick, Jacques, Schmidt-Supprian, Marc, Rao, Anjana, Grunig, Gabriele, Durbin, Joan, Casola, Stefano S., Rajewsky, Klaus, Koralov, Sergei B.

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Role of NFkappaB signaling in normal and malignant B cell development by Sasaki, Yoshiteru, Schmidt-Supprian, Marc, Derudder, Emmanuel, Rajewsky, Klaus

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