Search Results - "Derrick, Steven C"

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk by Mayer-Barber, Katrin D., Andrade, Bruno B., Oland, Sandra D., Amaral, Eduardo P., Barber, Daniel L., Gonzales, Jacqueline, Derrick, Steven C., Shi, Ruiru, Kumar, Nathella Pavan, Wei, Wang, Yuan, Xing, Zhang, Guolong, Cai, Ying, Babu, Subash, Catalfamo, Marta, Salazar, Andres M., Via, Laura E., Barry III, Clifton E., Sher, Alan

“…Active tuberculosis has been linked to excessive type I interferon induction whereas interleukin-1 may have protective effects; here it is shown that…”
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ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression by Derrick, Steven C, Morris, Sheldon L

“…The secreted Mycobacterium tuberculosis protein, ESAT6, has been studied extensively in pathogenicity and vaccine experiments. Despite these studies little is…”
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Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B by Parra, Marcela, Weitner, Megan, Yang, Amy, Akue, Adovi, Liu, Xia, Schmidt, Thomas, Allman, Windy R., Akkoyunlu, Mustafa, Derrick, Steven C.

“…To better understand anti-malaria protective immune responses, we examined the cellular mechanisms that govern protective immunity in a murine Plasmodium…”
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Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis by Hinchey, Joseph, Lee, Sunhee, Jeon, Bo Y, Basaraba, Randall J, Venkataswamy, Manjunatha M, Chen, Bing, Chan, John, Braunstein, Miriam, Orme, Ian M, Derrick, Steven C, Morris, Sheldon L, Jacobs, Jr, William R, Porcelli, Steven A

“…The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the…”
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Molecular analysis of non-specific protection against murine malaria induced by BCG vaccination by Parra, Marcela, Liu, Xia, Derrick, Steven C, Yang, Amy, Tian, Jinhua, Kolibab, Kristopher, Kumar, Sanjai, Morris, Sheldon L

“…Although the effectiveness of BCG vaccination in preventing adult pulmonary tuberculosis (TB) has been highly variable, epidemiologic studies have suggested…”
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The Primary Mechanism of Attenuation of Bacillus Calmette-Guérin Is a Loss of Secreted Lytic Function Required for Invasion of Lung Interstitial Tissue by Hsu, Tsungda, Hingley-Wilson, Suzanne M., Chen, Bing, Chen, Mei, Dai, Annie Z., Morin, Paul M., Marks, Carolyn B., Padiyar, Jeevan, Goulding, Celia, Gingery, Mari, Eisenberg, David, Russell, Robert G., Derrick, Steven C., Collins, Frank M., Morris, Sheldon L., King, C. Harold, Jacobs, William R.

“…Tuberculosis remains a leading cause of death worldwide, despite the availability of effective chemotherapy and a vaccine. Bacillus Calmette-Guérin (BCG), the…”
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Mycobacterium bovis BCG Immunization Induces Protective Immunity against Nine Different Mycobacterium tuberculosis Strains in Mice by BO YOUNG JEON, DERRICK, Steven C, LIM, Jaehyun, KOLIBAB, Kristopher, DHEENADHAYALAN, Veerabadran, AMY LI YANG, KREISWIRTH, Barry, MORRIS, Sheldon L

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Enhanced efficacy of BCG vaccine formulated in adjuvant is dependent on IL-17A expression by Derrick, Steven C., Yang, Amy, Cowley, Siobhan

“…A new, more effective vaccine against tuberculosis (TB) is urgently needed to curtail the current TB problem. The only licensed vaccine, BCG, has been shown to…”
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Formulation of a mmaA4 gene deletion mutant of Mycobacterium bovis BCG in cationic liposomes significantly enhances protection against tuberculosis by Derrick, Steven C, Dao, Dee, Yang, Amy, Kolibab, Kris, Jacobs, William R, Morris, Sheldon L

“…A new vaccination strategy is urgently needed for improved control of the global tuberculosis (TB) epidemic. Using a mouse aerosol Mycobacterium tuberculosis…”
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Co-expression of Interleukin-15 Enhances the Protective Immune Responses Induced by Immunization with a Murine Malaria MVA-Based Vaccine Encoding the Circumsporozoite Protein by Parra, Marcela, Liu, Xia, Derrick, Steven C, Yang, Amy, Molina-Cruz, Alvaro, Barillas-Mury, Carolina, Zheng, Hong, Thao Pham, Phuong, Sedegah, Martha, Belmonte, Arnel, Litilit, Dianne D, Waldmann, Thomas A, Kumar, Sanjai, Morris, Sheldon L, Perera, Liyanage P

“…Malaria remains a major global public health problem with an estimated 200 million cases detected in 2012. Although the most advanced candidate malaria vaccine…”
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Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis by Sambandamurthy, Vasan K, Derrick, Steven C, Jalapathy, Kripa V, Chen, Bing, Russell, Robert G, Morris, Sheldon L, Jacobs, William R

“…We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The [Delta]lysA [Delta]panCD…”
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Highly Persistent and Effective Prime/Boost Regimens against Tuberculosis That Use a Multivalent Modified Vaccine Virus Ankara-Based Tuberculosis Vaccine with Interleukin-15 as a Molecular Adjuvant by Kolibab, Kristopher, Yang, Amy, Derrick, Steven C, Waldmann, Thomas A, Perera, Liyanage P, Morris, Sheldon L

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Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice by Parra, Marcela, Derrick, Steven C, Yang, Amy, Tian, Jinhua, Kolibab, Kristopher, Oakley, Miranda, Perera, Liyanage P, Jacobs, William R, Kumar, Sanjai, Morris, Sheldon L

“…Given the considerable geographic overlap in the endemic regions for malaria and tuberculosis, it is probable that co-infections with Mycobacterium…”
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Trained Immunity and Susceptibility to HIV by Derrick, Steven C

“…In this issue of Clinical and Vaccine Immunology, K. Jensen et al. (Clin Vaccine Immunol 24:e00360-16, 2017, https://doi.org/10.1128/CVI.00360-16) describe a…”
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Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells by Derrick, Steven C, Yabe, Idalia M, Yang, Amy, Morris, Sheldon L

“…Abstract The development of improved vaccines against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of…”
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Immunization with a DNA Vaccine Cocktail Protects Mice Lacking CD4 Cells against an Aerogenic Infection with Mycobacterium tuberculosis by DERRICK, Steven C, REPIQUE, Charlene, SNOY, Philip, LI YANG, Amy, MORRIS, Sheldon

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Intranasal administration of Mycobacterium bovis BCG induces superior protection against aerosol infection with Mycobacterium tuberculosis in mice by Derrick, Steven C, Kolibab, Kristopher, Yang, Amy, Morris, Sheldon L

“…Despite the widespread use of Mycobacterium bovis BCG, the only licensed vaccine against tuberculosis (TB), TB remains a global epidemic. To assess whether…”
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Early Pulmonary Cytokine and Chemokine Responses in Mice Immunized with Three Different Vaccines against Mycobacterium tuberculosis Determined by PCR Array by Lim, JaeHyun, Derrick, Steven C, Kolibab, Kristopher, Yang, Amy Li, Porcelli, Steven, Jacobs, William R, Morris, Sheldon L

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Vaccination with a Sindbis Virus-Based DNA Vaccine Expressing Antigen 85B Induces Protective Immunity against Mycobacterium tuberculosis by Derrick, Steven C, Yang, Amy Li, Morris, Sheldon L

“…To improve DNA vaccination against Mycobacterium tuberculosis, we evaluated the effectiveness of a Sindbis virus-based DNA construct expressing the…”
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Induction of Unconventional T Cells by a Mutant Mycobacterium bovis BCG Strain Formulated in Cationic Liposomes Correlates with Protection against Mycobacterium tuberculosis Infections of Immunocompromised Mice by Derrick, Steven C, Yabe, Idalia, Morris, Sheldon, Cowley, Siobhan

“…Earlier studies aimed at defining protective immunity induced by Mycobacterium bovis BCG immunization have largely focused on the induction of antituberculosis…”
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