Search Results - "Dermody, Terence S"

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies by Silva, Laurie A, Dermody, Terence S

“…Chikungunya virus (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal inflammatory disease in humans characterized by fever, polyarthralgia,…”
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Microbial Vertical Transmission during Human Pregnancy by Arora, Nitin, Sadovsky, Yoel, Dermody, Terence S., Coyne, Carolyn B.

“…Congenital infections with pathogens such as Zika virus, Toxoplasma gondii, Listeria monocytogenes, Treponema pallidium, parvovirus, HIV, varicella zoster…”
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The sweet spot: defining virus–sialic acid interactions by Stencel-Baerenwald, Jennifer E., Reiss, Kerstin, Reiter, Dirk M., Stehle, Thilo, Dermody, Terence S.

“…Key Points Many viruses engage sialylated glycans to bind to and infect cells. Sialic acid-binding viruses include influenza virus, reovirus, adenovirus and…”
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Rescuing the physician-scientist workforce: the time for action is now by Milewicz, Dianna M, Lorenz, Robin G, Dermody, Terence S, Brass, Lawrence F

“…The 2014 NIH Physician-Scientist Workforce (PSW) Working Group report identified distressing trends among the small proportion of physicians who consider…”
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Intestinal Microbiota Promote Enteric Virus Replication and Systemic Pathogenesis by Kuss, Sharon K., Best, Gavin T., Etheredge, Chris A., Pruijssers, Andrea J., Frierson, Johnna M., Hooper, Lora V., Dermody, Terence S., Pfeiffer, Julie K.

“…Intestinal bacteria aid host health and limit bacterial pathogen colonization. However, the influence of bacteria on enteric viruses is largely unknown. We…”
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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 by Kato, Hiroki, Takeuchi, Osamu, Mikamo-Satoh, Eriko, Hirai, Reiko, Kawai, Tomoji, Matsushita, Kazufumi, Hiiragi, Akane, Dermody, Terence S, Fujita, Takashi, Akira, Shizuo

“…The ribonucleic acid (RNA) helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) recognize distinct viral and…”
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A viral trigger for celiac disease by Brown, Judy J, Jabri, Bana, Dermody, Terence S

“…Viruses and CD Although 30–45% of the United States population has the CD risk alleles (HLA haplotypes DQ2 and DQ8), only 1% of the population develops the…”
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Glycan-mediated enhancement of reovirus receptor binding by Koehler, Melanie, Aravamudhan, Pavithra, Guzman-Cardozo, Camila, Dumitru, Andra C., Yang, Jinsung, Gargiulo, Serena, Soumillion, Patrice, Dermody, Terence S., Alsteens, David

“…Viral infection is an intricate process that requires the concerted action of both viral and host cell components. Entry of viruses into cells is initiated by…”
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Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18 by Zhang, Benyue, Chassaing, Benoit, Shi, Zhenda, Uchiyama, Robin, Zhang, Zhan, Denning, Timothy L., Crawford, Sue E., Pruijssers, Andrea J., Iskarpatyoti, Jason A., Estes, Mary K., Dermody, Terence S., Ouyang, Wenjun, Williams, Ifor R., Vijay-Kumar, Matam, Gewirtz, Andrew T.

“…Activators of innate immunity may have the potential to combat a broad range of infectious agents. We report that treatment with bacterial flagellin prevented…”
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Transport to Late Endosomes Is Required for Efficient Reovirus Infection by MAINOU, Bernardo A, DERMODYA, Terence S

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A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization by Silva, Laurie A, Khomandiak, Solomiia, Ashbrook, Alison W, Weller, Romy, Heise, Mark T, Morrison, Thomas E, Dermody, Terence S

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Contemporary enterovirus-D68 isolates infect human spinal cord organoids by Aguglia, Gabrielle, Coyne, Carolyn B, Dermody, Terence S, Williams, John V, Freeman, Megan Culler

“…Enterovirus D68 (EV-D68) is a nonpolio enterovirus associated with severe respiratory illness and acute flaccid myelitis (AFM), a polio-like illness causing…”
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Structure of orthoreovirus RNA chaperone σNS, a component of viral replication factories by Zhao, Boyang, Hu, Liya, Kaundal, Soni, Neetu, Neetu, Lee, Christopher H., Somoulay, Xayathed, Sankaran, Banumathi, Taylor, Gwen M., Dermody, Terence S., Venkataram Prasad, B. V.

“…The mammalian orthoreovirus (reovirus) σNS protein is required for formation of replication compartments that support viral genome replication and capsid…”
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Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons by Aravamudhan, Pavithra, Raghunathan, Krishnan, Konopka-Anstadt, Jennifer, Pathak, Amrita, Sutherland, Danica M, Carter, Bruce D, Dermody, Terence S

“…Several barriers protect the central nervous system (CNS) from pathogen invasion. Yet viral infections of the CNS are common and often debilitating…”
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Reovirus directly engages integrin to recruit clathrin for entry into host cells by Koehler, Melanie, Petitjean, Simon J. L., Yang, Jinsung, Aravamudhan, Pavithra, Somoulay, Xayathed, Lo Giudice, Cristina, Poncin, Mégane A., Dumitru, Andra C., Dermody, Terence S., Alsteens, David

“…Reovirus infection requires the concerted action of viral and host factors to promote cell entry. After interaction of reovirus attachment protein σ1 with…”
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Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network by Knowlton, Jonathan J., Gestaut, Daniel, Ma, Boxue, Taylor, Gwen, Seven, Alpay Burak, Leitner, Alexander, Wilson, Gregory J., Shanker, Sreejesh, Yates, Nathan A., Prasad, B. V. Venkataram, Aebersold, Ruedi, Chiu, Wah, Frydman, Judith, Dermody, Terence S.

“…Intracellular protein homeostasis is maintained by a network of chaperones that function to fold proteins into their native conformation. The eukaryotic TRiC…”
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The Early Interferon Response to Rotavirus Is Regulated by PKR and Depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3 by SEN, Adrish, PRUIJSSERS, Andrea J, DERMODY, Terence S, GARCIA-SASTRE, Adolfo, GREENBERG, Harry B

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Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice by Ashbrook, Alison W, Burrack, Kristina S, Silva, Laurie A, Montgomery, Stephanie A, Heise, Mark T, Morrison, Thomas E, Dermody, Terence S

“…Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has reemerged to cause profound epidemics of fever, rash, and arthralgia throughout sub-Saharan…”
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The GM2 glycan serves as a functional coreceptor for serotype 1 reovirus by Reiss, Kerstin, Stencel, Jennifer E, Liu, Yan, Blaum, Bärbel S, Reiter, Dirk M, Feizi, Ten, Dermody, Terence S, Stehle, Thilo

“…Viral attachment to target cells is the first step in infection and also serves as a determinant of tropism. Like many viruses, mammalian reoviruses bind with…”
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Efficient norovirus and reovirus replication in the mouse intestine requires microfold (M) cells by Gonzalez-Hernandez, Mariam B, Liu, Thomas, Payne, Hilary C, Stencel-Baerenwald, Jennifer E, Ikizler, Mine, Yagita, Hideo, Dermody, Terence S, Williams, Ifor R, Wobus, Christiane E

“…Microfold (M) cells are specialized intestinal epithelial cells that internalize particulate antigens and aid in the establishment of immune responses to…”
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