Search Results - "Derksen, Merel"

A novel experimental approach for the selective isolation and characterization of human RNase MRP by Derksen, Merel, Mertens, Vicky, Visser, Eline A., Arts, Janine, Vree Egberts, Wilma, Pruijn, Ger J. M.

“…RNase MRP is a ribonucleoprotein complex involved in the endoribonucleolytic cleavage of different RNAs. Mutations in the RNA component of the RNP are the…”
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A Novel Method to Isolate RNase MRP Using RNA Streptavidin Aptamer Tags by Charteau, Violette, Derksen, Merel, Pruijn, Ger J M

“…Interactions between RNA-binding proteins and RNA molecules are at the center of multiple biological processes. Therefore, accurate characterization of the…”
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RNase P-Mediated Sequence-Specific Cleavage of RNA by Engineered External Guide Sequences by Derksen, Merel, Mertens, Vicky, Pruijn, Ger J M

“…The RNA cleavage activity of RNase P can be employed to decrease the levels of specific RNAs and to study their function or even to eradicate pathogens. Two…”
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LINE-1 Hypermethylation in Serum Cell-Free DNA of Relapsing Remitting Multiple Sclerosis Patients by Dunaeva, Marina, Derksen, Merel, Pruijn, Ger J. M.

“…Concentrations of cell-free DNA (cfDNA) circulating in blood and its epigenetic variation, such as DNA methylation, may provide useful diagnostic or prognostic…”
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Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier by Jelinsky, Scott A, Derksen, Merel, Bauman, Eric, Verissimo, Carla S, van Dooremalen, Wies T M, Roos, Jamie Lee, Higuera Barón, Celia, Caballero-Franco, Celia, Johnson, Bryce G, Rooks, Michelle G, Pott, Johanna, Oldenburg, Bas, Vries, Robert G J, Boj, Sylvia F, Kasaian, Marion T, Pourfarzad, Farzin, Rosadini, Charles V

“…Abstract Background Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by…”
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Abstract 241: Patient-derived organoids as a reliable screening platform for assessing ADC efficacy and specificity by Mori, Daniele, Adegbenro, Vineeta, Morales, Francisco, Overmeer, René, Lukovac, Sabina, Boj, Sylvia, Derksen, Merel

“…Abstract Antibody-drug conjugates (ADCs) are a new class of pharmaceutical drugs designed to deliver cytotoxic agents to cells expressing specific antigens…”
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Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules by Kourula, Stephanie, Derksen, Merel, Jardi, Ferran, Jonkers, Sophie, van Heerden, Marjolein, Verboven, Peter, Theuns, Veronique, Van Asten, Stijn, Huybrechts, Tinne, Kunze, Annett, Frazer-Mendelewska, Ewa, Lai, Ka Wai, Overmeer, René, Roos, Jamie Lee, Vries, Robert G.J., Boj, Sylvia F., Monshouwer, Mario, Pourfarzad, Farzin, Snoeys, Jan

“…•Human intestinal organoids can be utilized for drug ADME and safety profiling.•Main drug metabolizing enzymes are active in duodenal and colonic…”
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Abstract 189: Developing a patient-derived organoid biobank, suitable for large scale drug screenings by Fielmich, Lars-Eric, Buijs, Annemarie, Mori, Daniele, Viergever, Bas, Draoui, Nihed, Schepers, Anna, Costa e Silva, Mariana M., Scholtus, Mathijs, Mahmoudi, Tokameh, Zuiverloon, Tahlita, Derksen, Merel, Gavine, Paul, Boj, Sylvia F., Meijer, Richard, Kranenburg, Onno, Arts, Janine, Vries, Robert

“…Abstract Conventional models for preclinical drug screening offer poor predictive value for patient response, causing high attrition rates of new agents in the…”
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Multiplex peptide-based B cell epitope mapping by Hensen, Sanne M M, Derksen, Merel, Pruijn, Ger J M

“…B cell epitope mapping is widely applied to determine antibody-binding sites. Several methods exist to map B cell epitopes and here we describe three methods…”
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