Search Results - "Derks, J.L."

Single organ metastatic disease and local disease status, prognostic factors for overall survival in stage IV non-small cell lung cancer: Results from a population-based study by Hendriks, L.E, Derks, J.L, Postmus, P.E, Damhuis, R.A, Houben, R.M.A, Troost, E.G.C, Hochstenbag, M.M, Smit, E.F, Dingemans, A.-M.C

“…Highlights • OS significantly longer in single organ metastatic disease compared to 2 or ⩾3 organs. • Single organ metastases also prognostic in subgroup of18…”
Get full text

Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC) by Hermans, B.C.M., Derks, J.L., Thunnissen, E., van Suylen, R.J., den Bakker, M.A., Groen, H.J.M., Smit, E.F., Damhuis, R.A., van den Broek, E.C., Stallinga, C.M., Roemen, G.M., Speel, E.J.M., Dingemans, A.-M.C.

“…•PD-L1 ≥ 1% is expressed in 16% of stage IV LCNEC, 5% has expression ≥50%.•PD-L1 staining in LCNEC is comparable to values in SCLC, but lower than in NSCLC.•No…”
Get full text

Radiological follow-up in patients with resected pulmonary carcinoids: Should we reduce radiation exposure? by Heijboer, F.W.J., Mulders, T.A., van Straten, M., Moonen, L., Speel, E.J.M., von der Thüsen, J.H., Derks, J.L., Dingemans, A.C.

“…•Resected TC patients at 30y or younger had an additional lifetime cancer risk up to 3.1 % (ENETS) at 40y.•Less extensive radiological follow-up for young TC…”
Get full text

Association of molecular status and metastatic organs at diagnosis in patients with stage IV non-squamous non-small cell lung cancer by Kuijpers, C.C.H.J., Hendriks, L.E.L., Derks, J.L., Dingemans, A-M.C., van Lindert, A.S.R., van den Heuvel, M.M., Damhuis, R.A., Willems, S.M.

“…•NSCLC molecular status was associated with metastatic pattern at diagnosis.•EGFR+ tumors more often bone and pleural metastases than triple-negative.•EGFR+…”
Get full text

Pulmonary neuroendocrine neoplasms with well differentiated morphology and high proliferative activity: illustrated by a case series and review of the literature by Hermans, B.C.M., Derks, J.L., Moonen, L., Habraken, C.H.J., der Thüsen, J. von, Hillen, L.M., Speel, E.J.M., Dingemans, A-M.C.

“…•Carcinoids are characterized by well differentiated morphology and low proliferation.•LCNEC is characterized by poorly differentiated morphology and high…”
Get full text

DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile by Hermans, B.C.M., Derks, J.L., Thunnissen, E., van Suylen, R.J., den Bakker, M.A., Groen, H.J.M., Smit, E.F., Damhuis, R.A., van den Broek, E.C., Ruland, A., Speel, E.J.M., Dingemans, A.M.C.

“…•DLL3 is expressed in 74% of stage IV LCNEC patients•The majority (80%) has cytoplasmic/membranous expression•DLL3 is expressed in both SCLC- and NSCLC-like…”
Get full text

Exploring imaging features of molecular subtypes of large cell neuroendocrine carcinoma (LCNEC) by Hermans, B.C.M., Sanduleanu, S., Derks, J.L., Woodruff, H., Hillen, L.M., Casale, R., Hoesein, F. Mohamed, de Jong, E., Berge, D.M.H.J. ten, Speel, E.J.M., Lambin, P., Gietema, H.A., Dingemans, A-M.C.

“…•LCNEC has radiological characteristics of both SCLC and NSCLC.•LCNEC can be classified in molecular SCLC-like and NSCLC-like subtypes.•Molecular LCNEC…”
Get full text

Single Organ Metastatic Disease, a New Prognostic Factor for Overall Survival (OS) in Stage IV Non-Small Cell Lung Cancer (NSCLC) by Hendriks, L., Derks, J.L., Postmus, P.E., Damhuis, R.A., Houben, R.M., Troost, E.G., Hochstenbag, M.M., Smit, E.F., Dingemans, A.-M.C.

Get full text

Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC) by Hermans, B.C.M., Derks, J.L., Thunissen, E., van Suylen, R.J., den Bakker, M.A., Groen, H.J.M., Smit, E.F., Damhuis, R.A., van den Broek, E.C., PALGA-group, P., Stallinga, C.M., Roemen, G.M., Speel, E.J., Dingemans, A.-M.C.

Get full text

A population based analysis of outcome of chemotherapy for metastatic pulmonary large cell neuroendocrine carcinomas: does the regimen matter? by Derks, J.L., van Suylen, R.J., Thunnissen, E., Den Bakker, M.A., Groen, H., Smit, E.F., Damhuis, R.A., Speel, E.-J., Dingemans, A.-M.C.

Get full text