Search Results - "Derek H. R. Barton"

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    Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosis by Rozwarski, Denise A., Grant, Gregory A., Derek H. R. Barton, Jacobs, William R., Sacchettini, James C.

    “…The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an enzyme essential for mycolic acid…”
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    Journal Article
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    Total synthesis of uracil analogs of sinefungin by Barton, Derek H. R, Gero, Stephane D, Lawrence, Francoise, Robert-Gero, Malka, Quiclet-Sire, Beatrice, Samadi, Mohammad

    Published in Journal of medicinal chemistry (01-01-1992)
    “…Analogues of sinefungin derivatives 18a and 18b have been prepared from uridine and L-aspartic acid. The key step in the synthesis was the coupling of the…”
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    Journal Article
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